Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed.

Circular RNAs (circRNAs) are an endogenous class of animal RNAs. Despite their abundance, their function and expression in the nervous system are unknown. Therefore, we sequenced RNA from different brain regions, primary neurons, isolated synapses, as well as during neuronal differentiation. Using these and other available data, we discovered and analyzed thousands of neuronal human and mouse circRNAs. circRNAs were extraordinarily enriched in the mammalian brain, well conserved in sequence, often expressed as circRNAs in both human and mouse, and sometimes even detected in Drosophila brains. circRNAs were overall upregulated during neuronal differentiation, highly enriched in synapses, and often differentially expressed compared to their mRNA isoforms. circRNA expression correlated negatively with expression of the RNA-editing enzyme ADAR1. Knockdown of ADAR1 induced elevated circRNA expression. Together, we provide a circRNA brain expression atlas and evidence for important circRNA functions and values as biomarkers.

Optimal Control of Uniformly Heated Granular Fluids in Linear Response.

We present a detailed analytical investigation of the optimal control of uniformly heated granular gases in the linear regime. The intensity of the stochastic driving is therefore assumed to be bounded between two values that are close, which limits the possible values of the granular temperature to a correspondingly small interval. Specifically, we are interested in minimising the connection time between the non-equilibrium steady states (NESSs) for two different values of the granular temperature by controlling the time dependence of the driving intensity. The closeness of the initial and target NESSs make it possible to linearise the evolution equations and rigorously-from a mathematical point of view-prove that the optimal controls are of bang-bang type, with only one switching in the first Sonine approximation. We also look into the dependence of the optimal connection time on the bounds of the driving intensity. Moreover, the limits of validity of the linear regime are investigated.

Selective heterogeneous hydrodeoxygenation of acetophenone over monometallic and bimetallic Pt-Co catalyst.

The hydrodeoxygenation (HDO) of acetophenone was evaluated in liquid phase and gas phase over monometallic Pt/SiO2, Co/SiO2 and bimetallic Pt-Co/SiO2 catalysts. The influence of reaction time and loading of the catalyst were analysed by following the conversion and products selectivity. Phenylethanol, cyclohexylethanone and cyclohexylethanol are the main products of reaction using the Pt/SiO2 catalyst. By contrast, ethylbenzene and phenylethanol are the only products formed on the Co/SiO2 and Pt-Co/SiO2 catalysts. The bimetallic catalyst is more stable as a function of time and more active towards the HDO process than the monometallic systems. The presence of an organic solvent showed only minor changes in product yields with no effect on the product speciation. Periodic density functional theory analysis indicates a stronger interaction between the carbonyl group of acetophenone with Co than with Pt sites of the mono and bimetallic systems, indicating a key activity of oxophilic sites towards improved selectivity to deoxygenated products. This article is part of the theme issue 'Bio-derived and bioinspired sustainable advanced materials for emerging technologies (part 2)'.

Spin-orbit effects on magnetically induced current densities in the M5- (M = N,P,As,Sb,Bi,Mc) clusters.

This study reports the spin-orbit effects on the aromaticity of the N5-, P5-, As5-, Sb5-, Bi5-, and Mc5- anionic clusters via the magnetically induced current-density method. All-electron density functional theory (DFT) calculations were carried out using the four-component Dirac-Coulomb (DC) hamiltonian, including scalar and spin-orbit relativistic effects. The magnetic index of aromaticity was calculated by numerical integration over the current flow between two atoms in the pentagonal ring. These values were compared to the spin-free values (spin-orbit coupling switched off), in order to assess the spin-orbit effect on aromaticity. It was found that in the heavy anions, Bi5- and Mc5-, there is a significant influence of the spin-orbit coupling. © 2018 Wiley Periodicals, Inc.

Reversible behavioral phenotypes in a conditional mouse model of TDP-43 proteinopathies.

Transactive response DNA-binding protein 43 (TDP-43) mislocalization and aggregation are hallmark features of amyotrophic lateral sclerosis and frontotemporal dementia (FTD). We have previously shown in mice that inducible overexpression of a cytoplasmically localized form of TDP-43 (TDP-43-ΔNLS) in forebrain neurons evokes neuropathological changes that recapitulate several features of TDP-43 proteinopathies. Detailed behavioral phenotyping could provide further validation for its usage as a model for FTD. In the present study, we performed a battery of behavioral tests to evaluate motor, cognitive, and social phenotypes in this model. We found that transgene (Tg) induction by doxycycline removal at weaning led to motor abnormalities including hyperlocomotion in the open field test, impaired coordination and balance in the rotarod test, and increased spasticity as shown by a clasping phenotype. Cognitive assessment demonstrated impaired recognition and spatial memory, measured by novel object recognition and Y-maze tests. Remarkably, TDP-43-ΔNLS mice displayed deficits in social behavior, mimicking a key aspect of FTD. To determine whether these symptoms were reversible, we suppressed Tg expression for 14 d in 1.5-month-old mice showing an established behavioral phenotype but modest neurodegeneration and found that motor and cognitive deficits were ameliorated; however, social performance remained altered. When Tg expression was suppressed in 6.5-month-old mice showing overt neurodegeneration, motor deficits were irreversible. These results indicate that TDP-43-ΔNLS mice display several core behavioral features of FTD with motor neuron disease, possibly due to functional changes in surviving neurons, and might serve as a valuable tool to unveil the underlying mechanisms of this and other TDP-43 proteinopathies.

A brain-enriched circular RNA controls excitatory neurotransmission and restricts sensitivity to aversive stimuli.

Circular RNAs (circRNAs) are a large class of noncoding RNAs. Despite the identification of thousands of circular transcripts, the biological significance of most of them remains unexplored, partly because of the lack of effective methods for generating loss-of-function animal models. In this study, we focused on circTulp4, an abundant circRNA derived from the Tulp4 gene that is enriched in the brain and synaptic compartments. By creating a circTulp4-deficient mouse model, in which we mutated the splice acceptor site responsible for generating circTulp4 without affecting the linear mRNA or protein levels, we were able to conduct a comprehensive phenotypic analysis. Our results demonstrate that circTulp4 is critical in regulating neuronal and brain physiology, modulating the strength of excitatory neurotransmission and sensitivity to aversive stimuli. This study provides evidence that circRNAs can regulate biologically relevant functions in neurons, with modulatory effects at multiple levels of the phenotype, establishing a proof of principle for the regulatory role of circRNAs in neural processes.

Information in feedback ratchets.

Feedback control uses the state information of the system to actuate on it. The information used implies an effective entropy reduction of the controlled system, potentially increasing its performance. How to compute this entropy reduction has been formally shown for a general system and has been explicitly computed for spatially discrete systems. Here, we address a relevant example of how to compute the entropy reduction by information in a spatially continuous feedback-controlled system. Specifically, we consider a feedback flashing ratchet, which constitutes a paradigmatic example for the role of information and feedback in the dynamics and thermodynamics of transport induced by the rectification of Brownian motion. A Brownian particle moves in a periodic potential that is switched on and off by a controller. The controller measures the position of the particle at regular intervals and performs the switching depending on the result of the measurement. This system reaches a long-time dynamical regime with a nonzero mean particle velocity, even for a symmetric potential. Here, we calculate the efficiency at maximum power in this long-time regime, computing all the required contributions. We show how the entropy reduction can be evaluated from the entropy of the non-Markovian sequence of control actions, and we also discuss the required sampling effort for its accurate computation. Moreover, the output power developed by the particle against an external force is investigated, which-for some values of the system parameters-is shown to become larger than the input power provided by the switching of the potential. The apparent efficiency of the ratchet thus becomes higher than one, if the entropy reduction contribution is not considered. This result highlights the relevance of including the entropy reduction by information in the thermodynamic balance of feedback-controlled devices, specifically when writing the second principle. The inclusion of the entropy reduction by information leads to a well-behaved efficiency over all the range of parameters investigated.

Oral Health and Oral Health Service Utilization in Native and Immigrant Population: A Cross-Sectional Analysis from the PELFI Cohort in Spain.

This study analyzes associated factors to self-perceived oral health and use of oral health services in native and immigrant adults from the PELFI cohort in Spain. A cross-sectional analysis was conducted (401 adults ≥ 18 years, from Spain, Ecuador, Colombia and Morocco). Frequencies for sociodemographic, self-perceived general and oral health variables were calculated. The association between oral health/oral health services use and origin country was estimated by logistic regression (adjusted odds ratio-aOR-; 95% confidence intervals -95%CI-). Ecuadorian men were more likely to report dental caries (aPR 2.75; 95%CI 1.30-5.80) and Moroccan women were more likely to report gingival bleeding (aPR 3.61; 95%CI 1.83-7.15) and the use of oral health services ≥ 1 year/never (aPR 1.69; 95%CI 1.06-2.69). Colombian women were less likely to report missing teeth (aPR 0.73; 95%CI 0.56-0.95). Poor self-perceived oral health indicators were observed in immigrants and were modified for sociodemographic and general health variables.

Factors associated to quality of life of orthodontists graduated from a public university (1993-2016): A mixed-methods approach.

INTRODUCTION: For dental professionals, including orthodontists, Quality of life (QOL) is a topic of growing concern and could be determined by objective and subjective complex factors. OBJECTIVE: This study analyzed the factors that influence the QOL of orthodontists graduated between 1993 and 2016 of a public university (Medellín, Colombia). METHODS: A mixed-methods study was conducted (cross-sectional survey; 88 participants; 3 focus groups, 21 participants). Quantitative analysis: the research included sociodemographic, labor and health characteristics as independent variables and the WHOQOL-BREF questionnaire as main outcome for QOL. Frequencies were calculated and the association between QOL and independent variables was estimated by bivariate analysis (Chi square tests) and a linear multivariate regression. Qualitative analysis: Narrative content analysis according to thematic categories. Mixed methods: a conceptual framework for QOL using the triangulation was developed. RESULTS: All the scores surpassed 55 points on the 4 domains of WHOQOL-BREF. A lower value was found in the physical dimension (57.1±10.7) and a greater value in the psychological dimension (70.8±8.3). The variables associated positively to QOL were permanent contract, teaching/research activities, monthly income, resting days per week and sex. Factors associated negatively were low social support, mental health and rent housing. Discourses of participants allowed to identify the concept of QOL and the contextual and social determinants and satisfiers. CONCLUSION: QOL of orthodontists is influenced by sociodemographic, employment, working and health factors. Therefore, QOL is a multidimensional concept that recognizes the political and socio-economic context and personal and professional experiences.

Thermochemistry and kinetic analysis for the conversion of furfural to valuable added products.

Furfural is a valuable oxygenated compound derived from the thermal decomposition of biomass, and is one of the major problems of bio-oil upgrading. Due to its high reactivity, this compound requires further upgrading to more stable products such as furfuryl alcohol, 2-methylfuran (MF), furan, 2-methyltetrahydrofuran, and tetrahydrofuran. The thermochemical data and kinetic analysis of the reactions involved in the conversion of furfural were investigated by molecular modeling to guide experimental investigations in the process of designing efficient catalysts that allows the control of the reaction pathways in specific directions, towards the production of fuel precursors or chemicals. All calculations for reactants, intermediates, and products were performed using the long range corrected functional WB97XD, with the basis set 6-311+g(d,p), under the density functional theory framework. Thermochemistry results suggest that furfural hydrogenation to form furfuryl alcohol is spontaneous up to a temperature of 523 K, but beyond this temperature the reaction becomes a nonspontaneous process. By contrast, the decarbonylation of furfural was thermodynamically favored at temperatures greater than 523 K. Therefore, furan is a thermodynamically favored product, while furfuryl alcohol is kinetically preferred. Once furfuryl alcohol is formed, the hydrogenolysis path to produce methylfuran is favored kinetically and thermodynamically, compared to the ring-hydrogenation towards tetrahydrofurfuryl alcohol. Gas phase thermodynamic properties and rate constants of the reactions involved in the conversion of furfural were calculated and compared against existing experimental data. This study provides the basis for further vapor phase catalytic studies required for upgrading of furans/furfurals to value-added chemicals. Graphical abstract Furan is a thermodynamically favored product, while furfuryl alcohol is kinetically preferred.

Oral Health-Related Quality of Life in Native and Immigrant Populations in the PELFI Study in Spain.

Quality of life and its relationship to oral health is an important consideration in the determinants of health of vulnerable groups. The aim of this study is to assess oral health-related quality of life (OHRQoL) and its related factors in native and immigrant population families from the Platform of Longitudinal Studies on Immigrant Families (PELFI) study in Spain. A cross-sectional study was conducted in a sample of 401 adults aged 18 years and older from Spain, Ecuador, Colombia, and Morocco. The OHIP-14 instrument was applied, and three summary variables were used (prevalence, extent, and severity). Sociodemographic and self-perceived health variables were included. Bivariate analyzes were carried out to summarize the variables of the OHIP-14 according to sociodemographic and health variables, and bivariate analyzes of the OHIP-14 dimensions was conducted by country of origin. Multivariate linear models were used to investigate predictors for the dimensions of the OHIP-14. Multivariate logistic models were used to estimate the association of OHRQoL with immigration status using crude and adjusted odds ratios with 95% confidence intervals (OR-95% CI). It was found that 14.8% of men and 23.8% of women reported negative impacts in terms of OHRQoL (statistically significant differences: p < 0.05). There were statistically significant differences according to the country of origin in the prevalence and severity outcomes of the OHIP-14 in women (p < 0.05), and severe outcomes were observed in Moroccan women. In women, statistically significant differences (p < 0.05) in OHRQoL were observed according to age and marital status. There were some differences between OHIP-14 summary outcomes according to the health variables. Some sociodemographic and health variables were predictors for the OHIP-14 and their dimensions with differences by sex. Multivariate analysis showed a statistically significant association between OHRQoL and immigration status for Moroccan women. Differences in OHRQoL were found according to sociodemographic and health variables. Further research could clarify the predictors of OHRQoL through epidemiological surveillance and longitudinal studies.

Comparing Oral Health Services Use in the Spanish and Immigrant Working Population.

We aim to analyze oral health services use and related factors in the immigrant working population compared to the Spanish counterparts. Cross-sectional study of working population (n = 8591) that responded Spanish National Health Survey (SNHS), 2011-2012. The association between oral health services use and migration status was estimated using logistic regression. Immigrant men presented a greater probability of oral health service use a year or more prior (aOR 1.63; 95% CI 1.26-2.02), independently of oral health, sociodemographic and socioeconomic characteristics. In immigrant women, greater probability of use of oral health services one year or more prior disappeared after adjusting for the same variables (aOR 1.15; 95% CI 0.91-1.45). Occupational social class and education level could explain better a high percentage of oral health service use one year or more prior in immigrant women but there is a persistent inequality in oral health service use in immigrant men.

Factors associated to quality of life of orthodontists graduated from a public university (1993-2016): A mixed-methods approach

ABSTRACT Introduction: For dental professionals, including orthodontists, Quality of life (QOL) is a topic of growing concern and could be determined by objective and subjective complex factors. Objective: This study analyzed the factors that influence the QOL of orthodontists graduated between 1993 and 2016 of a public university (Medellín, Colombia). Methods: A mixed-methods study was conducted (cross-sectional survey; 88 participants; 3 focus groups, 21 participants). Quantitative analysis: the research included sociodemographic, labor and health characteristics as independent variables and the WHOQOL-BREF questionnaire as main outcome for QOL. Frequencies were calculated and the association between QOL and independent variables was estimated by bivariate analysis (Chi square tests) and a linear multivariate regression. Qualitative analysis: Narrative content analysis according to thematic categories. Mixed methods: a conceptual framework for QOL using the triangulation was developed. Results: All the scores surpassed 55 points on the 4 domains of WHOQOL-BREF. A lower value was found in the physical dimension (57.1±10.7) and a greater value in the psychological dimension (70.8±8.3). The variables associated positively to QOL were permanent contract, teaching/research activities, monthly income, resting days per week and sex. Factors associated negatively were low social support, mental health and rent housing. Discourses of participants allowed to identify the concept of QOL and the contextual and social determinants and satisfiers. Conclusion: QOL of orthodontists is influenced by sociodemographic, employment, working and health factors. Therefore, QOL is a multidimensional concept that recognizes the political and socio-economic context and personal and professional experiences.

RESUMO Introdução: Entre os profissionais da área odontológica, incluindo os ortodontistas, a Qualidade de Vida (QOL) é um tópico de interesse crescente, podendo ser determinada por meio de complexos fatores objetivos e subjetivos. Objetivo: O presente estudo analisou fatores que influenciam a QOL dos ortodontistas graduados entre 1993 e 2016 em uma universidade pública (Medelín, Colômbia). Método: Foi conduzido um estudo de metodologia mista (pesquisa transversal; 88 participantes; 3 grupos focais, 21 participantes). Análise quantitativa: foram incluídas características sociodemográficas, ocupacionais e de saúde como variáveis independentes e o questionário WHOQOL-BREF como resultado principal para QOL. As frequências foram calculadas e a associação entre QOL e as variáveis independentes foram estimadas por uma análise bivariada (teste qui-quadrado) e uma regressão linear multivariada. Análise qualitativa: análise do conteúdo narrativo de acordo com as categorias temáticas. Metodologia mista: foi desenvolvida uma estrutura conceitual para QOL utilizando a triangulação. Resultados: Todas as pontuações ultrapassaram 55 pontos nos 4 domínios do WHOQOL-BREF. Um valor mais baixo foi encontrado na dimensão física (57,1±10,7) e um valor mais alto, na dimensão psicológica (70,8±8,3). As variáveis associadas positivamente à QOL foram as seguintes: contrato permanente, atividades ensino/pesquisa, renda mensal, dias de descanso por semana e sexo. Os fatores associados negativamente foram baixo suporte social, saúde mental e morar de aluguel. O discurso dos participantes permitiu a identificação do conceito de QOL, dos determinantes contextuais e sociais, e os fatores motivacionais. Conclusão: A QOL dos ortodontistas é influenciada por fatores sociodemográficos, ocupacionais, ligados ao trabalho e à saúde. Dessa maneira, a QOL se apresenta como um conceito multidimensional, que reconhece o contexto político e socioeconômico, assim como as experiências pessoais e profissionais.

Behavioral phenotyping of Nestin-Cre mice: implications for genetic mouse models of psychiatric disorders.

Genetic mouse models based on the Cre-loxP system have been extensively used to explore the influence of specific gene deletions on different aspects of behavioral neurobiology. However, the interpretation of the effects attributed to the gene deletion might be obscured by potential side effects secondary to the Cre recombinase transgene insertion or Cre activity, usually neither controlled nor reported. Here, we performed a comprehensive behavioral analysis of endophenotypes of neuropsychiatric disorders in the extensively used Nestin(Cre) mouse line, commonly employed to restrict genetic modifications to the CNS. We observed no alterations in locomotion, general exploratory activity, learning and memory, sociability, startle response and sensorimotor gating. Although the overall response to stimuli triggering anxiety-like behaviors remained unaltered in Nestin(Cre) mice, a strong impairment in the acquisition of both contextual- and cued-conditioned fear was observed. These results underline the importance of adequately controlling the behavioral performance of the employed Cre-lines per-se in pre-clinical neurobehavioral research.

[Periodontal condition and tooth loss in diabetic patients]. / Condición periodontal y pérdida dental en pacientes diabéticos del Hospital Universitario San Vicente de Paúl.

INTRODUCTION: Diabetes is a systemic disease which affects the metabolism of glucose,and it has been associated with the development of periodontal disease. OBJECTIVE: The periodontal condition and tooth loss was evaluated in diabetic subjects. MATERIALS AND METHODS: At the San Vicente de Paúl Hospital (Medellín, Colombia), 117 subjects with type 1 and 2 diabetes mellitus were examined. Patients underwent a comprehensive periodontal evaluation, glycosylated hemoglobin analysis, oral hygiene habits and history of diabetes. A descriptive and comparative analysis between the clinical parameters, tooth loss and type of diabetes was performed. RESULTS: The prevalence of gingivitis was 27.4% and periodontitis 72.6%. The most frequent systemic complication was hypertension (51.3%). The most frequently lost teeth were molars and in general, the subjects had lost an average of 7 teeth and had a poor plaque control (55.4%). No differences were seen in clinical parameters between type 1 and 2 diabetes patients. The mean probing depth was 2.6 mm. The first and second upper and lower molars showed the highest values of PD. The mean clinical attachment loss was 3.3 mm . Maxillary teeth 17, 16, and mandibular 37, 47 showed the highest values of clinical attachment loss. CONCLUSIONS: In conclusion, the periodontal condition in diabetic patients was poor, presenting periodontitis in most cases. This can be a major cause of tooth loss in diabetic subjects and requires special attention by clinicians.

Caries dental y necesidades de tratamiento en los escolares de 12 años de las instituciones oficiales del municipio de Rionegro (Antioquia, Colombia), 2010 / Dental caries and treatment needs in 12-year-old schoolchildren from public institutions of the municipality of Rionegro (Antioquia, Colombia), 2010

Introducción: el análisis de la situación de caries dental en la población de 12 años permite comprobar el cumplimiento de las metas relacionadas con el componente bucal de la salud. El objetivo de este estudio es describir la experiencia y prevalencia de cariesdental y las necesidades de tratamiento en una muestra de escolares de doce años del municipio de Rionegro. Métodos: estudio descriptivotransversal en 808 escolares de 12 años de instituciones educativas públicas del municipio de Rionegro. Se aplicaron criterios del índice de dientes cariados, obturados y perdidos tradicionales y modificados (COPDT-COPDM), y el índice de caries significativo (SiC), y se describieron según sexo, escolaridad, zona de residencia y afiliación a la seguridad social. Resultados: el COPDT en la población fue de 1,70 (± 1,63) y el COPDM de 2,19 (± 1,92). La prevalencia de caries en lesiones cavitacionales fue del 59,9% y para todas las lesiones fue de 70,8%. La experiencia de caries para el COPDT fue del 69,9 y del 77,8% para el COPDM. El SiC tomado a partir del COPDT fue de3,60 y de 4,42 a partir del COPDM. Se presentaron diferencias significativas en la experiencia, prevalencia y necesidades de tratamientoprincipalmente de acuerdo con el sexo y el grado de escolaridad. Conclusión: aunque los indicadores muestran el cumplimiento de las metas propuestas por la OMS y según estudios nacionales, se encuentran algunas situaciones de desigualdad que deben ser tenidas en cuenta para la planificación de estrategias de promoción, prevención y atención para esta población.

Introduction: analyzing dental caries conditions of 12-year-old population allows verifying how much of the oralhealth related goals have been achieved. The objective of this study was to describe the experience and prevalence of dental caries andtreatment needs of 12-year-old school children in the municipality of Rionegro. Methods: this was a cross-sectional descriptive study on 808 schoolchildren aged 12 years from public schools of the municipality of Rionegro. Both traditional (T) and modified (M) decayed, missing and filled teeth indexes (DMFTT and DMFTM) were used, as well as the Significant Caries Index (SiC). The obtained data wereanalyzed according to gender, education level, place of residence, and health insurance status. Results: the DMFTT value among the studied population was 1.70 (± 1.63) and the DMFTM was 2.19 (± 1.92). The prevalence of cavitated caries lesions was 59.9%, and for all the lesions it was 70.8%. Caries experience for the DMFTT was 69.9%, and 77.8% in the case of DMFTM. The SiC measured according to the DMFTT was 3.60, and 4.42 for DMFTM. Significant differences were observed in terms of experience, prevalence andtreatment needs, especially in relation to gender and school grade. Conclusions: these values indicate accomplishment of the goals set by the WHO and by Colombian standards. Nevertheless, they also reveal some inequalities that must be considered when planning promotion, prevention and attention programs aimed at this population.

Condición periodontal y pérdida dental en pacientes diabéticos del Hospital Universitario San Vicente de Paúl / Periodontal condition and tooth loss in diabetic patients

Introducción. La diabetes es una enfermedad sistémica que afecta el metabolismo de la glucosa y se ha relacionado con el desarrollo de enfermedad periodontal. Objetivo. El objetivo de este estudio fue determinar la condición periodontal y la pérdida dental de un grupo de pacientes diabéticos del Hospital Universitario San Vicente de Paúl. Materiales y métodos. A 117 sujetos con diabetes de tipo 1 y 2 se les practicó un examen periodontal completo, determinación de valores de la hemoglobina A1C (glycosilated hemoglobin) y radiografías periapicales, y se les indagó sobre hábitos de higiene oral e historia de diabetes. Los datos se analizaron de forma descriptiva y comparativa entre los parámetros clínicos, pérdida dental y tipo de diabetes. Resultados. La prevalencia de gingivitis fue de 27,4 % y la de periodontitis de 72,6 %. La complicación sistémica más frecuente fue la hipertensión arterial (51,3 %). Los dientes más frecuentemente perdidos fueron los molares y, en promedio, los sujetos habían perdido siete dientes. El control de placa bacteriana fue pobre (55,4 %). No hubo diferencias en los parámetros clínicos entre pacientes diabéticos de tipo 1 y de tipo 2. El promedio de profundidad con sonda fue 2,62 mm, siendo los molares los dientes más afectados. El promedio de pérdida de inserción fue de 3,03 mm. Los dientes 17, 16, 27, 37 y 47 presentaron los valores más altos de pérdida de inserción. Conclusiones. En conclusión, la condición periodontal en pacientes diabéticos fue mala, y presentaban periodontitis en la mayoría de los casos. Esto puede ser una causa importante de pérdida dental en sujetos diabéticos y requiere de especial atención por parte de los odontólogos y médicos.

Introduction. Diabetes is a systemic disease which affects the metabolism of glucose,and it has been associated with the development of periodontal disease. Objective. The periodontal condition and tooth loss was evaluated in diabetic subjects. Materials and methods. At the San Vicente de Paúl Hospital (Medellín, Colombia), 117 subjects with type 1 and 2 diabetes mellitus were examined. Patients underwent a comprehensive periodontal evaluation, glycosylated hemoglobin analysis, oral hygiene habits and history of diabetes. A descriptive and comparative analysis between the clinical parameters, tooth loss and type of diabetes was performed. Results. The prevalence of gingivitis was 27.4% and periodontitis 72.6%. The most frequent systemic complication was hypertension (51.3%). The most frequently lost teeth were molars and in general, the subjects had lost an average of 7 teeth and had a poor plaque control (55.4%). No differences were seen in clinical parameters between type 1 and 2 diabetes patients. The mean probing depth was 2.6 mm. The first and second upper and lower molars showed the highest values of PD. The mean clinical attachment loss was 3.3 mm . Maxillary teeth 17, 16, and mandibular 37, 47 showed the highest values of clinical attachment loss. Conclusions. In conclusion, the periodontal condition in diabetic patients was poor, presenting periodontitis in most cases. This can be a major cause of tooth loss in diabetic subjects and requires special attention by clinicians.

Caries dental y necesidades de tratamiento en el primer molar permanente en escolares de 12 años de las escuelas públicas del municipio de Rionegro (Antioquia, Colombia), 2010 / Dental Caries and Treatment Needs in the First P ermanent Mol ar in 12-year-old School children fr om P ublic Schools in the Municipal ity of Rionegro (Antioquia, Colombia), 2010

Antecedentes: es importante evaluar el primer molar permanente, ya que en edad escolares el diente permanente más afectado por caries. La prevalencia de caries en estos dientesse ha asociado con la actividad futura de caries. Objetivo: determinar la prevalencia decaries y las necesidades de tratamiento de los primeros molares permanentes en la poblaciónescolar de 12 años de las escuelas oficiales del municipio de Rionegro (Antioquia).Métodos: se realizó un estudio descriptivo transversal en 808 escolares de 12 años deescuelas públicas del municipio. Se analizó la prevalencia de caries dental en el primer molarpermanente por número y tipo de dientes afectados y de acuerdo con sexo, escolaridad,zona de residencia y afiliación al Sistema General de Seguridad Social en Salud (SGSSS).También se describieron las necesidades de tratamiento para cada primer molar permanente.Resultados: los molares inferiores presentaron la mayor prevalencia de cariesdental en relación con las variables de afiliación al SGSSS, sexo y zona de residencia;en estas dos últimas variables se evidenció más afectación en el primer molar inferiorderecho y concentración en este molar de las necesidades de tratamiento restaurativo.Conclusiones: aunque se cuenta con estudios previos sobre prevalencia de caries dentalen el municipio que muestran cumplimiento de metas de la Organización Mundial de laSalud, son más escasos los estudios que evalúen de manera individual los primeros molarespermanentes para orientar políticas de salud pública dirigidos a la preservación de estasimportantes estructuras dentales...

Background: Evaluation of the first permanent molar is important since it is the tooth thatis most affected from dental cavities in schoolers. Caries prevalence of this molar has beenassociated with future caries activity. Objective: Determine caries prevalence and treatmentneeds in the first permanent molar of a 12-year-old population from public schools in themunicipality of Rionegro (Antioquia). Methods: A descriptive study in 808 12-year-old schoolchildren from public schools in Rionegro was conducted. Caries prevalence in the first permanentmolar was analyzed regarding number and type of teeth affected and associationwith sex, grade, zone of residence, and type of affiliation to the social security system (SSS).Needs for dental treatment in this molar were also described. Results: Lower molars werethe most affected by dental caries in relationship with sex, SSS, and zone of residence; in thelatter two dental cavities were more prevalent in the right lower first molar, tooth in which theneed for restorative treatment is higher than the other first molars. Conclusions: Althoughthere are previous studies on the dental health status in Rionegro and indicators show thatthe goals of the World Health Organization are being met, evaluative research focused onthe first permanent molar is scarce and necessary given its importance for health publicpolicymaking intended to preserve this teeth...