Detalhe da pesquisa
1.
Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction.
Bioorg Med Chem
; 28(21): 115738, 2020 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33065433
2.
Age- and sex-related changes in cortical and striatal nitric oxide synthase in the Q175 mouse model of Huntington's disease.
Nitric Oxide
; 83: 40-50, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30528913
3.
Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated protein 1 (KEAP1).
Arch Biochem Biophys
; 631: 31-41, 2017 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28801166
4.
HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.
PLoS Biol
; 11(11): e1001717, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24302884
5.
A novel BACHD transgenic rat exhibits characteristic neuropathological features of Huntington disease.
J Neurosci
; 32(44): 15426-38, 2012 Oct 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-23115180
6.
Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment.
J Neurosci
; 32(22): 7454-65, 2012 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-22649225
7.
Extramedullary plasmacytoma of the oral cavity metastasising to both kidneys in a dog.
Vet Med Sci
; 9(3): 1053-1061, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36748292
8.
Global Rhes knockout in the Q175 Huntington's disease mouse model.
PLoS One
; 16(10): e0258486, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34648564
9.
HDinHD: A Rich Data Portal for Huntington's Disease Research.
J Huntingtons Dis
; 10(3): 405-412, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34397420
10.
NRF2 activation by reversible KEAP1 binding induces the antioxidant response in primary neurons and astrocytes of a Huntington's disease mouse model.
Free Radic Biol Med
; 162: 243-254, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33096251
11.
Rapid and robust patterns of spontaneous locomotor deficits in mouse models of Huntington's disease.
PLoS One
; 15(12): e0243052, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33370315
12.
Transcriptional Assessment of Striatal mRNAs as Valid Biomarkers of Disease Progression in Three Mouse Models of Huntington's Disease.
J Huntingtons Dis
; 9(1): 13-31, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32007959
13.
Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction.
ACS Med Chem Lett
; 11(5): 740-746, 2020 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32435379
14.
Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models.
Neurobiol Dis
; 35(3): 319-36, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19464370
15.
Improved synthesis of [18F] fallypride and characterization of a Huntington's disease mouse model, zQ175DN KI, using longitudinal PET imaging of D2/D3 receptors.
EJNMMI Radiopharm Chem
; 4(1): 20, 2019 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31659519
16.
Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington's disease.
Nat Med
; 25(7): 1131-1142, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31263285
17.
c-Jun N-terminal kinases mediate reactivation of Akt and cardiomyocyte survival after hypoxic injury in vitro and in vivo.
Circ Res
; 98(1): 111-8, 2006 Jan 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-16306447
18.
Impaired Performance of the Q175 Mouse Model of Huntington's Disease in the Touch Screen Paired Associates Learning Task.
Front Behav Neurosci
; 12: 226, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30333735
19.
Novel Metabolic Abnormalities in the Tricarboxylic Acid Cycle in Peripheral Cells From Huntington's Disease Patients.
PLoS One
; 11(9): e0160384, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27611087
20.
The novel KMO inhibitor CHDI-340246 leads to a restoration of electrophysiological alterations in mouse models of Huntington's disease.
Exp Neurol
; 282: 99-118, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27163548