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1.
Skeletal Radiol ; 50(5): 921-925, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-33021682

RESUMO

OBJECTIVE: To determine the prevalence of shoulder (specifically labral) abnormalities on MRI in a young non-athletic asymptomatic cohort. We hypothesize that this population will have fewer labral abnormalities than an athletic population. MATERIALS AND METHODS: In this cross-sectional study, non-athletic young adults age 18-29 with no history of shoulder pain received bilateral shoulder MRIs. A total of 58 total shoulder MRIs were completed on a 3-T MRI scanner (PRISMA-Fit Siemens Medical). MRIs were read by two board-certified fellowship-trained musculoskeletal radiologists at two time points 3 months apart to determine prevalence of labral and other shoulder anatomy abnormalities. Kappa statistics and the associated 95% confidence intervals were computed for inter/intra-reader reliability. Fisher's exact test was used to compare rates of abnormalities in our study with a similarly designed study involving ice hockey athletes. RESULTS: Prevalence of labral abnormalities was 9% (5/58). Kappa coefficient was 1.0 for both readers for intra-reader reliability and 0.57 for inter-reader reliability of labral abnormalities. We further compared our results in asymptomatic athletes with previously published work using the same protocol at our institution. The prevalence of labral abnormalities on MRI in asymptomatic professional and collegiate ice hockey players (49 imaged shoulders) was 24%, which demonstrated a statistically significant (p value < 0.05) difference compared with our data with a p value of 0.03. CONCLUSIONS: Non-athletic young adults with no history of shoulder pain/injury had an overall prevalence of shoulder MRI abnormalities less than asymptomatic professional and collegiate ice hockey players in a similarly designed study.


Assuntos
Articulação do Ombro , Ombro , Adolescente , Adulto , Estudos Transversais , Humanos , Imageamento por Ressonância Magnética , Prevalência , Reprodutibilidade dos Testes , Articulação do Ombro/diagnóstico por imagem , Adulto Jovem
2.
Curr Sports Med Rep ; 20(8): 389-394, 2021 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-34357884

RESUMO

ABSTRACT: Ten percent of all premature deaths and 117 billion dollars in annual health care costs are attributable to physical inactivity in America. The positive impact exercise can have on overall health is irrefutable. While it is the responsibility of health care providers to assess and counsel for exercise, there are logistical, structural, and educational barriers preventing this counseling. A physical activity consultation clinic led by primary care sports medicine physicians would allow for focused exercise counseling by appropriately trained providers to motivated patients. While previously there have been many institutional and logistical barriers to establishing such a clinic, the COVID-19 pandemic has created a window of opportunity for doing so within a large academic medical center. This article reviews the importance of exercise on overall health, outlines the barriers for establishing a clinical experience dedicated to counseling for physical activity, and details how overcoming those barriers was facilitated by the COVID-19 pandemic.


Assuntos
COVID-19/epidemiologia , Doença Crônica/prevenção & controle , Aconselhamento , Exercício Físico , Promoção da Saúde/métodos , Pandemias , Medicina Esportiva , Humanos , SARS-CoV-2 , Estados Unidos/epidemiologia
3.
Int J Mol Sci ; 21(20)2020 Oct 20.
Artigo em Inglês | MEDLINE | ID: mdl-33092191

RESUMO

Recurrent concussions increase risk for persistent post-concussion symptoms, and may lead to chronic neurocognitive deficits. Little is known about the molecular pathways that contribute to persistent concussion symptoms. We hypothesized that salivary measurement of microribonucleic acids (miRNAs), a class of epitranscriptional molecules implicated in concussion pathophysiology, would provide insights about the molecular cascade resulting from recurrent concussions. This hypothesis was tested in a case-control study involving 13 former professional football athletes with a history of recurrent concussion, and 18 age/sex-matched peers. Molecules of interest were further validated in a cross-sectional study of 310 younger individuals with a history of no concussion (n = 230), a single concussion (n = 56), or recurrent concussions (n = 24). There was no difference in neurocognitive performance between the former professional athletes and their peers, or among younger individuals with varying concussion exposures. However, younger individuals without prior concussion outperformed peers with prior concussion on three balance assessments. Twenty salivary miRNAs differed (adj. p < 0.05) between former professional athletes and their peers. Two of these (miR-28-3p and miR-339-3p) demonstrated relationships (p < 0.05) with the number of prior concussions reported by younger individuals. miR-28-3p and miR-339-5p may play a role in the pathophysiologic mechanism involved in cumulative concussion effects.


Assuntos
Biomarcadores/metabolismo , Concussão Encefálica/genética , MicroRNAs/genética , Saliva/metabolismo , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Atletas/estatística & dados numéricos , Estudos de Casos e Controles , Criança , Estudos Transversais , Futebol Americano , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem
6.
Osteoarthr Cartil Open ; 6(3): 100484, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-38800822

RESUMO

Objective: Osteoarthritis affects over 5.4 million people in the United States. A common treatment is to perform intra-articular corticosteroid injections. However, the ideal steroid dose is unknown. This study aimed to pilot a corticosteroid injection protocol for primary glenohumeral OA. Methods: We conducted a double blinded randomized feasibility pilot study. Patients with primary osteoarthritis of the glenohumeral joint were recruited and randomized to receive 20 â€‹mg, 40 â€‹mg, or 80 â€‹mg of triamcinolone. The primary outcome was the feasibility of the protocol and change in the Shoulder Pain and Disability Index (SPADI) 6 months following injection. Results: 300 patients were screened for participation with 78 meeting inclusion criteria. 19 subjects completed the study. The most common reason for not participating was concern they would receive a smaller dose than previous injections. There was a 26% dropout rate, with 2 patients undergoing a total shoulder arthroplasty. There was no clinically significant difference (p â€‹= â€‹0.090) between the groups at 6-months for the SPADI although all treatment groups showed a reduction of SPADI from baseline at 6 months. There was one adverse event in the 20 â€‹mg group, with a patient experiencing facial flushing after the injection. Conclusion: We were successful in developing a feasible protocol. In the future excluding those who have received previous injections would be helpful for a higher enrollment rate. This patient concern highlights the need to complete clinical trials to guide medical decisions surrounding corticosteroid administration. NCT03586687.

7.
PLoS One ; 18(10): e0292675, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37815998

RESUMO

BACKGROUND: Beyond causing significant morbidity and cost, musculoskeletal injuries (MSKI) are among the most common reasons for primary care visits. A validated injury risk assessment tool for MSKI is conspicuously absent from current care. While motion capture (MC) systems are the current gold standard for assessing human motion, their disadvantages include large size, non-portability, high cost, and limited spatial resolution. As an alternative we introduce the Micro Doppler Radar (MDR); in contrast with MC, it is small, portable, inexpensive, and has superior spatial resolution capabilities. While Phase 1 testing has confirmed that MDR can identify individuals at high risk for MSKI, Phase 2 testing is still needed. Our aims are to 1) Use MDR technology and MC to identify individuals at high-risk for MSKI 2) Evaluate whether MDR has diagnostic accuracy superior to MC 3) Develop MDR algorithms that enhance accuracy and enable automation. METHODS AND FINDINGS: A case control study will compare the movement patterns of 125 ACL reconstruction patients to 125 healthy controls. This study was reviewed and approved by the Pennsylvania State University Human Research Protection Program (HRPP) on May 18, 2022, and the IRB approval number is STUDY00020118. The ACL group is used as a model for a "high risk" population as up to 24% will have a repeat surgery within 2 years. An 8-camera Motion Analysis MC system with Cortex 8 software to collect MC data. Components for the radar technology will be purchased, assembled, and packaged. A micro-doppler signature projection algorithm will determine correct classification of ACL versus healthy control. Our previously tested algorithm for processing the MDR data will be used to identify the two groups. Discrimination, sensitivity and specificity will be calculated to compare the accuracy of MDR to MC in identifying the two groups. CONCLUSIONS: We describe the rationale and methodology of a case-control study using novel MDR technology to detect individuals at high-risk for MSKI. We expect this novel approach to exhibit superior accuracy than the current gold standard. Future translational studies will determine utility in the context of clinical primary care.


Assuntos
Doenças Musculoesqueléticas , Radar , Humanos , Estudos de Casos e Controles , Fatores de Risco , Medição de Risco
8.
J Am Coll Radiol ; 20(11S): S433-S454, 2023 11.
Artigo em Inglês | MEDLINE | ID: mdl-38040463

RESUMO

Total knee arthroplasty is the most commonly performed joint replacement procedure in the United States. This manuscript will discuss the recommended imaging modalities for six clinical variants; 1. follow-up of symptomatic or asymptomatic patients with a total knee arthroplasty. Initial imaging, 2. Suspected infection after total knee arthroplasty. Additional imaging following radiographs, 3. Pain after total knee arthroplasty. Infection excluded. Suspect aseptic loosening or osteolysis or instability. Additional imaging following radiographs, 4. Pain after total knee arthroplasty. Suspect periprosthetic or hardware fracture. Additional imaging following radiographs, 5. Pain after total knee arthroplasty. Measuring component rotation. Additional imaging following radiographs, and 6. Pain after total knee arthroplasty. Suspect periprosthetic soft-tissue abnormality unrelated to infection, including quadriceps or patellar tendinopathy. Additional imaging following radiographs. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision process support the systematic analysis of the medical literature from peer reviewed journals. Established methodology principles such as Grading of Recommendations Assessment, Development, and Evaluation or GRADE are adapted to evaluate the evidence. The RAND/UCLA Appropriateness Method User Manual provides the methodology to determine the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where peer reviewed literature is lacking or equivocal, experts may be the primary evidentiary source available to formulate a recommendation.


Assuntos
Artroplastia do Joelho , Dor Crônica , Humanos , Artralgia/diagnóstico por imagem , Dor Crônica/diagnóstico por imagem , Diagnóstico por Imagem/métodos , Radiografia , Sociedades Médicas , Estados Unidos
9.
J Sport Health Sci ; 12(3): 369-378, 2023 05.
Artigo em Inglês | MEDLINE | ID: mdl-34461327

RESUMO

BACKGROUND: Recognizing sport-related concussion (SRC) is challenging and relies heavily on subjective symptom reports. An objective, biological marker could improve recognition and understanding of SRC. There is emerging evidence that salivary micro-ribonucleic acids (miRNAs) may serve as biomarkers of concussion; however, it remains unclear whether concussion-related miRNAs are impacted by exercise. We sought to determine whether 40 miRNAs previously implicated in concussion pathophysiology were affected by participation in a variety of contact and non-contact sports. Our goal was to refine a miRNA-based tool capable of identifying athletes with SRC without the confounding effects of exercise. METHODS: This case-control study harmonized data from concussed and non-concussed athletes recruited across 10 sites. Levels of salivary miRNAs within 455 samples from 314 individuals were measured with RNA sequencing. Within-subjects testing was used to identify and exclude miRNAs that changed with either (a) a single episode of exercise (166 samples from 83 individuals) or (b) season-long participation in contact sports (212 samples from 106 individuals). The miRNAs that were not impacted by exercise were interrogated for SRC diagnostic utility using logistic regression (172 samples from 75 concussed and 97 non-concussed individuals). RESULTS: Two miRNAs (miR-532-5p and miR-182-5p) decreased (adjusted p < 0.05) after a single episode of exercise, and 1 miRNA (miR-4510) increased only after contact sports participation. Twenty-three miRNAs changed at the end of a contact sports season. Two of these miRNAs (miR-26b-3p and miR-29c-3p) were associated (R > 0.50; adjusted p < 0.05) with the number of head impacts sustained in a single football practice. Among the 15 miRNAs not confounded by exercise or season-long contact sports participation, 11 demonstrated a significant difference (adjusted p < 0.05) between concussed and non-concussed participants, and 6 displayed moderate ability (area under curve > 0.70) to identify concussion. A single ratio (miR-27a-5p/miR-30a-3p) displayed the highest accuracy (AUC = 0.810, sensitivity = 82.4%, specificity = 73.3%) for differentiating concussed and non-concussed participants. Accuracy did not differ between participants with SRC and non-SRC (z = 0.5, p = 0.60). CONCLUSION: Salivary miRNA levels may accurately identify SRC when not confounded by exercise. Refinement of this approach in a large cohort of athletes could eventually lead to a non-invasive, sideline adjunct for SRC assessment.


Assuntos
Concussão Encefálica , Futebol Americano , MicroRNAs , Humanos , Saliva , Estudos de Casos e Controles , Concussão Encefálica/diagnóstico , Biomarcadores
10.
Prim Care ; 49(1): 131-143, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-35125153

RESUMO

Small joint, peritendinous, and myofascial injections can be used for both diagnostic and therapeutic purposes. This article reviews injections for carpal tunnel, first dorsal compartment, trigger finger, ganglion cysts, trigger point, and plantar fascia. Necessary equipment should be gathered before the procedure and informed consent should be obtained. Indications, contraindications, and possible complications should be reviewed. Complete understanding of anatomy before injection is paramount. The injection technique should minimize risk of infection. There are no evidence-based postinjection protocols, and outcomes vary depending on the site and medication injected.


Assuntos
Tendões , Humanos
11.
J Am Board Fam Med ; 35(6): 1230-1238, 2022 12 23.
Artigo em Inglês | MEDLINE | ID: mdl-36396415

RESUMO

BACKGROUND: Medicolegal dilemmas faced by Sports Medicine providers differ from those of other primary care physicians in type and frequency. Exotic, high-profile challenges are widely covered in the literature and offer guidance on how to navigate challenging situations. However, there is a gap in the literature on how to approach more mundane, but nevertheless common, medicolegal dilemmas. PURPOSE: The purpose of this article is to provide Sports Medicine providers simple tools for determining whether a course of action is legal or ethical and offer Sports Medicine educators a model for teaching these skills. METHODS: We searched U.S. federal and state law using the LexisNexis® database for laws regulating Sports Medicine practice, and PubMed for articles related to physician approaches to Sports Medicine legal and ethical challenges. Searches started with the term sports medicine, and included winnowing terms of ethics, ethical practice, ethical guidelines, law, and legal guidelines. We used current ethical practice guidelines followed by the American Medical Association and described in detail by Beauchamp and Childress. RESULTS: We offer a framework for how to approach legal challenges in Sports Medicine and apply it to four common scenarios that Sports Medicine physicians often face. We further suggest that the profession formally address this literature gap with a standardized curriculum in Sports Medicine law. CONCLUSION: A curriculum using this framework and clinical vignettes provides learners and practitioners with familiarity and confidence when legal and ethical challenges arise in Sports Medicine.


Assuntos
Medicina Esportiva , Humanos , Currículo
12.
J Neurotrauma ; 39(13-14): 923-934, 2022 07.
Artigo em Inglês | MEDLINE | ID: mdl-35412857

RESUMO

Concussion is a heterogeneous injury that relies predominantly on subjective symptom reports for patient assessment and treatment. Developing an objective, biological test could aid phenotypic categorization of concussion patients, leading to advances in personalized treatment. This prospective multi-center study employed saliva micro-ribonucleic acid (miRNA) levels to stratify 251 individuals with concussion into biological subgroups. Using miRNA biological clusters, our objective was to assess for differences in medical/demographic characteristics, symptoms, and functional measures of balance and cognition. The miRNAs that best defined each cluster were used to identify physiological pathways that characterized each cluster. The 251 participants (mean age: 18 ± 7 years; 57% male) were optimally grouped into 10 clusters based on 22 miRNA levels. The clusters differed in age (χ2 = 19.1, p = 0.024), days post-injury at the time of saliva collection (χ2 = 22.6; p = 0.007), and number of prior concussions (χ2 = 17.6, p = 0.040). The clusters also differed in symptom reports for fatigue (χ2 = 17.7; p = 0.039), confusion (χ2 = 22.3; p = 0.008), difficulty remembering (χ2 = 22.0; p = 0.009), and trouble falling asleep (χ2 = 17.2; p = 0.046), but not objective balance or cognitive performance (p > 0.05). The miRNAs that defined concussion clusters regulate 16 physiological pathways, including adrenergic signaling, estrogen signaling, fatty acid metabolism, GABAergic signaling, synaptic vesicle cycling, and transforming growth factor (TGF)-ß signaling. These results show that saliva miRNA levels may stratify individuals with concussion based on underlying biological perturbations that are relevant to both symptomology and pharmacological targets. If validated in a larger cohort, miRNA assessment could aid individualized, biology-driven concussion treatment.


Assuntos
Concussão Encefálica , MicroRNAs , Concussão Encefálica/psicologia , Feminino , Humanos , Masculino , Fenótipo , Estudos Prospectivos , Saliva
13.
BMC Sports Sci Med Rehabil ; 13(1): 84, 2021 Aug 04.
Artigo em Inglês | MEDLINE | ID: mdl-34348781

RESUMO

BACKGROUND: Little is known about the musculoskeletal (MSK) exam providers use during the Preparticipation Physical Examination (PPE). The primary aims of this study were to determine current practice with regards to the MSK screening exam, if goals are being met, and if there may be opportunities for improvement. METHODS: This cross-sectional survey-based study utilized a REDCap instrument that was distributed to members of the American Academy of Family Physicians (AAFP) and the American Medical Society for Sports Medicine (AMSSM). Questions focused on participant demographics and MSK exam practices for the PPE. Descriptive statistics were used. RESULTS: The study had a total of 616 participants with a response rate of 9 %. The majority of respondents (82 %) were familiar with the 4th Edition PPE Monograph and 80 % either moderately or strongly agreed that they use this as a guideline for their MSK screening exam. The 90 s MSK screening test was implemented by 52 % of the participants. The majority of participants use an orthopedic exam as part of their PPE (82 %). Ninety-two percent of participants felt satisfied that their MSK exam would screen for current injury, while only 42 % were satisfied that it effectively screened for future injury. 86 % of participants agree that the MSK exam should be performed, while 26 % said that they don't perform a physical exam at all. DISCUSSION: There is a lack of understanding of the PPE Monograph as there is wide variability in MSK screening techniques providers use despite the majority of participants being familiar with the guidelines described in the monograph. Additionally, providers don't believe that the MSK exam screens for future injury. CONCLUSIONS: The goals of the MSK portion of the 4th Edition PPE monograph are not adequately being met and there is a need for further research to validate screening exams for the prevention of MSK injury.

14.
J Fam Pract ; 70(2): 80;82;84;85, 2021 03.
Artigo em Inglês | MEDLINE | ID: mdl-33760897

RESUMO

A number of factors-including patient age and risk for recurrence-influence treatment choices. Here's a closer look at what to consider.


Assuntos
Tomada de Decisão Clínica , Luxação do Ombro/reabilitação , Luxação do Ombro/cirurgia , Humanos , Modalidades de Fisioterapia , Volta ao Esporte
15.
Perm J ; 252021 06 09.
Artigo em Inglês | MEDLINE | ID: mdl-35348075

RESUMO

BACKGROUND: The goal of the preparticipation physical examination (PPE) is to promote health and safety during competition by screening athletes for injuries and illness. Historically it has been reported that the PPE may be the only medical evaluation that many student athletes receive. Our objective was to evaluate whether student athletes who have participated in our PPEs also receive routine well child care. In addition, we investigated parental perspectives regarding what should be included during the PPE. METHODS: A 29-question survey was distributed to parents of student athletes during 6 PPE sessions sponsored and hosted at local school districts. Descriptive statistics were used to characterize and summarize the data set. RESULTS: A total of 288 surveys were completed. All our student athletes had a primary care provider (100%), with the overwhelming majority of student athletes (90.9%) having both a well child examination and a PPE annually. Approximately 89% of parents believed that electrocardiograms prevented sudden cardiac death in sports. The majority of parents believed the PPE was an appropriate setting to discuss mental health and substance abuse. CONCLUSION: The majority of student athletes complete both a well child examination and a PPE annually. Parents believe screening electrocardiograms are effective in preventing sudden cardiac death and that the PPE can prevent injuries from occurring. Parents also believe the PPE can serve as an opportunity to discuss mental health and substance abuse, which is consistent with the most recent PPE monogram. An educational handout should be provided to parents regarding the goals of the PPE.


Assuntos
Promoção da Saúde , Esportes , Atletas , Humanos , Exame Físico , Estudantes
16.
Gait Posture ; 85: 96-102, 2021 03.
Artigo em Inglês | MEDLINE | ID: mdl-33524666

RESUMO

BACKGROUND: Development of accessible cost-effective technology to objectively, reliably, and accurately predict musculoskeletal injury risk could aid the effort to prevent chronic pain and disability. Recent work on micro-Doppler radar suggests it merits investigation towards these goals. The micro-Doppler signals that are created can infer differences in gross movements such as walking versus crawling in military settings where direct vision is not possible. Unique micro-Doppler signals may be able to identify more subtle movement patterns which would not be easily seen by the human eye. RESEARCH QUESTION: Can micro Doppler radar predictably and accurately identify subtle differences in movement conditions? METHODS: This is a cross sectional study recruiting NCAA athletes to jump in front of the micro-Doppler radar barefoot, with shoes, and shoes with a heel lift. The micro-Doppler radar signature projection algorithm was developed to determine whether the radar is able to distinguish the three distinct movement patterns. RESULTS: Confusion matrices were used to visualize the performance of the support-vector machine at the 80/20 test/train split correctly classifying barefoot subjects, shoes and heel lift, and shoes correctly at 0° with respect to the radar 90.9 %, 86.7 %, and 89.5 % of the time, respectively. At 90° with respect to the radar, it was successful 94.1 %, 100 %, and 80 % of the time, respectively. CONCLUSION: This study suggests that the micro-Doppler radar signature projection algorithm is highly accurate and able to predict subtle differences in movement that are not readily observed with conventional motion capture systems. Future studies are needed to better understand if micro-Doppler signals can identify pathologic movement patterns or movement that is associated with increased risk of injury.


Assuntos
Algoritmos , Traumatismos em Atletas/prevenção & controle , Aprendizado de Máquina , Movimento/fisiologia , Radar , Ultrassonografia Doppler/métodos , Adolescente , Adulto , Traumatismos em Atletas/etiologia , Traumatismos em Atletas/fisiopatologia , Fenômenos Biomecânicos , Estudos Transversais , Humanos , Reprodutibilidade dos Testes , Medição de Risco , Adulto Jovem
17.
J Neurol ; 268(11): 4349-4361, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34028616

RESUMO

OBJECTIVE: The goals of this study were to assess the ability of salivary non-coding RNA (ncRNA) levels to predict post-concussion symptoms lasting ≥ 21 days, and to examine the ability of ncRNAs to identify recovery compared to cognition and balance. METHODS: RNA sequencing was performed on 505 saliva samples obtained longitudinally from 112 individuals (8-24-years-old) with mild traumatic brain injury (mTBI). Initial samples were obtained ≤ 14 days post-injury, and follow-up samples were obtained ≥ 21 days post-injury. Computerized balance and cognitive test performance were assessed at initial and follow-up time-points. Machine learning was used to define: (1) a model employing initial ncRNA levels to predict persistent post-concussion symptoms (PPCS) ≥ 21 days post-injury; and (2) a model employing follow-up ncRNA levels to identify symptom recovery. Performance of the models was compared against a validated clinical prediction rule, and balance/cognitive test performance, respectively. RESULTS: An algorithm using age and 16 ncRNAs predicted PPCS with greater accuracy than the validated clinical tool and demonstrated additive combined utility (area under the curve (AUC) 0.86; 95% CI 0.84-0.88). Initial balance and cognitive test performance did not differ between PPCS and non-PPCS groups (p > 0.05). Follow-up balance and cognitive test performance identified symptom recovery with similar accuracy to a model using 11 ncRNAs and age. A combined model (ncRNAs, balance, cognition) most accurately identified recovery (AUC 0.86; 95% CI 0.83-0.89). CONCLUSIONS: ncRNA biomarkers show promise for tracking recovery from mTBI, and for predicting who will have prolonged symptoms. They could provide accurate expectations for recovery, stratify need for intervention, and guide safe return-to-activities.


Assuntos
Concussão Encefálica , Adolescente , Adulto , Biomarcadores , Concussão Encefálica/diagnóstico , Criança , Humanos , Testes Neuropsicológicos , RNA , Saliva , Adulto Jovem
19.
Clin Transl Med ; 10(6): e197, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-33135344

RESUMO

BACKGROUND: Early, accurate diagnosis of mild traumatic brain injury (mTBI) can improve clinical outcomes for patients, but mTBI remains difficult to diagnose because of reliance on subjective symptom reports. An objective biomarker could increase diagnostic accuracy and improve clinical outcomes. The aim of this study was to assess the ability of salivary noncoding RNA (ncRNA) to serve as a diagnostic adjunct to current clinical tools. We hypothesized that saliva ncRNA levels would demonstrate comparable accuracy for identifying mTBI as measures of symptom burden, neurocognition, and balance. METHODS: This case-control study involved 538 individuals. Participants included 251 individuals with mTBI, enrolled ≤14 days postinjury, from 11 clinical sites. Saliva samples (n = 679) were collected at five time points (≤3, 4-7, 8-14, 15-30, and 31-60 days post-mTBI). Levels of ncRNAs (microRNAs, small nucleolar RNAs, and piwi-interacting RNAs) were quantified within each sample using RNA sequencing. The first sample from each mTBI participant was compared to saliva samples from 287 controls. Samples were divided into testing (n = 430; mTBI = 201 and control = 239) and training sets (n = 108; mTBI = 50 and control = 58). The test set was used to identify ncRNA diagnostic candidates and create a diagnostic model. Model accuracy was assessed in the naïve test set. RESULTS: A model utilizing seven ncRNA ratios, along with participant age and chronic headache status, differentiated mTBI and control participants with a cross-validated area under the curve (AUC) of .857 in the training set (95% CI, .816-.903) and .823 in the naïve test set. In a subset of participants (n = 321; mTBI = 176 and control = 145) assessed for symptom burden (Post-Concussion Symptom Scale), as well as neurocognition and balance (ClearEdge System), these clinical measures yielded cross-validated AUC of .835 (95% CI, .782-.880) and .853 (95% CI, .803-.899), respectively. A model employing symptom burden and four neurocognitive measures identified mTBI participants with similar AUC (.888; CI, .845-.925) as symptom burden and four ncRNAs (.932; 95% CI, .890-.965). CONCLUSION: Salivary ncRNA levels represent a noninvasive, biologic measure that can aid objective, accurate diagnosis of mTBI.

20.
Sports Health ; 11(1): 64-68, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30289744

RESUMO

BACKGROUND:: Pediatric sports specialization, defined as intense year-round training in a single sport as a result of excluding other sports for more than 8 months per year, is common in the United States. There are demonstrated physical and social risks to early pediatric sports specialization (defined as before age 12 years). While thought to be needed to acquire appropriate experience and excel in a given sport, there remains little information on when athletes at the highest levels of their sport specialized. This study aimed to define when professional and collegiate ice hockey players specialized. HYPOTHESIS:: Early sports specialization before age 12 years will not be common among elite-level (professional and collegiate) ice hockey players. STUDY DESIGN:: Retrospective cross-sectional survey study. LEVEL OF EVIDENCE:: Level 3. METHODS:: Male professional and collegiate ice hockey players within 1 National Hockey League organization and 2 National Collegiate Athletic Association (NCAA) organizations who were 18 years of age or older completed a survey at training camp detailing their history of sports participation and specialization. RESULTS:: A total of 91 athletes participated in the study (mean age, 22.8 years; range, 18-39 years). The mean age at the start of any sports participation was 4.5 years, and the mean age of sports specialization was 14.3 years. The mean age of specialization in the professional group, the NCAA Division I group, and the NCAA Division III group was 14.1, 14.5, and 14.6 years, respectively. CONCLUSION:: Early pediatric sports specialization is not common in elite-level (professional and collegiate) ice hockey players. CLINICAL RELEVANCE:: Early pediatric sports specialization before age 12 years is not necessary for athletic success in professional and collegiate ice hockey. This study provides further evidence supporting the recommendations of the American Medical Society for Sports Medicine, American Academy of Pediatrics, and American Orthopaedic Society for Sports Medicine against early sports specialization.


Assuntos
Desempenho Atlético , Hóquei , Especialização , Adolescente , Adulto , Fatores Etários , Criança , Estudos Transversais , Humanos , Masculino , Condicionamento Físico Humano , Estudos Retrospectivos , Estados Unidos , Adulto Jovem
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