RESUMO
Injection of sodium urate or calcium pyrophosphate crystals into the stifle joints of anesthetized dogs almost invariably induced an acute exudative response. This response was quantified by serial measurements of intra-articular pressure, pH and leukocyte concentration. Pressure rose progressively and reflected intra-articular volume increase. The hydrogen ion concentration increased as the reaction progressed and correlated in a given exudate with the leukocyte concentration. Analysis of sequential physiologic and biochemical changes occurring in this model of crystal-induced inflammation may provide insight into the mechanisms of acute gouty arthritis in man.
Assuntos
Artrite , Fosfatos de Cálcio , Difosfatos , Sinovite , Ácido Úrico , Animais , Cães , Injeções Intra-ArticularesAssuntos
Lesões Encefálicas/induzido quimicamente , Serotonina/farmacologia , Animais , Edema Encefálico/induzido quimicamente , Tronco Encefálico/efeitos dos fármacos , Tronco Encefálico/fisiopatologia , Gatos , Coma/induzido quimicamente , Lateralidade Funcional/efeitos dos fármacos , Manifestações NeurológicasRESUMO
Anesthetized adult female rhesus monkeys were impacted in the middle of the sternum with a 10 kg stunner traveling at a speed of 22-25 mph to simulate an automobile accident. Blodd was obtained at 10 and 60 min following the impact, and approximately 50 values were measured with an autoanalyzer. Blunt chest shock and trauma produced a biochemical, hematologic, and urinary profile which might be used to aid life saving measures.