Health Services Access Inequalities in Brazil Result in Poorer Outcomes for Stage III NSCLC-RELANCE/LACOG 0118.

Introduction: Stage III NSCLC is a heterogeneous disease, representing approximately one-third of newly diagnosed lung cancers. Brazil lacks detailed information regarding stage distribution, treatment patterns, survival, and prognostic variables in locally advanced NSCLC. Methods: RELANCE/LACOG 0118 is an observational, retrospective cohort study assessing sociodemographic and clinical data of patients diagnosed with having stage III NSCLC from January 2015 to June 2019, regardless of treatment received. The study was conducted across 13 cancer centers in Brazil. Disease status and survival data were collected up to June 2021. Descriptive statistics, survival analyses, and a multivariable Cox regression model were performed. p values less than 0.05 were considered significant. Results: We recruited 403 patients with stage III NSCLC. Most were male (64.0%), White (31.5%), and smokers or former smokers (86.1%). Most patients had public health insurance (67.5%), had stage IIIA disease (63.2%), and were treated with concurrent chemoradiation (53.1%). The median follow-up time was 33.83 months (95% confidence interval [CI]: 30.43-37.50). Median overall survival (OS) was 27.97 months (95% CI: 21.57-31.73), and median progression-free survival was 11.23 months (95% CI: 10.70-12.77). The type of treatment was independently associated with OS and progression-free survival, whereas the types of health insurance and histology were independent predictors of OS only. Conclusions: Brazilian patients with stage III NSCLC with public health insurance are diagnosed later and have poorer OS. Nevertheless, patients with access to adequate treatment have outcomes similar to those reported in the pivotal trials. Health policy should be improved to make lung cancer diagnosis faster and guarantee prompt access to adequate treatment in Brazil.

Emissöes otoacústicas x Cisplatina: detecçäo precoce da ototoxicidade em pacientes oncológicos / Otoacoustic emissions x Cisplatin: precocious detection of ototoxicity in oncologic patients

Estudos mostram que existem numerosas substâncias reconhecidas como potencialmente ototóxicas e entre as principais, na classe dos medicamentos, destacam-se os quimioterápicos. OBJETIVO: o objetivo deste trabalho foi realizar um estudo da ototoxicidade através das emissöes otoacústicas evocadas - produto de distorçäo (EOA-PD), pré e pós-aplicaçäo do quimioterápico Cisplatina, em indivíduos adultos, moradores da cidade de Blumenau/SC. FORMA DE ESTUDO: Prospectivo clínico. MATERIAL E MÉTODO: Foram estudados 11 indivíduos com patologia oncológica, idade variando entre 29 e 73 anos, através das emissöes otoacústicas evocadas - produto de distorçäo, prévia e posteriormente à aplicaçäo da Cisplatina, utilizando-se o equipamento Madsen Cappela acoplado ao Notebook Toshiba Satélite. RESULTADOS: Os resultados näo mostraram mudanças significativas nas respostas das EOA-PD nas freqüências de 2, 3 e 4 kHz, porém, em 1 e 6 kHz, ocorreram alteraçöes na sensibilidade auditiva, após a aplicaçäo da Cisplatina

Avaliação de Resposta ao Tratamento de Pacientes com Câncer de Testículo / Results evaluation of treatment on patients with testicular cancer

Este trabalho consiste em avaliar a resposta ao tratamento de pacientes portadores de neoplasia maligna de testículo. Foi realizado uma análise retrospectiva de 35 pacientes que apresentaram neoplasias de células germinativas de testículo (NCGT), tratados em instituições de saúde de Florianópolis - SC, no período de março / 83 à dezembro /96