Detalhe da pesquisa
1.
Cancer-associated mutations in VAV1 trigger variegated signaling outputs and T-cell lymphomagenesis.
EMBO J
; 40(22): e108125, 2021 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34617326
2.
Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas.
Proc Natl Acad Sci U S A
; 114(4): 764-769, 2017 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28062691
3.
Clathrin regulates lymphocyte migration by driving actin accumulation at the cellular leading edge.
Eur J Immunol
; 46(10): 2376-2387, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27405273
4.
Endosomal clathrin drives actin accumulation at the immunological synapse.
J Cell Sci
; 124(Pt 5): 820-30, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21321329
5.
Integrin and CD3/TCR activation are regulated by the scaffold protein AKAP450.
Blood
; 115(21): 4174-84, 2010 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-20231423
6.
Characterization of the spectrum of trivalent VAV1-mutation-driven tumours using a gene-edited mouse model.
Mol Oncol
; 16(19): 3533-3553, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35895495
7.
A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors.
Cell Rep
; 38(11): 110522, 2022 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35294890
8.
VAV Proteins as Double Agents in Cancer: Oncogenes with Tumor Suppressor Roles.
Biology (Basel)
; 10(9)2021 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34571765
9.
Distinct Roles of Vav Family Members in Adaptive and Innate Immune Models of Arthritis.
Biomedicines
; 9(6)2021 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34205377
10.
Rho guanosine nucleotide exchange factors are not such bad guys after all in cancera.
Small GTPases
; 11(4): 233-239, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29313423
11.
Computational and in vitro Pharmacodynamics Characterization of 1A-116 Rac1 Inhibitor: Relevance of Trp56 in Its Biological Activity.
Front Cell Dev Biol
; 8: 240, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32351958
12.
Vav2 pharmaco-mimetic mice reveal the therapeutic value and caveats of the catalytic inactivation of a Rho exchange factor.
Oncogene
; 39(28): 5098-5111, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32528129
13.
VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma.
Nat Commun
; 11(1): 4788, 2020 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32963234
14.
Vav proteins maintain epithelial traits in breast cancer cells using miR-200c-dependent and independent mechanisms.
Oncogene
; 38(2): 209-227, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30087437
15.
An unexpected tumor suppressor role for VAV1a.
Mol Cell Oncol
; 5(3): e1432257, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30250888
16.
A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.
Cancer Cell
; 32(5): 608-623.e9, 2017 11 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-29136506
17.
The disease-linked Glu-26-Lys mutant version of Coronin 1A exhibits pleiotropic and pathway-specific signaling defects.
Mol Biol Cell
; 26(16): 2895-912, 2015 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26108624
18.
Immunosuppression-Independent Role of Regulatory T Cells against Hypertension-Driven Renal Dysfunctions.
Mol Cell Biol
; 35(20): 3528-46, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26240279
19.
Miro-1 links mitochondria and microtubule Dynein motors to control lymphocyte migration and polarity.
Mol Cell Biol
; 34(8): 1412-26, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24492963
20.
MTOC translocation modulates IS formation and controls sustained T cell signaling.
J Cell Biol
; 182(5): 951-62, 2008 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-18779373