Pesquisa | BVS Integralidade em Saúde

1.

Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors.

Cumming, Iain A; Degorce, Sébastien L; Aagaard, Anna; Braybrooke, Erin L; Davies, Nichola L; Diène, Coura R; Eatherton, Andrew J; Felstead, Hannah R; Groombridge, Sam D; Lenz, Eva M; Li, Yunxia; Nai, Youfeng; Pearson, Stuart; Robb, Graeme R; Scott, James S; Steward, Oliver R; Wu, Chengyan; Xue, Yafeng; Zhang, Lanping; Zhang, Yanxiu.

Bioorg Med Chem ; 63: 116729, 2022 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-35439688

2.

A brief diagnostic screen for cluster headache: Creation and initial validation of the Erwin Test for Cluster Headache.

Parakramaweera, Randika; Evans, Randolph W; Schor, Larry I; Pearson, Stuart M; Martinez, Rebecca; Cammarata, Jacob S; Amin, Amisha J; Yoo, Seung-Hee; Zhang, Wei; Yan, Yuanqing; Burish, Mark J.

Cephalalgia ; 41(13): 1298-1309, 2021 11.

Artigo em Inglês | MEDLINE | ID: mdl-34148408

3.

Cluster headache is one of the most intensely painful human conditions: Results from the International Cluster Headache Questionnaire.

Burish, Mark J; Pearson, Stuart M; Shapiro, Robert E; Zhang, Wei; Schor, Larry I.

Headache ; 61(1): 117-124, 2021 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-33337540

4.

Cluster headache epidemiology including pediatric onset, sex, and ICHD criteria: Results from the International Cluster Headache Questionnaire.

Schor, Larry I; Pearson, Stuart M; Shapiro, Robert E; Zhang, Wei; Miao, Hongyu; Burish, Mark J.

Headache ; 61(10): 1511-1520, 2021 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-34841518

5.

Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors.

Degorce, Sébastien L; Aagaard, Anna; Anjum, Rana; Cumming, Iain A; Diène, Coura R; Fallan, Charlene; Johnson, Tony; Leuchowius, Karl-Johan; Orton, Alexandra L; Pearson, Stuart; Robb, Graeme R; Rosen, Alan; Scarfe, Graeme B; Scott, James S; Smith, James M; Steward, Oliver R; Terstiege, Ina; Tucker, Michael J; Turner, Paul; Wilkinson, Stephen D; Wrigley, Gail L; Xue, Yafeng.

Bioorg Med Chem ; 28(23): 115815, 2020 12 01.

Artigo em Inglês | MEDLINE | ID: mdl-33091850

6.

Effectiveness of Oxygen and Other Acute Treatments for Cluster Headache: Results From the Cluster Headache Questionnaire, an International Survey.

Pearson, Stuart M; Burish, Mark J; Shapiro, Robert E; Yan, Yuanqing; Schor, Larry I.

Headache ; 59(2): 235-249, 2019 02.

Artigo em Inglês | MEDLINE | ID: mdl-30632614

7.

Oxygen as the Optimal Acute Medication for Cluster Headache: A Comment and Additional Validation Step From the Cluster Headache Questionnaire.

Burish, Mark J; Pearson, Stuart M; Shapiro, Robert E; Zhang, Wei; Schor, Larry I.

Headache ; 60(10): 2592-2593, 2020 11.

Artigo em Inglês | MEDLINE | ID: mdl-32935343

8.

A new series of neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase.

Barlaam, Bernard; Ballard, Peter; Bradbury, Robert H; Ducray, Richard; Germain, Hervé; Hickinson, D Mark; Hudson, Kevin; Kettle, Jason G; Klinowska, Teresa; Magnien, Françoise; Ogilvie, Donald J; Olivier, Annie; Pearson, Stuart E; Scott, James S; Suleman, Abid; Trigwell, Cath B; Vautier, Michel; Whittaker, Robin D; Wood, Robin.

Bioorg Med Chem Lett ; 18(2): 674-8, 2008 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-18061446

9.

Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors.

Barlaam, Bernard; Cadogan, Elaine; Campbell, Andrew; Colclough, Nicola; Dishington, Allan; Durant, Stephen; Goldberg, Kristin; Hassall, Lorraine A; Hughes, Gareth D; MacFaul, Philip A; McGuire, Thomas M; Pass, Martin; Patel, Anil; Pearson, Stuart; Petersen, Jens; Pike, Kurt G; Robb, Graeme; Stratton, Natalie; Xin, Guohong; Zhai, Baochang.

ACS Med Chem Lett ; 9(8): 809-814, 2018 Aug 09.

Artigo em Inglês | MEDLINE | ID: mdl-30128072

10.

Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.

Kettle, Jason G; Anjum, Rana; Barry, Evan; Bhavsar, Deepa; Brown, Crystal; Boyd, Scott; Campbell, Andrew; Goldberg, Kristin; Grondine, Michael; Guichard, Sylvie; Hardy, Christopher J; Hunt, Tom; Jones, Rhys D O; Li, Xiuwei; Moleva, Olga; Ogg, Derek; Overman, Ross C; Packer, Martin J; Pearson, Stuart; Schimpl, Marianne; Shao, Wenlin; Smith, Aaron; Smith, James M; Stead, Darren; Stokes, Steve; Tucker, Michael; Ye, Yang.

J Med Chem ; 61(19): 8797-8810, 2018 10 11.

Artigo em Inglês | MEDLINE | ID: mdl-30204441

11.

AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models.

Weir, Hazel M; Bradbury, Robert H; Lawson, Mandy; Rabow, Alfred A; Buttar, David; Callis, Rowena J; Curwen, Jon O; de Almeida, Camila; Ballard, Peter; Hulse, Michael; Donald, Craig S; Feron, Lyman J L; Karoutchi, Galith; MacFaul, Philip; Moss, Thomas; Norman, Richard A; Pearson, Stuart E; Tonge, Michael; Davies, Gareth; Walker, Graeme E; Wilson, Zena; Rowlinson, Rachel; Powell, Steve; Sadler, Claire; Richmond, Graham; Ladd, Brendon; Pazolli, Ermira; Mazzola, Anne Marie; D'Cruz, Celina; De Savi, Chris.

Cancer Res ; 76(11): 3307-18, 2016 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-27020862

12.

Discovery of AZD3147: a potent, selective dual inhibitor of mTORC1 and mTORC2.

Pike, Kurt G; Morris, Jeff; Ruston, Linette; Pass, Sarah L; Greenwood, Ryan; Williams, Emma J; Demeritt, Julie; Culshaw, Janet D; Gill, Kristy; Pass, Martin; Finlay, M Raymond V; Good, Catherine J; Roberts, Craig A; Currie, Gordon S; Blades, Kevin; Eden, Jonathan M; Pearson, Stuart E.

J Med Chem ; 58(5): 2326-49, 2015 Mar 12.

Artigo em Inglês | MEDLINE | ID: mdl-25643210

13.

Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist.

De Savi, Chris; Bradbury, Robert H; Rabow, Alfred A; Norman, Richard A; de Almeida, Camila; Andrews, David M; Ballard, Peter; Buttar, David; Callis, Rowena J; Currie, Gordon S; Curwen, Jon O; Davies, Chris D; Donald, Craig S; Feron, Lyman J L; Gingell, Helen; Glossop, Steven C; Hayter, Barry R; Hussain, Syeed; Karoutchi, Galith; Lamont, Scott G; MacFaul, Philip; Moss, Thomas A; Pearson, Stuart E; Tonge, Michael; Walker, Graeme E; Weir, Hazel M; Wilson, Zena.

J Med Chem ; 58(20): 8128-40, 2015 Oct 22.

Artigo em Inglês | MEDLINE | ID: mdl-26407012

14.

Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases.

Addie, Matt; Ballard, Peter; Buttar, David; Crafter, Claire; Currie, Gordon; Davies, Barry R; Debreczeni, Judit; Dry, Hannah; Dudley, Philippa; Greenwood, Ryan; Johnson, Paul D; Kettle, Jason G; Lane, Clare; Lamont, Gillian; Leach, Andrew; Luke, Richard W A; Morris, Jeff; Ogilvie, Donald; Page, Ken; Pass, Martin; Pearson, Stuart; Ruston, Linette.

J Med Chem ; 56(5): 2059-73, 2013 Mar 14.

Artigo em Inglês | MEDLINE | ID: mdl-23394218

15.

Shipshape to nurse.

Pearson, Stuart.

Nurs Stand ; 21(33): 62-3, 2007.

Artigo em Inglês | MEDLINE | ID: mdl-17494448

16.

Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation.

Ward, Richard A; Brassington, Claire; Breeze, Alexander L; Caputo, Alessandro; Critchlow, Susan; Davies, Gareth; Goodwin, Louise; Hassall, Giles; Greenwood, Ryan; Holdgate, Geoffrey A; Mrosek, Michael; Norman, Richard A; Pearson, Stuart; Tart, Jonathan; Tucker, Julie A; Vogtherr, Martin; Whittaker, David; Wingfield, Jonathan; Winter, Jon; Hudson, Kevin.

J Med Chem ; 55(7): 3285-306, 2012 Apr 12.

Artigo em Inglês | MEDLINE | ID: mdl-22417091

17.

Development of a practical Buchwald-Hartwig amine arylation protocol using a conveniently prepared (NHC)Pd(R-allyl)Cl catalyst.

Cawley, Mark J; Cloke, F Geoffrey N; Fitzmaurice, Richard J; Pearson, Stuart E; Scott, James S; Caddick, Stephen.

Org Biomol Chem ; 6(15): 2820-5, 2008 Aug 07.

Artigo em Inglês | MEDLINE | ID: mdl-18633541

18.

Neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase.

Ballard, Peter; Barlaam, Bernard C; Bradbury, Robert H; Dishington, Allan; Hennequin, Laurent F A; Hickinson, D Mark; Hollingsworth, Ian M; Kettle, Jason G; Klinowska, Teresa; Ogilvie, Donald J; Pearson, Stuart E; Scott, James S; Suleman, Abid; Whittaker, Robin; Williams, Emma J; Wood, Robin; Wright, Lindsay.

Bioorg Med Chem Lett ; 17(22): 6326-9, 2007 Nov 15.

Artigo em Inglês | MEDLINE | ID: mdl-17869514

19.

Inhibitors of epidermal growth factor receptor tyrosine kinase: optimisation of potency and in vivo pharmacokinetics.

Ballard, Peter; Bradbury, Robert H; Harris, Craig S; Hennequin, Laurent F A; Hickinson, Mark; Kettle, Jason G; Kendrew, Jane; Klinowska, Teresa; Ogilvie, Donald J; Pearson, Stuart E; Williams, Emma J; Wilson, Ingrid.

Bioorg Med Chem Lett ; 16(18): 4908-12, 2006 Sep 15.

Artigo em Inglês | MEDLINE | ID: mdl-16806916

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