Pesquisa | BVS Integralidade em Saúde

1.

The Wnt Pathway: From Signaling Mechanisms to Synthetic Modulators.

Rim, Ellen Youngsoo; Clevers, Hans; Nusse, Roel.

Annu Rev Biochem ; 91: 571-598, 2022 06 21.

Artigo em Inglês | MEDLINE | ID: mdl-35303793

2.

Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture.

Peng, Weng Chuan; Logan, Catriona Y; Fish, Matt; Anbarchian, Teni; Aguisanda, Francis; Álvarez-Varela, Adrián; Wu, Peng; Jin, Yinhua; Zhu, Junjie; Li, Bin; Grompe, Markus; Wang, Bruce; Nusse, Roel.

Cell ; 175(6): 1607-1619.e15, 2018 11 29.

Artigo em Inglês | MEDLINE | ID: mdl-30500539

3.

Wnt/ß-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.

Nusse, Roel; Clevers, Hans.

Cell ; 169(6): 985-999, 2017 Jun 01.

Artigo em Inglês | MEDLINE | ID: mdl-28575679

4.

Wnt/ß-catenin signaling and disease.

Clevers, Hans; Nusse, Roel.

Cell ; 149(6): 1192-205, 2012 Jun 08.

Artigo em Inglês | MEDLINE | ID: mdl-22682243

5.

The Lasker-Koshland Special Achievement Award in Medical Science awarded to Piet Borst.

Nusse, Roel; Shapiro, Lucy.

Proc Natl Acad Sci U S A ; 120(39): e2311130120, 2023 09 26.

Artigo em Inglês | MEDLINE | ID: mdl-37732755

6.

Wnt signaling regulates hepatocyte cell division by a transcriptional repressor cascade.

Jin, Yinhua; Anbarchian, Teni; Wu, Peng; Sarkar, Abby; Fish, Matt; Peng, Weng Chuan; Nusse, Roel.

Proc Natl Acad Sci U S A ; 119(30): e2203849119, 2022 07 26.

Artigo em Inglês | MEDLINE | ID: mdl-35867815

7.

Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling.

Chen, Wei-Shen; Antic, Dragana; Matis, Maja; Logan, Catriona Y; Povelones, Michael; Anderson, Graham A; Nusse, Roel; Axelrod, Jeffrey D.

Cell ; 133(6): 1093-105, 2008 Jun 13.

Artigo em Inglês | MEDLINE | ID: mdl-18555784

8.

Wnt signalling: conquering complexity.

Wiese, Katrin E; Nusse, Roel; van Amerongen, Renée.

Development ; 145(12)2018 06 26.

Artigo em Inglês | MEDLINE | ID: mdl-29945986

9.

Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver.

Wang, Bruce; Zhao, Ludan; Fish, Matt; Logan, Catriona Y; Nusse, Roel.

Nature ; 524(7564): 180-5, 2015 Aug 13.

Artigo em Inglês | MEDLINE | ID: mdl-26245375

10.

Tissue Repair in the Mouse Liver Following Acute Carbon Tetrachloride Depends on Injury-Induced Wnt/ß-Catenin Signaling.

Zhao, Ludan; Jin, Yinhua; Donahue, Katie; Tsui, Margaret; Fish, Matt; Logan, Catriona Y; Wang, Bruce; Nusse, Roel.

Hepatology ; 69(6): 2623-2635, 2019 06.

Artigo em Inglês | MEDLINE | ID: mdl-30762896

11.

Gene expression profiling of low-grade endometrial stromal sarcoma indicates fusion protein-mediated activation of the Wnt signaling pathway.

Przybyl, Joanna; Kidzinski, Lukasz; Hastie, Trevor; Debiec-Rychter, Maria; Nusse, Roel; van de Rijn, Matt.

Gynecol Oncol ; 149(2): 388-393, 2018 05.

Artigo em Inglês | MEDLINE | ID: mdl-29544705

12.

Single-Molecule Imaging of Wnt3A Protein Diffusion on Living Cell Membranes.

Lippert, Anna; Janeczek, Agnieszka A; Fürstenberg, Alexandre; Ponjavic, Aleks; Moerner, W E; Nusse, Roel; Helms, Jill A; Evans, Nicholas D; Lee, Steven F.

Biophys J ; 113(12): 2762-2767, 2017 Dec 19.

Artigo em Inglês | MEDLINE | ID: mdl-29262368

13.

Three decades of Wnts: a personal perspective on how a scientific field developed.

Nusse, Roel; Varmus, Harold.

EMBO J ; 31(12): 2670-84, 2012 Jun 13.

Artigo em Inglês | MEDLINE | ID: mdl-22617420

14.

Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells.

Jan, Taha Adnan; Chai, Renjie; Sayyid, Zahra Nabi; van Amerongen, Renée; Xia, Anping; Wang, Tian; Sinkkonen, Saku Tapani; Zeng, Yi Arial; Levin, Jared Ruben; Heller, Stefan; Nusse, Roel; Cheng, Alan Gi-Lun.

Development ; 140(6): 1196-206, 2013 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-23444352

15.

Wnt/ß-Catenin-Responsive Cells in Prostatic Development and Regeneration.

Lee, Suk Hyung; Johnson, Daniel T; Luong, Richard; Yu, Eun Jeong; Cunha, Gerald R; Nusse, Roel; Sun, Zijie.

Stem Cells ; 33(11): 3356-67, 2015 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-26220362

16.

Cell signalling: Disarming Wnt.

Nusse, Roel.

Nature ; 519(7542): 163-4, 2015 Mar 12.

Artigo em Inglês | MEDLINE | ID: mdl-25731170

17.

Telomerase modulates Wnt signalling by association with target gene chromatin.

Park, Jae-Il; Venteicher, Andrew S; Hong, Ji Yeon; Choi, Jinkuk; Jun, Sohee; Shkreli, Marina; Chang, Woody; Meng, Zhaojing; Cheung, Peggie; Ji, Hong; McLaughlin, Margaret; Veenstra, Timothy D; Nusse, Roel; McCrea, Pierre D; Artandi, Steven E.

Nature ; 460(7251): 66-72, 2009 Jul 02.

Artigo em Inglês | MEDLINE | ID: mdl-19571879

18.

Wnt5a can both activate and repress Wnt/ß-catenin signaling during mouse embryonic development.

van Amerongen, Renée; Fuerer, Christophe; Mizutani, Makiko; Nusse, Roel.

Dev Biol ; 369(1): 101-14, 2012 Sep 01.

Artigo em Inglês | MEDLINE | ID: mdl-22771246

19.

ROR2 is a novel prognostic biomarker and a potential therapeutic target in leiomyosarcoma and gastrointestinal stromal tumour.

Edris, Badreddin; Espinosa, Iñigo; Mühlenberg, Thomas; Mikels, Amanda; Lee, Cheng-Han; Steigen, Sonja E; Zhu, Shirley; Montgomery, Kelli D; Lazar, Alexander J F; Lev, Dina; Fletcher, Jonathan A; Beck, Andrew H; West, Robert B; Nusse, Roel; van de Rijn, Matt.

J Pathol ; 227(2): 223-33, 2012 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-22294416

20.

Intermittent fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver.

Sarkar, Abby; Jin, Yinhua; DeFelice, Brian C; Logan, Catriona Y; Yang, Yan; Anbarchian, Teni; Wu, Peng; Morri, Maurizio; Neff, Norma F; Nguyen, Huy; Rulifson, Eric; Fish, Matthew; Kaye, Avi Gurion; Martínez Jaimes, Azalia M; Nusse, Roel.

Elife ; 122023 01 31.

Artigo em Inglês | MEDLINE | ID: mdl-36719070

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