Detalhe da pesquisa
1.
BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment.
Mol Cell
; 67(1): 5-18.e19, 2017 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28673542
2.
Perturbed hematopoiesis in individuals with germline DNMT3A overgrowth Tatton-Brown-Rahman syndrome.
Haematologica
; 107(4): 887-898, 2022 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34092059
3.
BET bromodomain proteins regulate enhancer function during adipogenesis.
Proc Natl Acad Sci U S A
; 115(9): 2144-2149, 2018 02 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-29444854
4.
Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands.
Nat Chem Biol
; 14(4): 405-412, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29507391
5.
Hematologic DNMT3A reduction and high-fat diet synergize to promote weight gain and tissue inflammation.
iScience
; 27(3): 109122, 2024 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38414863
6.
Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain.
Nat Aging
; 3(1): 121-137, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37118510
7.
Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging.
Cell Stem Cell
; 30(5): 689-705.e4, 2023 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37080206
8.
DNMT3A-coordinated splicing governs the stem state switch towards differentiation in embryonic and haematopoietic stem cells.
Nat Cell Biol
; 25(4): 528-539, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37024683
9.
SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation.
Cell Stem Cell
; 30(11): 1503-1519.e8, 2023 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37863054
10.
Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis.
Elife
; 112022 05 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-35635747
11.
Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor.
Cancer Discov
; 12(1): 220-235, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34429321
12.
Modeling IKZF1 lesions in B-ALL reveals distinct chemosensitivity patterns and potential therapeutic vulnerabilities.
Blood Adv
; 5(19): 3876-3890, 2021 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34492683
13.
Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in acute erythroid leukemia onset in mice.
Leukemia
; 35(7): 1949-1963, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33159179
14.
Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion.
Cell Stem Cell
; 27(2): 326-335.e4, 2020 08 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32673568
15.
SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation.
Cell Stem Cell
; 31(2): 275-277, 2024 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38306995
16.
High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program.
Nat Commun
; 10(1): 4358, 2019 09 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-31554818
17.
Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo.
Cell Rep
; 23(1): 1-10, 2018 04 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29617651
18.
Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression.
Cell Rep
; 25(7): 1898-1911.e5, 2018 11 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30428356
19.
Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma.
Nat Genet
; 50(4): 515-523, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29379199
20.
Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer.
Cancer Discov
; 6(9): 1006-21, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27312177