Sitting with it: An investigation of the relationship between trait mindfulness and sustained attention.

BACKGROUND: Sustaining attention for extended periods of time is associated with negative affect and this increase in negative affect is related to poorer task performance. Trait mindfulness has been shown to be associated with better sustained attention performance. This may be because trait mindfulness is associated with better attention ability or better emotion regulation ability. AIMS: The present research aims to replicate previous findings and better understand why trait mindfulness is associated with better sustained attention performance. METHOD: Participants responded to self-report questionnaires assessing their trait mindfulness, attentional control, and experiential avoidance. Next, participants performed a sustained attention task, during which they also reported their subjective feelings of discomfort and boredom. Finally, participants reported their retrospective discomfort and boredom after the task. RESULTS: We replicated and extended previous findings by showing that the relationship between trait mindfulness and sustained attention performance was mediated by negative affect experienced during the task. Moreover, the correlation between trait mindfulness and sustained attention disappeared when controlling for experiential avoidance, but remined when controlling for attention control. CONCLUSION: Our results suggest that trait mindfulness is associated with sustained attention because of enhanced emotion regulation and that enhancing affective regulation would be an effective strategy for improving sustained attention performance.

Psychedelic microdosing benefits and challenges: an empirical codebook.

BACKGROUND: Microdosing psychedelics is the practice of consuming very low, sub-hallucinogenic doses of a psychedelic substance, such as lysergic acid diethylamide (LSD) or psilocybin-containing mushrooms. According to media reports, microdosing has grown in popularity, yet the scientific literature contains minimal research on this practice. There has been limited reporting on adverse events associated with microdosing, and the experiences of microdosers in community samples have not been categorized. METHODS: In the present study, we develop a codebook of microdosing benefits and challenges (MDBC) based on the qualitative reports of a real-world sample of 278 microdosers. RESULTS: We describe novel findings, both in terms of beneficial outcomes, such as improved mood (26.6%) and focus (14.8%), and in terms of challenging outcomes, such as physiological discomfort (18.0%) and increased anxiety (6.7%). We also show parallels between benefits and drawbacks and discuss the implications of these results. We probe for substance-dependent differences, finding that psilocybin-only users report the benefits of microdosing were more important than other users report. CONCLUSIONS: These mixed-methods results help summarize and frame the experiences reported by an active microdosing community as high-potential avenues for future scientific research. The MDBC taxonomy reported here informs future research, leveraging participant reports to distil the highest-potential intervention targets so research funding can be efficiently allocated. Microdosing research complements the full-dose literature as clinical treatments are developed and neuropharmacological mechanisms are sought. This framework aims to inform researchers and clinicians as experimental microdosing research begins in earnest in the years to come.

Keeping the promise: a critique of the current state of microdosing research.

Introduction: The practice of taking small, sub-hallucinogenic doses of psychedelics, known as microdosing, has exploded in popularity over the last decade. Users claim benefits ranging from improved mood and enhanced creativity to an increased sense of meaning and connectedness in life. While research on microdosing is still lagging behind the shift in public opinion, several papers have been published in the last five years which attempted to assess the effects of microdosing. Methods: This review paper aimed to critically analyze the research practices used in the recent wave of microdosing research: We reviewed 15 papers published before the closing date of this review in March 2022. Results: Our review concludes that it is premature to draw any conclusions about the efficacy or safety of microdosing since the research quality cannot be considered confirmatory. Discussion: We propose some potential causes for the current state of the literature and some suggestions for how these causes may be ameliorated.

Psychedelics and neonihilism: connectedness in a meaningless world.

The resurgence of psychedelic research explicitly targets treating mental health conditions largely through psychedelics-assisted psychotherapy. Current theories about mechanisms of change in psychedelics-assisted psychotherapy focus on mystical experiences as the main driver of symptom improvement. During these mystical experiences, participants report an enhanced sense of salience, connectedness, and meaning. Simultaneously, a growing psychedelic culture is also cultivating the use of psychedelics as medicine for relieving symptoms of anxiety and depression and promoting cognitive functions. We argue that an integral part of the excitement around the resurgence in psychedelics is in response to a meaning and alienation crisis that correlates with rising rates of anxiety and depression. Framing the absence of meaning as neonihilism, a contemporary correlate to the 19th-century phenomenon with unique features present in a neoliberal cultural context, we explore whether psychedelics combined with group therapy can provide answers to modern experiences of meaninglessness. Based on this exploration, we suggest concrete next steps both in the theory and practice of psychedelic psychotherapy toward what we are calling neonihilistic psychedelic group psychotherapy.

A perspective on psychedelic teratogenicity: the utility of zebrafish models.

Psychedelic drugs have experienced an unprecedented surge in recreational use within the past few years. Among recreational users, the risks of psychedelic use by pregnant and breastfeeding women are severely understudied and there is little information on the potential teratogenic effects of these drugs. We provide an overview of the previous data on psychedelic teratogenicity from rodent studies and human surveys, discuss their limitations, and propose the utility of the zebrafish as a potential effective model for investigating psychedelic teratogenicity. Recent years have validated the use of zebrafish in the study of fetal exposure and developmental biology; we highlight these properties of the zebrafish for its suitability in psychedelic toxicity research.

Manifest your desires: Psychedelics and the self-help industry.

A psychedelic industrial complex is emerging as new research on these substances and their effects is being approved. These substances show promise, but much remains unknown about their potential for both benefit and harm. Despite the paucity of reliable mechanistic evidence, some entrepreneurs have already begun to market psychedelic advice. We draw on some critiques of the self-help industry to propose potential parallels in the psychedelic industry. Overstated claims, cultural lore, for-profit organizations, and spiritual gurus come with the territory of both industries aimed at selling solutions for mental health disorders. We offer some guidelines for responsible research, therapy, and policy to temper these concerns, focusing on evidence-based practices, decriminalization, and rigorous therapist training.

Set and setting in microdosing: an oft-overlooked principle.

RATIONALE: The use of psychedelics for medical and recreational purposes is rising. Contextual factors such as expectancy, intention, and sensory and social environment (set and setting) are widely recognized as moderating the effects of these substances. Nevertheless, clinical trials of microdosing - the ingestion of small, sub-hallucinogenic doses of psychedelics - rarely report their set and setting. This fact suggests that such factors are not considered important in the context of microdosing. OBJECTIVE: This paper challenges this assumption and makes the case for the crucial relevance of set and setting in microdosing practice. Building on set and setting theory and placebo theory, we explain why set and setting are of crucial importance in the case of microdosing. RESULTS: This reasoning helps elucidate the role of set and setting in determining the outcomes of microdosing and helps explain some of the contradictory results that have emerged in microdosing research in recent years. CONCLUSION: Set and setting are important constructs to be considered especially in the context of microdosing psychedelics. By reporting set and setting, the results of microdosing research can be made more reliable and consistent.

Microdosing psychedelics: Subjective benefits and challenges, substance testing behavior, and the relevance of intention.

BACKGROUND: Microdosing psychedelics is the practice of taking small, sub-hallucinogenic doses of lysergic acid diethylamide or psilocybin-containing mushrooms. Despite its surging popularity, little is known about the specific intentions to start microdosing and the effects of this practice. AIMS: First, we aimed to replicate previous findings regarding the subjective benefits and challenges reported for microdosing. Second, we assessed whether people who microdose test their substances before consumption. Third, we examined whether having an approach-intention to microdosing was predictive of more reported benefits. METHODS: The Global Drug Survey runs the world's largest online drug survey. Participants who reported last year use of lysergic acid diethylamide or psilocybin in the Global Drug Survey 2019 were offered the opportunity to answer a sub-section on microdosing. RESULTS: Data from 6753 people who reported microdosing at least once in the last 12 months were used for analyses. Our results suggest a partial replication of previously reported benefits and challenges among the present sample often reporting enhanced mood, creativity, focus and sociability. Counter to our prediction, the most common challenge participants associated with microdosing was 'None'. As predicted, most participants reported not testing their substances. Counter to our hypothesis, approach-intention - microdosing to approach a desired goal - predicted less rather than more benefits. We discuss alternate frameworks that may better capture the reasons people microdose. CONCLUSION: Our results suggest the perceived benefits associated with microdosing greatly outweigh the challenges. Microdosing may have utility for a variety of uses while having minimal side effects. Double-blind, placebo-controlled experiments are required to substantiate these reports.

Social interaction context shapes emotion recognition through body language, not facial expressions.

The social context-seeing people emotionally interacting-is one of the most common contexts in which emotion perception occurs. Despite its importance, emotion perception of social interactions from a 3rd-person perspective is poorly understood. Here we investigated whether emotion recognition of fear and anger is facilitated by mere congruency (the contextual figure exhibits the same emotion as the target) or by functional relations (the contextual figure exhibits a complementary emotion to the target). Furthermore, we examined which expression channel, face or body, drives social context effects. In the 1st 2 experiments (Studies 1a and 1b), participants in an online survey platform (N = 146) or university students (N = 34), viewed interacting figures displaying fear or anger, presented either as faces, bodies, or both. Participants were instructed to categorize the target figure's emotions while the other figure served as context. Results showed that fear recognition was facilitated by an interacting angry figure more strongly than by an interacting fearful figure. Moreover, this effect occurred when participants viewed the figures' bodies (with or without the faces), but not when they viewed the figures' faces alone. A 3rd online experiment (Study 2) established that this context effect was stronger when participants (N = 464) watched the figures interacting (facing each other) than when figures were not interacting (facing away from each other), suggesting that social context influences emotion perception by revealing the interactants' relation. Our findings demonstrate that emotional perception is grounded in the broader process of social interaction and highlight the role of the body in interpersonal context effects. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

The metronome response task for measuring mind wandering: Replication attempt and extension of three studies by Seli et al.

Science requires replicable tools to measure its intended constructs. Attention research has developed tools that have been used in mind-wandering research, but mind-wandering measures often rely on response-inhibition, which introduces speed-accuracy trade-offs that may conflate errors for mind-wandering. We sought to replicate three studies that used an improved mind-wandering measure: the Metronome Response Task (MRT). In a large (N=300) multisite sample, the primary MRT finding was replicated, showing that continuous rhythmic response time variability reliably predicted self-reported mind-wandering. Our findings also show previously undetected differences between intentional and unintentional mind-wandering. While previously reported mediators (motivation) and moderators (confidence) did not replicate, additional covariates add predictive value and additional constructs (e.g., boredom, effort) demonstrate convergent validity. The MRT is useful for inducing and measuring mind-wandering and provides an especially replicable tool. The MRT's measurement of attention could support future models of the complete cycle of sustained attention.

Psychedelic Research and the Need for Transparency: Polishing Alice's Looking Glass.

Psychedelics have a checkered past, alternately venerated as sacred medicines and vilified as narcotics with no medicinal or research value. After decades of international prohibition, a growing dissatisfaction with conventional mental health care and the pioneering work of the Multidisciplinary Association for Psychedelic Science (MAPS) and others has sparked a new wave of psychedelic research. Positive media coverage and new entrepreneurial interest in this potentially lucrative market, along with their attendant conflicts of interest, have accelerated the hype. Given psychedelics' complex history, it is especially important to proceed with care, holding ourselves to a higher scientific rigor and standard of transparency. Universities and researchers face conflicting interests and perverse incentives, but we can avoid missteps by expecting rigorous and transparent methods in the growing science of psychedelics. This paper provides a pragmatic research checklist and discusses the importance of using the modern research and transparency standards of Open Science using preregistration, open materials and data, reporting constraints on generality, and encouraging replication. We discuss specific steps researchers should take to avoid another replication crisis like those devastating psychology, medicine, and other fields. We end with a discussion of researcher intention and the value of actively deciding to abide by higher scientific standards. We can build a rigorous, transparent, replicable psychedelic science by using Open Science to understand psychedelics' potential as they re-enter science and society.

Semantic and affective representations of valence: Prediction of autonomic and facial responses from feelings-focused and knowledge-focused self-reports.

The term valence can refer to either the affective response (e.g., "I feel bad") or the semantic knowledge about a stimulus (e.g., "car accidents are bad"). Accordingly, the content of self-reports can be more "experience-near" and proxy to the mental state of affective feelings, or, alternatively, involve nonexperiential semantic knowledge. In this work we compared three experimental protocol instructions: feelings-focused self-reports that encourage participants to report their feelings (but not knowledge); knowledge-focused self-reports that encourage participants to report about semantic knowledge (and not feelings); and "feelings-naïve", in which participants were asked to report their feelings but are not explicitly presented with the distinction between feelings and knowledge. We compared the ability of the three types of self-report data to predict facial electromyography, heart rate, and electrodermal changes in response to affective stimuli. The relationship between self-reports and both physiological signal intensity and signal discriminability were examined. The results showed a consistent advantage for feelings-focused over knowledge-focused instructions in prediction of physiological response with feelings-naïve instructions falling in between. The results support the theoretical distinction between affective and semantic representations of valence and the validity of feelings-focused and knowledge-focused self-report instructions. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Microdosing psychedelics: Demographics, practices, and psychiatric comorbidities.

RATIONALE: Microdosing psychedelics - the practice of consuming small, sub-hallucinogenic doses of substances such as LSD or psilocybin - is gaining attention in popular media but remains poorly characterized. Contemporary studies of psychedelic microdosing have yet to report the basic psychiatric descriptors of psychedelic microdosers. OBJECTIVES: To examine the practices and demographics of a population of psychedelic microdosers - including their psychiatric diagnoses, prescription medications, and recreational substance use patterns - to develop a foundation on which to conduct future clinical research. METHODS: Participants (n = 909; Mage = 26.9, SD = 8.6; male = 83.2%; White/European = 79.1%) recruited primarily from the online forum Reddit completed an anonymous online survey. Respondents who reported using LSD, psilocybin, or both for microdosing were grouped and compared with non-microdosing respondents using exploratory odds ratio testing on demographic variables, rates of psychiatric diagnoses, and past-year recreational substance use. RESULTS: Of microdosers, most reported using LSD (59.3%; Mdose = 13 mcg, or 11.3% of one tab) or psilocybin (25.9%; Mdose = 0.3 g of dried psilocybin mushrooms) on a one-day-on, two-days-off schedule. Compared with non-microdosers, microdosers were significantly less likely to report a history of substance use disorders (SUDs; OR = 0.17 (95% CI: 0.05-0.56)) or anxiety disorders (OR = 0.61 (95% CI: 0.41-0.91)). Microdosers were also more likely to report recent recreational substance use compared with non-microdosers (OR = 5.2 (95% CI: 2.7-10.8)). CONCLUSIONS: Well-designed randomized controlled trials are needed to evaluate the safety and tolerability of this practice in clinical populations and to test claims about potential benefits.

Microdosing psychedelics: personality, mental health, and creativity differences in microdosers.

RATIONALE: Microdosing psychedelics-the regular consumption of small amounts of psychedelic substances such as LSD or psilocybin-is a growing trend in popular culture. Recent studies on full-dose psychedelic psychotherapy reveal promising benefits for mental well-being, especially for depression and end-of-life anxiety. While full-dose therapies include perception-distorting properties, microdosing mayprovide complementary clinical benefits using lower-risk, non-hallucinogenic doses. OBJECTIVES: This pre-registered study aimed to investigate whether microdosing psychedelics is related to differences in personality, mental health, and creativity. METHODS: In this observational study, respondents recruited from online forums self-reported their microdosing behaviors and completed questionnaires concerning dysfunctional attitudes, wisdom, negative emotionality, open-mindedness, and mood. Respondents also performed the Unusual Uses Task to assess their creativity. RESULTS: Current and former microdosers scored lower on measures of dysfunctional attitudes (p < 0.001, r = - 0.92) and negative emotionality (p = 0.009, r = - 0.85) and higher on wisdom (p < 0.001, r = 0.88), openmindedness(p = 0.027, r = 0.67), and creativity (p < 0.001, r = 0.15) when compared to non-microdosing controls. CONCLUSIONS: These findings provide promising initial evidence that warrants controlled experimental research to directly test safety and clinical efficacy. As microdoses are easier to administer than full-doses, this new paradigm has the exciting potential to shape future psychedelic research.

Is fear in your head? A comparison of instructed and real-life expressions of emotion in the face and body.

The majority of emotion perception studies utilize instructed and stereotypical expressions of faces or bodies. While such stimuli are highly standardized and well-recognized, their resemblance to real-life expressions of emotion remains unknown. Here we examined facial and body expressions of fear and anger during real-life situations and compared their recognition to that of instructed expressions of the same emotions. In order to examine the source of the affective signal, expressions of emotion were presented as faces alone, bodies alone, and naturally, as faces with bodies. The results demonstrated striking deviations between recognition of instructed and real-life stimuli, which differed as a function of the emotion expressed. In real-life fearful expressions of emotion, bodies were far better recognized than faces, a pattern not found with instructed expressions of emotion. Anger reactions were better recognized from the body than from the face in both real-life and instructed stimuli. However, the real-life stimuli were overall better recognized than their instructed counterparts. These results indicate that differences between instructed and real-life expressions of emotion are prevalent and raise caution against an overreliance of researchers on instructed affective stimuli. The findings also demonstrate that in real life, facial expression perception may rely heavily on information from the contextualizing body. (PsycINFO Database Record