Detalhe da pesquisa
1.
Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer.
Nature
; 629(8013): 927-936, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38588697
2.
Targeting ROS production through inhibition of NADPH oxidases.
Nat Chem Biol
; 19(12): 1540-1550, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37884805
3.
Mechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers.
J Am Chem Soc
; 2024 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38815248
4.
Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis.
Mol Cancer Ther
; 23(4): 478-491, 2024 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37988559
5.
Discovery and Characterization of Selective, First-in-Class Inhibitors of Citron Kinase.
J Med Chem
; 67(4): 2631-2666, 2024 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38330278
6.
Genetic dependencies associated with transcription factor activities in human cancer cell lines.
Cell Rep
; 43(5): 114175, 2024 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38691456
7.
A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma.
Cancer Res
; 84(6): 872-886, 2024 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38486486
8.
Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers.
Nat Cancer
; 5(1): 66-84, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38151625
9.
Structure-Based Design of Y-Shaped Covalent TEAD Inhibitors.
J Med Chem
; 66(7): 4617-4632, 2023 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36946421
10.
4'-Ethynyl-2'-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress.
Mol Cancer Ther
; 2023 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38064712
11.
Tumor-selective effects of active RAS inhibition in pancreatic ductal adenocarcinoma.
bioRxiv
; 2023 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38105998
12.
Acute pharmacological degradation of ERK5 does not inhibit cellular immune response or proliferation.
Cell Chem Biol
; 29(11): 1630-1638.e7, 2022 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36220104
13.
INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors.
Cancer Discov
; 12(2): 356-371, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34544752
14.
Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling.
Elife
; 112022 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36300789