Detalhe da pesquisa
1.
Direct-to-biology platform: From synthesis to biological evaluation of SHP2 allosteric inhibitors.
Bioorg Med Chem Lett
; 100: 129626, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38266789
2.
SAR evolution towards potent C-terminal carboxamide peptide inhibitors of Zika virus NS2B-NS3 protease.
Bioorg Med Chem
; 57: 116631, 2022 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35123179
3.
Discovery of 4-((1-(1H-imidazol-2-yl)alkoxy)methyl)pyridines as a new class of Trypanosoma cruzi growth inhibitors.
Bioorg Med Chem Lett
; 30(8): 127052, 2020 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32113841
4.
Optimization of 2-(1H-imidazo-2-yl)piperazines series of Trypanosoma brucei growth inhibitors as potential treatment for the second stage of HAT.
Bioorg Med Chem Lett
; 30(12): 127207, 2020 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32354566
5.
Discovery of 2-(1H-imidazo-2-yl)piperazines as a new class of potent and non-cytotoxic inhibitors of Trypanosoma brucei growth in vitro.
Bioorg Med Chem Lett
; 28(23-24): 3689-3692, 2018 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30482621
6.
Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors.
ACS Med Chem Lett
; 14(2): 156-162, 2023 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36793438
7.
N-(2-alkylaminoethyl)-4-(1,2,4-oxadiazol-5-yl)piperazine-1-carboxamides as highly potent smoothened antagonists.
Bioorg Med Chem Lett
; 21(18): 5283-8, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21802943
8.
Identification of a series of 4-[3-(quinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperazinyl ureas as potent smoothened antagonist hedgehog pathway inhibitors.
Bioorg Med Chem Lett
; 21(18): 5274-82, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21803580
9.
Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1).
Bioorg Med Chem Lett
; 20(2): 448-52, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20015648
10.
Synthesis and biological evaluation of substituted 2-phenyl-2H-indazole-7-carboxamides as potent poly(ADP-ribose) polymerase (PARP) inhibitors.
Bioorg Med Chem Lett
; 20(2): 488-92, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20007017
11.
Allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain site II: structure-based design and synthesis of new templates.
Bioorg Med Chem
; 18(8): 2836-48, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20363140
12.
Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction.
ACS Med Chem Lett
; 11(5): 740-746, 2020 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32435379
13.
Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model.
Bioorg Med Chem Lett
; 19(11): 3081-4, 2009 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19410459
14.
Identification of substituted pyrazolo[1,5-a]quinazolin-5(4H)-one as potent poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors.
Bioorg Med Chem Lett
; 19(15): 4196-200, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19541484
15.
Improved Selective Class I HDAC and Novel Selective HDAC3 Inhibitors: Beyond Hydroxamic Acids and Benzamides.
ACS Med Chem Lett
; 10(4): 481-486, 2019 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30996783
16.
Studies of the metabolic stability in cells of 5-(trifluoroacetyl)thiophene-2-carboxamides and identification of more stable class II histone deacetylase (HDAC) inhibitors.
Bioorg Med Chem Lett
; 18(23): 6078-82, 2008 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18952417
17.
2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors.
Bioorg Med Chem Lett
; 18(11): 3456-61, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18440229
18.
Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs.
ACS Med Chem Lett
; 7(5): 454-9, 2016 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27190592
19.
The design and enzyme-bound crystal structure of indoline based peptidomimetic inhibitors of hepatitis C virus NS3 protease.
J Med Chem
; 47(26): 6443-6, 2004 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-15588076
20.
Identification of novel, selective, and stable inhibitors of class II histone deacetylases. Validation studies of the inhibition of the enzymatic activity of HDAC4 by small molecules as a novel approach for cancer therapy.
J Med Chem
; 52(21): 6782-9, 2009 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-19888759