Detalhe da pesquisa
1.
Cystic Fibrosis Transmembrane Conductance Regulator Attaches Tumor Suppressor PTEN to the Membrane and Promotes Anti Pseudomonas aeruginosa Immunity.
Immunity
; 47(6): 1169-1181.e7, 2017 12 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29246444
2.
Acetylation Targeting Chimera Enables Acetylation of the Tumor Suppressor p53.
J Am Chem Soc
; 145(27): 14932-14944, 2023 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37365684
3.
Discovery of a first-in-class EZH2 selective degrader.
Nat Chem Biol
; 16(2): 214-222, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31819273
4.
Cooperation Between Distinct Cancer Driver Genes Underlies Intertumor Heterogeneity in Hepatocellular Carcinoma.
Gastroenterology
; 159(6): 2203-2220.e14, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32814112
5.
PTEN interacts with the transcription machinery on chromatin and regulates RNA polymerase II-mediated transcription.
Nucleic Acids Res
; 47(11): 5573-5586, 2019 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31169889
6.
Survival factor NFIL3 restricts FOXO-induced gene expression in cancer.
Genes Dev
; 27(8): 916-27, 2013 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23630076
7.
PTEN function: the long and the short of it.
Trends Biochem Sci
; 39(4): 183-90, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24656806
8.
Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.
Mol Cell
; 40(6): 877-92, 2010 Dec 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-21172654
9.
PREX1 Protein Function Is Negatively Regulated Downstream of Receptor Tyrosine Kinase Activation by p21-activated Kinases (PAKs).
J Biol Chem
; 291(38): 20042-54, 2016 09 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27481946
10.
Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis.
Proc Natl Acad Sci U S A
; 111(1): 155-60, 2014 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24367090
11.
p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase.
J Biol Chem
; 290(48): 28915-31, 2015 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-26438819
12.
Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer.
BMC Cancer
; 16: 587, 2016 08 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27484095
13.
Analysis of intracellular PTEN signaling and secretion.
Methods
; 77-78: 164-71, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25462559
14.
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia.
Nat Med
; 13(10): 1203-10, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17873882
15.
Differential histone acetylation and super-enhancer regulation underlie melanoma cell dedifferentiation.
JCI Insight
; 9(6)2024 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38319712
16.
Lack of PTEN sequesters CHK1 and initiates genetic instability.
Cancer Cell
; 7(2): 193-204, 2005 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-15710331
17.
Etiology of super-enhancer reprogramming and activation in cancer.
Epigenetics Chromatin
; 16(1): 29, 2023 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37415185
18.
Molecular mechanisms in colitis-associated colorectal cancer.
Oncogenesis
; 12(1): 48, 2023 Oct 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37884500
19.
In vivo RNA-seq and ChIP-seq analyses show an obligatory role for the C terminus of p53 in conferring tissue-specific radiation sensitivity.
Cell Rep
; 42(3): 112216, 2023 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36924496
20.
Ex vivo reprogramming of human hematopoietic stem cells is accompanied by increased transcripts of genes regulating metabolic integrity.
Exp Hematol
; 122: 41-54, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37001723