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Blood ; 112(12): 4401-10, 2008 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-18780835

RESUMO

HIV-1 infection is associated with B-cell abnormalities, such as hypergammaglobulinemia, poor immunization responses, and loss of serologic memory. To determine whether altered expression of chemokine receptors and their ligands may play a role in B-cell dysfunctions during HIV-1 infection, the expression of CXC chemokine receptor 4 (CXCR4), CXCR5, and CC chemokine receptor 7 (CCR7) and their respective ligands on CD19(+) B cells were examined in HIV-1-infected patients and controls. We report a decreased CXCR5 expression on B cells from patients (P < .05), a phenomenon associated with a low CD4 T-cell count (< 350 cells/microL). Interestingly, an increased expression of CXC chemokine ligand 13 (CXCL13), the ligand for CXCR5, was found in peripheral B cells from HIV-1-infected patients. Moreover, on B-cell activation in vitro, CXCL13 was secreted in culture. CXCL13(+) B cells were also found in the lymph nodes of HIV-1-infected patients, but not in control tissue. B-cell migration toward CXCL13, CXCL12, and CC chemokine ligand 21 (CCL21), ligands for CXCR5, CXCR4, and CCR7 was also evaluated. In patients with a low CD4 T-cell count, migration toward all ligands was increased. Our findings indicate that altered expression of the chemokine receptor-ligand pair, CXCR5/CXCL13, may participate in the establishment of B-cell dysfunctions during HIV-1 infection.


Assuntos
Linfócitos B/metabolismo , Quimiocina CXCL13/metabolismo , Infecções por HIV/metabolismo , HIV-1 , Receptores CXCR5/metabolismo , Adulto , Idoso , Antígenos de Superfície/genética , Antígenos de Superfície/metabolismo , Linfócitos B/patologia , Estudos de Casos e Controles , Células Cultivadas , Quimiocina CXCL13/genética , Quimiocina CXCL13/farmacologia , Feminino , Perfilação da Expressão Gênica , Regulação da Expressão Gênica/efeitos dos fármacos , Infecções por HIV/sangue , Infecções por HIV/genética , Infecções por HIV/imunologia , Humanos , Masculino , Pessoa de Meia-Idade , Análise de Sequência com Séries de Oligonucleotídeos , Receptores CXCR5/genética , Adulto Jovem
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