Detalhe da pesquisa
1.
Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.
J Biol Chem
; 299(12): 105382, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37866628
2.
Identification of Covalent Cyclic Peptide Inhibitors in mRNA Display.
J Am Chem Soc
; 145(28): 15065-15070, 2023 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37395736
3.
A High-Throughput Assay to Identify Allosteric Inhibitors of the PLC-γ Isozymes Operating at Membranes.
Biochemistry
; 59(41): 4029-4038, 2020 10 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33028071
4.
Design and Construction of a Focused DNA-Encoded Library for Multivalent Chromatin Reader Proteins.
Molecules
; 25(4)2020 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32098353
5.
DNA methylation status predicts cell type-specific enhancer activity.
EMBO J
; 30(15): 3028-39, 2011 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-21701563
6.
Discovery of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach.
bioRxiv
; 2024 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38562906
7.
Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM.
PLoS One
; 19(2): e0293548, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38359047
8.
Machine Learning-driven Fragment-based Discovery of CIB1-directed Anti-Tumor Agents by FRASE-bot.
Res Sq
; 2023 Aug 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37645935
9.
Development of a high-throughput TR-FRET screening assay for a fast-cycling KRAS mutant.
SLAS Discov
; 28(1): 39-47, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36563789
10.
SETDB1 Triple Tudor Domain Ligand, (R,R)-59, Promotes Methylation of Akt1 in Cells.
ACS Chem Biol
; 18(8): 1846-1853, 2023 08 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37556795
11.
Fused Tetrahydroquinolines Are Interfering with Your Assay.
J Med Chem
; 66(21): 14434-14446, 2023 11 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37874947
12.
SETDB1 Triple Tudor Domain Ligand, ( R,R )-59, Promotes Methylation of Akt1 in Cells.
bioRxiv
; 2023 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37214894
13.
PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components.
ACS Chem Biol
; 18(3): 494-507, 2023 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36877831
14.
Discovery of a 53BP1 Small Molecule Antagonist Using a Focused DNA-Encoded Library Screen.
J Med Chem
; 66(20): 14133-14149, 2023 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37782247
15.
Development of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic strategy for Alzheimer's disease.
bioRxiv
; 2023 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37292860
16.
Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM.
bioRxiv
; 2023 Jul 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37547005
17.
Development of Novel IP6K Inhibitors for the Treatment of Obesity and Obesity-Induced Metabolic Dysfunctions.
J Med Chem
; 65(9): 6869-6887, 2022 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35467861
18.
Discovery and Structural Basis of the Selectivity of Potent Cyclic Peptide Inhibitors of MAGE-A4.
J Med Chem
; 65(10): 7231-7245, 2022 05 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35522528
19.
Discovery of Potent Peptidomimetic Antagonists for Heterochromatin Protein 1 Family Proteins.
ACS Omega
; 7(1): 716-732, 2022 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35036738
20.
Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library.
SLAS Discov
; 27(8): 428-439, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36272689