Detalhe da pesquisa
1.
G protein signaling-biased mu opioid receptor agonists that produce sustained G protein activation are noncompetitive agonists.
Proc Natl Acad Sci U S A
; 118(48)2021 11 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34819362
2.
International Union of Basic and Clinical Pharmacology. CVII. Structure and Pharmacology of the Apelin Receptor with a Recommendation that Elabela/Toddler Is a Second Endogenous Peptide Ligand.
Pharmacol Rev
; 71(4): 467-502, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31492821
3.
Growth/differentiation factor 15 causes TGFß-activated kinase 1-dependent muscle atrophy in pulmonary arterial hypertension.
Thorax
; 74(2): 164-176, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30554141
4.
Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension.
Circulation
; 135(12): 1160-1173, 2017 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28137936
5.
The G Protein Biased Small Molecule Apelin Agonist CMF-019 is Disease Modifying in Endothelial Cell Apoptosis In Vitro and Induces Vasodilatation Without Desensitisation In Vivo.
Front Pharmacol
; 11: 588669, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33716722
6.
Apelin peptides linked to anti-serum albumin domain antibodies retain affinity in vitro and are efficacious receptor agonists in vivo.
Basic Clin Pharmacol Toxicol
; 126 Suppl 6: 96-103, 2020 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-30901161
7.
A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension.
Br J Pharmacol
; 176(9): 1206-1221, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30710493
8.
Chemerin Elicits Potent Constrictor Actions via Chemokine-Like Receptor 1 (CMKLR1), not G-Protein-Coupled Receptor 1 (GPR1), in Human and Rat Vasculature.
J Am Heart Assoc
; 5(10)2016 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27742615
9.
Cardiac action of the first G protein biased small molecule apelin agonist.
Biochem Pharmacol
; 116: 63-72, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27475715