Detalhe da pesquisa
1.
PCSK9 inhibition attenuates alcohol-associated neuronal oxidative stress and cellular injury.
Brain Behav Immun
; 119: 494-506, 2024 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-38657842
2.
Alcohol use disorder is associated with DNA methylation-based shortening of telomere length and regulated by TESPA1: implications for aging.
Mol Psychiatry
; 27(9): 3875-3884, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35705636
3.
Epigenome-wide association study of alcohol consumption in N = 8161 individuals and relevance to alcohol use disorder pathophysiology: identification of the cystine/glutamate transporter SLC7A11 as a top target.
Mol Psychiatry
; 27(3): 1754-1764, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34857913
4.
Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780,000 participants.
Mol Psychiatry
; 26(4): 1119-1132, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31649322
5.
Epigenome-wide association study and multi-tissue replication of individuals with alcohol use disorder: evidence for abnormal glucocorticoid signaling pathway gene regulation.
Mol Psychiatry
; 26(6): 2224-2237, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32398718
6.
Evaluating the relationship between alcohol consumption, tobacco use, and cardiovascular disease: A multivariable Mendelian randomization study.
PLoS Med
; 17(12): e1003410, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33275596
7.
Adverse Childhood Experiences are Associated with High-Intensity Binge Drinking Behavior in Adulthood and Mediated by Psychiatric Disorders.
Alcohol Alcohol
; 55(2): 204-214, 2020 Mar 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31895420
8.
PCSK9 is Increased in Cerebrospinal Fluid of Individuals With Alcohol Use Disorder.
Alcohol Clin Exp Res
; 43(6): 1163-1169, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30933362
9.
Lack of Association Between Serotonin Transporter Gene (SLC6A4) Promoter Methylation and Amygdala Response During Negative Emotion Processing in Individuals With Alcohol Dependence.
Alcohol Alcohol
; 54(3): 209-215, 2019 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31008507
10.
Genetic Association and Expression Analyses of the Phosphatidylinositol-4-Phosphate 5-Kinase (PIP5K1C) Gene in Alcohol Use Disorder-Relevance for Pain Signaling and Alcohol Use.
Alcohol Clin Exp Res
; 42(6): 1034-1043, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29667742
11.
Assessing the Impact of PCSK9 and HMGCR Inhibition on Liver Function: Drug-Target Mendelian Randomization Analyses in Four Ancestries.
Cell Mol Gastroenterol Hepatol
; 17(1): 29-40, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-37703945
12.
Major Psychiatric Disorders, Substance Use Behaviors, and Longevity.
JAMA Psychiatry
; 2024 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38888899
13.
LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic ß cells.
Cell Rep
; 43(4): 114047, 2024 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38607916
14.
Investigating the impact of metabolic syndrome traits on telomere length: a Mendelian randomization study.
Obesity (Silver Spring)
; 31(8): 2189-2198, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37415075
15.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) in the central nervous system.
Neurosci Biobehav Rev
; 149: 105155, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37019248
16.
Multi-omic underpinnings of epigenetic aging and human longevity.
Nat Commun
; 14(1): 2236, 2023 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37076473
17.
Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging.
Nat Aging
; 3(8): 1020-1035, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37550455
18.
Additive Effects of Stress and Alcohol Exposure on Accelerated Epigenetic Aging in Alcohol Use Disorder.
Biol Psychiatry
; 93(4): 331-341, 2023 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36182531
19.
Association Between Brain Structure and Alcohol Use Behaviors in Adults: A Mendelian Randomization and Multiomics Study.
JAMA Psychiatry
; 79(9): 869-878, 2022 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35947372
20.
Mendelian Randomization Study of PCSK9 and HMG-CoA Reductase Inhibition and Cognitive Function.
J Am Coll Cardiol
; 80(7): 653-662, 2022 08 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35953131