1.
Bioorg Med Chem Lett
; 22(3): 1427-32, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22226655
RESUMO
In this Letter we describe the optimization of an aminopurine lead (1) with modest potency and poor overall kinase selectivity which led to the identification of a series of potent, selective JNK inhibitors. Improvement in kinase selectivity was enabled by introduction of an aliphatic side chain at the C-2 position. CC-359 (2) was selected as a potential clinical candidate for diseases manifested by ischemia reperfusion injury.