Detalhe da pesquisa
1.
C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma.
Nature
; 506(7489): 451-5, 2014 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24553141
2.
Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas.
Acta Neuropathol
; 136(2): 211-226, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29909548
3.
Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology.
Acta Neuropathol
; 131(6): 833-45, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26810070
4.
Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication.
J Biol Chem
; 287(17): 14289-300, 2012 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22383522
5.
Small molecule inhibitors of PCNA/PIP-box interaction suppress translesion DNA synthesis.
Bioorg Med Chem
; 21(7): 1972-7, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23395113
6.
Functional regulation of cystic fibrosis transmembrane conductance regulator-containing macromolecular complexes: a small-molecule inhibitor approach.
Biochem J
; 435(2): 451-62, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21299497
7.
Amide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathway.
Bioorg Med Chem
; 18(13): 4801-11, 2010 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20605720
8.
Structure of the Hybrid-2 type intramolecular human telomeric G-quadruplex in K+ solution: insights into structure polymorphism of the human telomeric sequence.
Nucleic Acids Res
; 35(15): 4927-40, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17626043
9.
Structure of the intramolecular human telomeric G-quadruplex in potassium solution: a novel adenine triple formation.
Nucleic Acids Res
; 35(7): 2440-50, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17395643
10.
Evaluation of a chemical library of small-molecule Dishevelled antagonists that suppress tumor growth by down-regulating T-cell factor-mediated transcription.
Mol Cancer Ther
; 7(6): 1633-8, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18566234
11.
Indole-2-amide based biochemical antagonist of Dishevelled PDZ domain interaction down-regulates Dishevelled-driven Tcf transcriptional activity.
Bioorg Med Chem Lett
; 18(3): 946-9, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18180158
12.
XR5944: A potent inhibitor of estrogen receptors.
Mol Cancer Ther
; 6(1): 213-9, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17218634
13.
Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups.
Cancer Cell
; 27(5): 728-43, 2015 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25965575
14.
Posterior fossa and spinal gangliogliomas form two distinct clinicopathologic and molecular subgroups.
Acta Neuropathol Commun
; 2: 18, 2014 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24529209
15.
Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas.
Nat Genet
; 45(6): 602-12, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23583981
16.
A structure-activity relationship study of small-molecule inhibitors of GLI1-mediated transcription.
Biopolymers
; 95(1): 24-30, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20872873
17.
DNA sequence selectivity of human topoisomerase I-mediated DNA cleavage induced by camptothecin.
Protein Sci
; 18(6): 1326-31, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19472416
18.
Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins.
Protein Sci
; 18(5): 994-1002, 2009 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19388021
19.
Structure-activity relationships and cancer-cell selective toxicity of novel inhibitors of glioma-associated oncogene homologue 1 (Gli1) mediated transcription.
J Med Chem
; 52(14): 4277-87, 2009 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-19545120
20.
Human topoisomerase I C-terminal domain fragment containing the active site tyrosine is a molten globule: implication for the formation of competent productive complex.
J Struct Biol
; 159(1): 111-21, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17434318