Detalhe da pesquisa
1.
Pharmacokinetic, biodistribution, and biophysical profiles of TNF nanobodies conjugated to linear or branched poly(ethylene glycol).
Bioconjug Chem
; 23(7): 1452-62, 2012 Jul 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22731748
2.
Distinct in vitro binding properties of the anti-CD20 small modular immunopharmaceutical 2LM20-4 result in profound and sustained in vivo potency in cynomolgus monkeys.
Rheumatology (Oxford)
; 50(6): 1033-44, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21258049
3.
Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1.
Neuron
; 41(4): 587-98, 2004 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-14980207
4.
Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
Protein Sci
; 17(1): 16-21, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18042673
5.
Interleukin-13 neutralization by two distinct receptor blocking mechanisms reduces immunoglobulin E responses and lung inflammation in cynomolgus monkeys.
J Pharmacol Exp Ther
; 325(3): 882-92, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18337474
6.
Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer.
Antibodies (Basel)
; 5(1)2016 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31557987
7.
CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery.
MAbs
; 5(6): 882-95, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23995618
8.
Improving the pharmacokinetic properties of biologics by fusion to an anti-HSA shark VNAR domain.
MAbs
; 4(6): 673-85, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23676205
9.
Oligomerization is required for the activity of recombinant soluble LOX-1.
FEBS J
; 276(17): 4909-20, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19664054
10.
Characterization of protein kinase C theta activation loop autophosphorylation and the kinase domain catalytic mechanism.
Biochemistry
; 44(28): 9563-73, 2005 Jul 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-16008341
11.
Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187.
Proc Natl Acad Sci U S A
; 100(19): 10629-34, 2003 Sep 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-12963818
12.
Elongation of synthetic RNA templates by hepatitis C virus NS5B polymerase.
J Biol Chem
; 279(11): 10738-46, 2004 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-14688285
13.
Identification of constrained peptides that bind to and preferentially inhibit the activity of the hepatitis C viral RNA-dependent RNA polymerase.
Virology
; 313(1): 158-69, 2003 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12951030
14.
Catalytic domain crystal structure of protein kinase C-theta (PKCtheta).
J Biol Chem
; 279(48): 50401-9, 2004 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-15364937