Detalhe da pesquisa
1.
Identification and in vitro characterization of a new series of potent and highly selective G9a inhibitors as novel anti-fibroadipogenic agents.
Bioorg Med Chem Lett
; 72: 128858, 2022 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35718104
2.
Discovery of a Novel Series of Potent SHP2 Allosteric Inhibitors.
ACS Med Chem Lett
; 14(5): 645-651, 2023 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37197453
3.
Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors.
ACS Med Chem Lett
; 14(2): 156-162, 2023 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36793438
4.
[11C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins.
J Med Chem
; 64(16): 12003-12021, 2021 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34351166
5.
5,6-Dihydroxypyrimidine Scaffold to Target HIV-1 Nucleocapsid Protein.
ACS Med Chem Lett
; 11(5): 766-772, 2020 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32435383
6.
Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand.
J Med Chem
; 63(15): 8608-8633, 2020 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32662649
7.
Use of 'dilute-and-shoot' liquid chromatography-high resolution mass spectrometry in preclinical research: application to a DMPK study of perhexiline in mouse plasma.
J Pharm Biomed Anal
; 118: 70-80, 2016 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-26517851
8.
Discovery and Characterization of Novel Anti-schistosomal Properties of the Anti-anginal Drug, Perhexiline and Its Impact on Schistosoma mansoni Male and Female Reproductive Systems.
PLoS Negl Trop Dis
; 10(8): e0004928, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27518281
9.
Structure-activity relationship and properties optimization of a series of quinazoline-2,4-diones as inhibitors of the canonical Wnt pathway.
Eur J Med Chem
; 95: 526-45, 2015 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25847770
10.
Brain penetration assessment in vivo: a reliable and simple method in anesthetized rats at steady state.
J Neurosci Methods
; 232: 199-206, 2014 Jul 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-24880048