Detalhe da pesquisa
1.
Discovery of α-Ketoamide inhibitors of SARS-CoV-2 main protease derived from quaternized P1 groups.
Bioorg Chem
; 143: 107001, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38101266
2.
Discovery of benzodiazepine derivatives as a new class of covalent inhibitors of SARS-CoV-2 main protease.
Bioorg Med Chem Lett
; 92: 129407, 2023 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37437852
3.
Discovery of 3-phenyl-1,2,4-oxadiazole derivatives as a new class of SARS-CoV-2 main protease inhibitors.
Bioorg Med Chem Lett
; 86: 129238, 2023 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36924946
4.
Discovery of 6,7-dihydro-5H-pyrrolo[3,4-d] pyrimidine derivatives as a new class of ATR inhibitors.
Bioorg Med Chem Lett
; 63: 128651, 2022 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35245663
5.
Discovery of 1,8-disubstituted-[1,2,3]triazolo[4,5-c]quinoline derivatives as a new class of Hippo signaling pathway inhibitors.
Bioorg Med Chem Lett
; 29(18): 2595-2603, 2019 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31400941
6.
Analysis of TTSuV1b antibody in porcine serum and its correlation with four antibodies against common viral infectious diseases.
Virol J
; 12: 125, 2015 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26260234
7.
Identification of a new class of activators of the Hippo pathway with antitumor activity in vitro and in vivo.
Biochem Pharmacol
; 224: 116217, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38641306
8.
Discovery of [1,2,3]Triazolo[4,5-c]quinoline Derivatives as a New Class of Ataxia-Telangiectasia Mutated Kinase Inhibitors.
ACS Med Chem Lett
; 14(6): 746-756, 2023 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37312863
9.
Discovery and structure-activity relationship studies of novel α-ketoamide derivatives targeting the SARS-CoV-2 main protease.
Eur J Med Chem
; 259: 115657, 2023 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37517202
10.
A new generation Mpro inhibitor with potent activity against SARS-CoV-2 Omicron variants.
Signal Transduct Target Ther
; 8(1): 128, 2023 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36928316
11.
An orally available Mpro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron.
Nat Microbiol
; 7(5): 716-725, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35477751
12.
SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model.
Science
; 371(6536): 1374-1378, 2021 03 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33602867
13.
Discovery of Potent Small-Molecule SIRT6 Activators: Structure-Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity.
J Med Chem
; 63(18): 10474-10495, 2020 09 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32787077
14.
Antimicrobial peptide DP7 with potential activity against SARS coronavirus infections.
Signal Transduct Target Ther
; 6(1): 140, 2021 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33795636
15.
Crystal structure of SARS-CoV-2 nsp10/nsp16 2'-O-methylase and its implication on antiviral drug design.
Signal Transduct Target Ther
; 5(1): 131, 2020 07 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32728018