Detalhe da pesquisa
1.
Systematic assessment of the replicability and generalizability of preclinical findings: Impact of protocol harmonization across laboratory sites.
PLoS Biol
; 20(11): e3001886, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36417471
2.
A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease.
Hum Mol Genet
; 23(11): 2995-3007, 2014 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24436303
3.
Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease.
Neurobiol Dis
; 70: 190-203, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24969022
4.
Characterization of behavioral and neuromuscular junction phenotypes in a novel allelic series of SMA mouse models.
Hum Mol Genet
; 21(20): 4431-47, 2012 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22802075
5.
Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment.
J Neurosci
; 32(22): 7454-65, 2012 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-22649225
6.
Enrichment analysis of phenotypic data for drug repurposing in rare diseases.
Front Pharmacol
; 14: 1128562, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37560472
7.
The GBA1 D409V mutation exacerbates synuclein pathology to differing extents in two alpha-synuclein models.
Dis Model Mech
; 15(6)2022 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35419585
8.
Benefits of global mutant huntingtin lowering diminish over time in a Huntington's disease mouse model.
JCI Insight
; 7(20)2022 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36278490
9.
Transcriptional Assessment of Striatal mRNAs as Valid Biomarkers of Disease Progression in Three Mouse Models of Huntington's Disease.
J Huntingtons Dis
; 9(1): 13-31, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32007959
10.
Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington's disease.
Nat Med
; 25(7): 1131-1142, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31263285
11.
Large-scale phenome analysis defines a behavioral signature for Huntington's disease genotype in mice.
Nat Biotechnol
; 34(8): 838-44, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27376585
12.
Non-invasive imaging of GFAP expression after neuronal damage in mice.
Neurosci Lett
; 367(2): 210-2, 2004 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15331155
13.
Cognitive deficits in transgenic and knock-in HTT mice parallel those in Huntington's disease.
J Huntingtons Dis
; 3(2): 145-58, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25062858
14.
The PDE1/5 Inhibitor SCH-51866 Does Not Modify Disease Progression in the R6/2 Mouse Model of Huntington's Disease.
PLoS Curr
; 62014 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24558637
15.
Genetic deletion of transglutaminase 2 does not rescue the phenotypic deficits observed in R6/2 and zQ175 mouse models of Huntington's disease.
PLoS One
; 9(6): e99520, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24955833
16.
Deficits in a Simple Visual Go/No-go Discrimination Task in Two Mouse Models of Huntington's Disease.
PLoS Curr
; 52013 Nov 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24270512
17.
Increased Body Weight of the BAC HD Transgenic Mouse Model of Huntington's Disease Accounts for Some but Not All of the Observed HD-like Motor Deficits.
PLoS Curr
; 52013 Jul 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-24042107
18.
High-Throughput Automated Phenotyping of Two Genetic Mouse Models of Huntington's Disease.
PLoS Curr
; 52013 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23863947
19.
A mixed fixed ratio/progressive ratio procedure reveals an apathy phenotype in the BAC HD and the z_Q175 KI mouse models of Huntington's disease.
PLoS Curr
; 4: e4f972cffe82c0, 2012 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-23925262
20.
Identification of a Maleimide-Based Glycogen Synthase Kinase-3 (GSK-3) Inhibitor, BIP-135, that Prolongs the Median Survival Time of Δ7 SMA KO Mouse Model of Spinal Muscular Atrophy.
ACS Chem Neurosci
; 3(1): 5-11, 2012 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22348181