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1.
Acad Radiol ; 12(11): 1385-93, 2005 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-16253850

RESUMO

RATIONALE AND OBJECTIVES: To investigate changes in lung microstructure in healthy adult subjects with no smoking history using diffusion-weighted 3He MRI. MATERIALS AND METHODS: Diffusion magnetic resonance imaging using hyperpolarized helium 3 (3He) was applied to healthy volunteers to explore the dependence of lung microstructural changes with age, reflected by changes in the apparent diffusion coefficient (ADC) of 3He in lung air spaces. Data from three sites (University of Virginia (UVa), N = 25; University of Wisconsin (UW), N = 8; University of Nottingham (UN), N = 11) were combined in pooled analysis, including a total of N = 44 subjects (age range, 18-69 years; average age, 41.7 +/- 16.7 years). RESULTS: ADC was found to depend on age at all three sites (UW, R = +0.95, P = .0003; UVa, R = +0.74, P < .0001; UN, R = +0.96, P < .0001). Increases in mean ADCs with age appeared similar across sites (UW, +0.0017 cm2 s(-1) y(-1); UVa, +0.0015 cm2 s(-1) y(-1); pooled, +0.0015 cm2 s(-1) y(-1); P = .71). In a regional analysis performed on UW data, the increase in ADC affected all regions of the lung, but the apical and middle regions showed a greater increase compared with the base of the lung. CONCLUSION: Results suggest the observed age dependence of the ADC may be caused by changes in lung microstructure that increase alveolar volume during the aging process.


Assuntos
Envelhecimento/fisiologia , Imagem de Difusão por Ressonância Magnética , Hélio , Pulmão/fisiologia , Adolescente , Adulto , Idoso , Envelhecimento/patologia , Feminino , Humanos , Isótopos , Pulmão/anatomia & histologia , Masculino , Pessoa de Meia-Idade , Capacidade de Difusão Pulmonar
2.
Radiology ; 239(3): 875-83, 2006 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-16714465

RESUMO

PURPOSE: To prospectively compare apparent diffusion coefficient (ADC) measurements derived from diffusion-weighted hyperpolarized helium 3 (3He) magnetic resonance (MR) imaging with functional and structural findings using spirometric tests and thin-section computed tomography (CT) of the lungs in asymptomatic smokers and healthy nonsmokers of similar age. MATERIALS AND METHODS: All studies were HIPAA compliant and were approved by the institutional review board. Informed consent was obtained. Ventilation and diffusion-weighted 3He MR images were obtained in healthy subjects: 11 smokers (five women, six men; mean age, 47 years+/-18 [standard deviation]; range, 23-73 years) and eight nonsmokers (<100 cigarettes in lifetime) (four women, four men; mean age, 46 years+/-16; range, 23-69 years). Mean ADC values for smokers and nonsmokers were compared with spirometric values, diffusing capacity of the lung for carbon monoxide (Dlco), age, and pack-years with Spearman rank correlation coefficient (rs) and multiple linear regression analysis. Mean ADC value and thin-section CT emphysema index of relative area less than -950 HU (RA950) were compared on a regional basis by using linear mixed-effect models. RESULTS: Mean ADC values and number of pack-years were significantly correlated (rs=0.60; 95% confidence interval (CI): 0.21, 1.00; P=.007); relationship remained significant after adjustment for age (P=.003). Dlco was strongly correlated with pack-years (rs=-0.63; 95% CI: -0.97, -0.29; P=.004). Negative correlations between mean ADC values and percentage predicted Dlco (rs=-0.79; 95% CI: -0.93, -0.64; P<.001) and the ratio of forced expiratory volume in 1 second to forced vital capacity (rs=-0.72; 95% CI: -0.92, -0.52; P=.001) were statistically significant. Correlations between spirometric values or RA950 and number of pack-years were not significant (.05 level). CONCLUSION: Correlations between mean ADC values and pulmonary function test measurements for diagnosing emphysema, especially Dlco, were statistically significant.


Assuntos
Imagem de Difusão por Ressonância Magnética/métodos , Enfisema Pulmonar/diagnóstico , Fumar , Adolescente , Adulto , Fatores Etários , Idoso , Monóxido de Carbono , Diagnóstico Precoce , Feminino , Volume Expiratório Forçado/fisiologia , Hélio , Humanos , Processamento de Imagem Assistida por Computador/métodos , Isótopos , Pulmão/fisiopatologia , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Capacidade de Difusão Pulmonar/fisiologia , Enfisema Pulmonar/fisiopatologia , Fumar/fisiopatologia , Espirometria , Tomografia Computadorizada por Raios X/métodos , Capacidade Vital/fisiologia
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