Detalhe da pesquisa
1.
Development of selective inhibitors of phosphatidylinositol 3-kinase C2α.
Nat Chem Biol
; 19(1): 18-27, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36109648
2.
Small Molecules Targeting Human UDP-GlcNAc 2-Epimerase.
Chembiochem
; 24(24): e202300555, 2023 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37769151
3.
Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1.
PLoS Biol
; 15(6): e2000784, 2017 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-28570591
4.
Revealing cytotoxic substructures in molecules using deep learning.
J Comput Aided Mol Des
; 34(7): 731-746, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32297073
5.
Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin lymphoma.
Blood
; 129(1): 71-81, 2017 01 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27733358
6.
Small Molecules Targeting Human N-Acetylmannosamine Kinase.
Chembiochem
; 18(13): 1279-1285, 2017 07 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28346741
7.
A Chemical Disruptor of the ClpX Chaperone Complex Attenuates the Virulence of Multidrug-Resistant Staphylococcus aureus.
Angew Chem Int Ed Engl
; 56(49): 15746-15750, 2017 12 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28906057
8.
Tractable synthesis of multipurpose screening compounds with under-represented molecular features for an open access screening platform.
Mol Divers
; 18(3): 483-95, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24687389
9.
Small-molecule screening identifies modulators of aquaporin-2 trafficking.
J Am Soc Nephrol
; 24(5): 744-58, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23559583
10.
[Online addictive disease]. / Onlinesucht - Realität auch ohne offizielle Diagnose.
Ther Umsch
; 71(10): 599-607, 2014 Oct.
Artigo
em Alemão
| MEDLINE | ID: mdl-25257114
11.
Identification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A.
Biochem Biophys Res Commun
; 439(2): 228-34, 2013 Sep 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-23981806
12.
The FGFR inhibitor PD173074 binds to the C-terminus of oncofetal HMGA2 and modulates its DNA-binding and transcriptional activation functions.
FEBS Lett
; 597(15): 1977-1988, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37259564
13.
CLK2 and CLK4 are regulators of DNA damage-induced NF-κB targeted by novel small molecule inhibitors.
Cell Chem Biol
; 30(10): 1303-1312.e3, 2023 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37506701
14.
An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor.
Elife
; 122023 10 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37843983
15.
Small molecule inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation.
PLoS One
; 18(2): e0278325, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36745631
16.
Structural Basis for Highly Selective Class II Alpha Phosphoinositide-3-Kinase Inhibition.
J Med Chem
; 66(20): 14278-14302, 2023 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37819647
17.
Sustainable synthesis and automated deposition: an accessible discovery screening library of fragment-like purines.
Mol Divers
; 16(3): 541-51, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22890959
18.
Disruptors of AKAP-Dependent Protein-Protein Interactions.
Methods Mol Biol
; 2483: 117-139, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35286673
19.
Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.
J Med Chem
; 65(16): 11126-11149, 2022 08 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35921615
20.
Glycolytic flux control by drugging phosphoglycolate phosphatase.
Nat Commun
; 13(1): 6845, 2022 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36369173