Detalhe da pesquisa
1.
Comprehensive evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of C9orf72 disease.
Proc Natl Acad Sci U S A
; 119(49): e2123487119, 2022 12 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36454749
2.
Investigating small molecules to inhibit germinal center kinase-like kinase (GLK/MAP4K3) upstream of PKCθ phosphorylation: Potential therapy to modulate T cell dependent immunity.
Bioorg Med Chem Lett
; 28(10): 1964-1971, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29636220
3.
Production of poly(GA) in C9ORF72 patient motor neurons derived from induced pluripotent stem cells.
Acta Neuropathol
; 138(6): 1099-1101, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31624870
4.
Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site.
Structure
; 16(5): 798-808, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18462684
5.
Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site.
MAbs
; 12(1): 1713648, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-31928294
6.
Antibody Therapy Targeting RAN Proteins Rescues C9 ALS/FTD Phenotypes in C9orf72 Mouse Model.
Neuron
; 105(4): 645-662.e11, 2020 02 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31831332
7.
Engineering potent long-acting variants of the Wnt inhibitor DKK2.
Protein Eng Des Sel
; 30(5): 359-372, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28180900
8.
Germinal-center kinase-like kinase co-crystal structure reveals a swapped activation loop and C-terminal extension.
Protein Sci
; 26(2): 152-162, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27727493
9.
Affinity enhancement of an in vivo matured therapeutic antibody using structure-based computational design.
Protein Sci
; 15(5): 949-60, 2006 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-16597831
10.
Structure activity relationships of monocyte chemoattractant proteins in complex with a blocking antibody.
Protein Eng Des Sel
; 19(7): 317-24, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16682434
11.
Artemin crystal structure reveals insights into heparan sulfate binding.
Biochemistry
; 45(22): 6801-12, 2006 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-16734417
12.
Soluble peptide-MHC monomers cause activation of CD8+ T cells through transfer of the peptide to T cell MHC molecules.
Proc Natl Acad Sci U S A
; 99(21): 13729-34, 2002 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12374859
13.
Monoclonal antibodies specific for the empty conformation of HLA-DR1 reveal aspects of the conformational change associated with peptide binding.
J Biol Chem
; 279(16): 16561-70, 2004 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-14757758