Detalhe da pesquisa
1.
The role of claudin-2 in kidney function and dysfunction.
Biochem Soc Trans
; 51(4): 1437-1445, 2023 08 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37387353
2.
Trans-myocardial Extraction of Endothelin-1 Correlates with Increased Microcirculatory Resistance following Percutaneous Coronary Intervention.
J Interv Cardiol
; 2022: 9154048, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36262459
3.
Apelin is expressed throughout the human kidney, is elevated in chronic kidney disease & associates independently with decline in kidney function.
Br J Clin Pharmacol
; 88(12): 5295-5306, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35748053
4.
International Union of Basic and Clinical Pharmacology. CVII. Structure and Pharmacology of the Apelin Receptor with a Recommendation that Elabela/Toddler Is a Second Endogenous Peptide Ligand.
Pharmacol Rev
; 71(4): 467-502, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31492821
5.
The biased apelin receptor agonist, MM07, reverses Sugen/hypoxia-induced pulmonary arterial hypertension as effectively as the endothelin antagonist macitentan.
Front Pharmacol
; 15: 1369489, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38655187
6.
The therapeutic potential of apelin in kidney disease.
Nat Rev Nephrol
; 17(12): 840-853, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34389827
7.
In vitro metabolism of synthetic Elabela/Toddler (ELA-32) peptide in human plasma and kidney homogenates analyzed with mass spectrometry and validation of endogenous peptide quantification in tissues by ELISA.
Peptides
; 145: 170642, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34455010
8.
Differential expression in humans of the viral entry receptor ACE2 compared with the short deltaACE2 isoform lacking SARS-CoV-2 binding sites.
Sci Rep
; 11(1): 24336, 2021 12 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34934117
9.
Plasma levels of apelin are reduced in patients with liver fibrosis and cirrhosis but are not correlated with circulating levels of bone morphogenetic protein 9 and 10.
Peptides
; 136: 170440, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33171278
10.
Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection.
Commun Biol
; 4(1): 926, 2021 07 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34326460
11.
The G Protein Biased Small Molecule Apelin Agonist CMF-019 is Disease Modifying in Endothelial Cell Apoptosis In Vitro and Induces Vasodilatation Without Desensitisation In Vivo.
Front Pharmacol
; 11: 588669, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33716722
12.
Apelin peptides linked to anti-serum albumin domain antibodies retain affinity in vitro and are efficacious receptor agonists in vivo.
Basic Clin Pharmacol Toxicol
; 126 Suppl 6: 96-103, 2020 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-30901161
13.
Enhanced selectivity, cellular uptake, and in vitro activity of an intrinsically fluorescent copper-tirapazamine nanocomplex for hypoxia targeted therapy in prostate cancer.
Biomater Sci
; 8(9): 2420-2433, 2020 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32236169
14.
Apelin-36-[L28A] and Apelin-36-[L28C(30kDa-PEG)] peptides that improve diet induced obesity are G protein biased ligands at the apelin receptor.
Peptides
; 121: 170139, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31472173
15.
Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr1]apelin-13 in humans.
Sci Rep
; 9(1): 19934, 2019 12 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31882594
16.
A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension.
Br J Pharmacol
; 176(9): 1206-1221, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30710493