RESUMO
The purpose of this review is to describe the osteological, neurological, endocrine and dermatological effects of fluoride ingestion. Additional aims are to evaluate whether the Chilean tap water fluoridation program has had any impact on dental health, and analyze the basis for the Chilean elementary school milk fluoridation program, which is targeted at children living in places where tap water has a fluoride concentration less than 0.3 mg/L, without any artificial fluoridation process. We discuss the finding that both public measures have no direct or remarkable effect on dental health, since topical dental hygiene products are the main and most effective contributors to the prevention of dental decay. We also suggest that the permanent and systematic ingestion of fluorides imposes health risks on the population. Therefore, we recommend reevaluating the national fluoridation program for public tap water and the elementary school milk program.
Assuntos
Fluoretação , Política de Saúde , Chile , Fluoretação/efeitos adversos , Fluoretação/legislação & jurisprudência , Fluoretação/normas , HumanosRESUMO
INTRODUCTION: Autism is a common neurodevelopmental condition with a complex genetic aetiology that includes contributions from monogenic and polygenic factors. Many autistic people have unmet healthcare needs that could be served by genomics-informed research and clinical trials. The primary aim of the European Autism GEnomics Registry (EAGER) is to establish a registry of participants with a diagnosis of autism or an associated rare genetic condition who have undergone whole-genome sequencing. The registry can facilitate recruitment for future clinical trials and research studies, based on genetic, clinical and phenotypic profiles, as well as participant preferences. The secondary aim of EAGER is to investigate the association between mental and physical health characteristics and participants' genetic profiles. METHODS AND ANALYSIS: EAGER is a European multisite cohort study and registry and is part of the AIMS-2-TRIALS consortium. EAGER was developed with input from the AIMS-2-TRIALS Autism Representatives and representatives from the rare genetic conditions community. 1500 participants with a diagnosis of autism or an associated rare genetic condition will be recruited at 13 sites across 8 countries. Participants will be given a blood or saliva sample for whole-genome sequencing and answer a series of online questionnaires. Participants may also consent to the study to access pre-existing clinical data. Participants will be added to the EAGER registry and data will be shared externally through established AIMS-2-TRIALS mechanisms. ETHICS AND DISSEMINATION: To date, EAGER has received full ethical approval for 11 out of the 13 sites in the UK (REC 23/SC/0022), Germany (S-375/2023), Portugal (CE-085/2023), Spain (HCB/2023/0038, PIC-164-22), Sweden (Dnr 2023-06737-01), Ireland (230907) and Italy (CET_62/2023, CEL-IRCCS OASI/24-01-2024/EM01, EM 2024-13/1032 EAGER). Findings will be disseminated via scientific publications and conferences but also beyond to participants and the wider community (eg, the AIMS-2-TRIALS website, stakeholder meetings, newsletters).
Assuntos
Transtorno Autístico , Genômica , Sistema de Registros , Sequenciamento Completo do Genoma , Criança , Humanos , Masculino , Transtorno Autístico/genética , Estudos de Coortes , Europa (Continente) , Estudos Multicêntricos como Assunto , Projetos de PesquisaRESUMO
The purpose of this review is to describe the osteological, neurological, endocrine and dermatological effects of fluoride ingestion. Additional aims are to evaluate whether the Chilean tap water fluoridation program has had any impact on dental health, and analyze the basis for the Chilean elementary school milk fluoridation program, which is targeted at children living in places where tap water has a fluoride concentration less than 0.3 mg/L, without any artificial fluoridation process. We discuss the finding that both public measures have no direct or remarkable effect on dental health, since topical dental hygiene products are the main and most effective contributors to the prevention of dental decay. We also suggest that the permanent and systematic ingestion of fluorides imposes health risks on the population. Therefore, we recommend reevaluating the national fluoridation program for public tap water and the elementary school milk program.
Assuntos
Humanos , Fluoretação/efeitos adversos , Fluoretação/legislação & jurisprudência , Fluoretação/normas , Política de Saúde , ChileRESUMO
El Departamento de Medio Ambiente del Colegio Médico de Chile ha concordado una serie de medidas que a su juicio deben ser implementadas por las nuevas autoridades políticas de Chile elegidas, con el fi n de corregir aquellos problemas ambientales que son determinantes de salud poblacional e individual. La implementación de estas medidas deberá impactar positivamente en la salud y calidad de vida de los habitantes de Chile, disminuir la mortalidad aguda y o diferida causada por exposición a diversos contaminantes ambientales. En especial, deberá afectar positivamente a las futuras generaciones al disminuir la exposición prenatal o infantil temprana a agentes que determinan el desarrollo de enfermedades o cambios conductuales más tarde en la vida. Estas proposiciones fueron entregadas a todos los candidatos presidenciales y explicadas en reuniones con cada uno de los 4 candidatos presidenciales que tienen las mejores opciones de de ser electos, de acuerdo a encuestas realizadas en el país.
The Environment Department of the Colegio Médico de Chile (Chilean College of Physicians) agreed a series of measures that should be implemented by the new elected Chilean political authorities, with the purpose of correction the environmental problems which are population and individual health determinants. The implementation of these measures should positively impact Chilean population health and quality of life and decrease acute or delayed mortality caused by exposure to various pollutants. Especially, it should positively affect future generations preventing prenatal or infant exposure to agents determining the development of diseases or behavioural changes later in life. These proposals were delivered to all presidential candidates, and explained in meetings with each of the four presidential candidates with the best perspectives to be elected, according to opinion polls carried out in the country.
Assuntos
Humanos , Meio Ambiente , Nível de Saúde , Política de Saúde , ChileRESUMO
Los efectos en salud de la radiación electromagnética ionizante son bien conocidos; sin embargo hay menos reconocimiento de los efectos en salud causados por exposición a radiación electromagnética no ionizante. La primera parte del presente trabajo se refiere a los efectos en salud de las radiaciones electromagnéticas no ionizantes, independiente de su origen, puesto que no hay diferencias apreciables entre los efectos producidos por los diversos tipos de radiación electromagnética no ionizante y por lo tanto, son también válidas para aquellas emitidas por la telefonía celular. Se describe una asociación estadísticamente significativa de varias enfermedades a radiación electromagnética de frecuencia baja (ELF) proveniente de tendidos o transformadores de alta tensión, radiación electromagnética ELF del tendido eléctrico domiciliario y de artefactos electrodomésticos, exposición ocupacional a radiación electromagnética principalmente ELF, y radiación electromagnética de radiofrecuencia (RF) proveniente de antenas de transmisión de televisión. A continuación se analizan los efectos ya demostrados de la telefonía celular (los teléfonos y sus antenas repetidoras). Luego se analizan los grados de certeza de un estudio del Estado de California (USA) para relacionar las diversas enfermedades causadas por radiación electromagnética no ionizante. Este estudio confirmó la alta o mediana probabilidad de una relación causa-efecto de la radiación electromagnética con las siguientes enfermedades: leucemia en adultos y niños, cáncer cerebral en adultos y niños, cáncer de mama femenino y masculino, abortos espontáneos, suicidio, enfermedad de Alzheimer, esclerosis lateral amiotrófica y enfermedades cardiovasculares incluyendo infarto del miocardio. Se describen cuales son estas enfermedades de acuerdo al origen de estas radiaciones y se analizan cuales pueden ser los mecanismos biológicos que determinan la génesis de éstas...
The health effects of ionizing electromagnetic radiation are well known; neverthless there exist less recognition on the health effects of exposure to non-ionizing electromagnetic radiation. The first part of the present report refers to health effects of non-ionizing electromagnetic radiation, independently of its origin, since there are not important differences among effects caused by the different kind of non-ionizing radiations, therefore, they are valid for those emmited by the mobile telephony. A statistically significant association is described among various diseases and extremely low frequency electromagnetic radiation (ELF) from high tension electric conductors or transformers, intradomiciliary electric lines or electrodomestic appliances, occupational exposure to electromagnetic fields, mainly ELF, and radiofrequency (RF) electromagnetic radiation from television transmission. Already demonstrated effects of mobile telephony (cellular telephones and their antenas). The degrees of certainty from a study of the State of California (USA) is analyzed to relate various diseases caused by non-ionizing radiation. This study confirmed high or moderate probability of a cause-effect relationship for adult and child leukemia, brain cancer in adults and children, female and male breast cancer, spontaneous abortions, suicide, Alzheimer disease, amiotrophic lateral sclerosis and cardiovascular diseases including myocardial infarction. Various diseases are related to the different origin of the radiation, and the biological mechanisms involved in disease generation are analyzed. Research performed in the USSR and afterwards in Russia on health effects of mobile telephony are summarized, these investigations originated the regulation in this country and afterwards in West Europe, and influenced the decisions of WHO on its carcinogenicity...