Detalhe da pesquisa
1.
Statin-based endothelial prophylaxis and outcome after allogeneic stem cell transplantation.
Eur J Clin Invest
; 53(2): e13883, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-36199203
2.
Subcutaneous catabolism of peptide therapeutics: bioanalytical approaches and ADME considerations.
Xenobiotica
; 52(8): 828-839, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-36039395
3.
Personalized Metabolic Profile by Synergic Use of NMR and HRMS.
Molecules
; 26(14)2021 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34299442
4.
Comparison of different protein precipitation and solid-phase extraction protocols for the study of the catabolism of peptide drugs by LC-HRMS.
J Pept Sci
; 26(9): e3272, 2020 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-32633064
5.
Application of an in Vitro Blood-Brain Barrier Model in the Selection of Experimental Drug Candidates for the Treatment of Huntington's Disease.
Mol Pharm
; 16(5): 2069-2082, 2019 05 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30916978
6.
An efficient liquid chromatography-high resolution mass spectrometry approach for the optimization of the metabolic stability of therapeutic peptides.
Anal Bioanal Chem
; 409(10): 2685-2696, 2017 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-28138743
7.
The Urine Metabolome of R6/2 and zQ175DN Huntington's Disease Mouse Models.
Metabolites
; 13(8)2023 Aug 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37623904
8.
Fatty acid acylated peptide therapeutics: discovery of omega-n oxidation of the lipid chain as a novel metabolic pathway in preclinical species.
J Pharm Biomed Anal
; 227: 115256, 2023 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36764268
9.
Design and Evaluation of [18F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates.
J Med Chem
; 66(1): 641-656, 2023 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36548390
10.
Oligomerization, albumin binding and catabolism of therapeutic peptides in the subcutaneous compartment: An investigation on lipidated GLP-1 analogs.
J Pharm Biomed Anal
; 210: 114566, 2022 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35042144
11.
Generation and selection of novel fully human monoclonal antibodies that neutralize Dickkopf-1 (DKK1) inhibitory function in vitro and increase bone mass in vivo.
J Biol Chem
; 285(51): 40135-47, 2010 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-20929859
12.
A proprotein convertase subtilisin-like/kexin type 9 (PCSK9) C-terminal domain antibody antigen-binding fragment inhibits PCSK9 internalization and restores low density lipoprotein uptake.
J Biol Chem
; 285(17): 12882-91, 2010 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-20172854
13.
Kynurenine pathway activation and deviation to anthranilic and kynurenic acid in fibrosing chronic graft-versus-host disease.
Cell Rep Med
; 2(10): 100409, 2021 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34755129
14.
Turnover rate of coenzyme A in mouse brain and liver.
PLoS One
; 16(5): e0251981, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34019583
15.
Identification of Potent and Long-Acting Single-Chain Peptide Mimetics of Human Relaxin-2 for Cardiovascular Diseases.
J Med Chem
; 64(4): 2139-2150, 2021 02 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33555858
16.
[11C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins.
J Med Chem
; 64(16): 12003-12021, 2021 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34351166
17.
Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand.
J Med Chem
; 63(15): 8608-8633, 2020 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32662649
18.
Ezrin is a specific and direct target of protein tyrosine phosphatase PRL-3.
Biochim Biophys Acta
; 1783(2): 334-44, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18078820
19.
2-D Difference in gel electrophoresis combined with Pro-Q Diamond staining: a successful approach for the identification of kinase/phosphatase targets.
Electrophoresis
; 30(14): 2469-76, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19639567
20.
Mass spectrometry study of PRL-3 phosphatase inactivation by disulfide bond formation and cysteine into glycine conversion.
Rapid Commun Mass Spectrom
; 23(17): 2733-40, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19639556