Pesquisa | BVS Integralidade em Saúde

1.

The ectonucleotidase CD39 identifies tumor-reactive CD8⁺ T cells predictive of immune checkpoint blockade efficacy in human lung cancer.

Chow, Andrew; Uddin, Fathema Z; Liu, Michael; Dobrin, Anton; Nabet, Barzin Y; Mangarin, Levi; Lavin, Yonit; Rizvi, Hira; Tischfield, Sam E; Quintanal-Villalonga, Alvaro; Chan, Joseph M; Shah, Nisargbhai; Allaj, Viola; Manoj, Parvathy; Mattar, Marissa; Meneses, Maximiliano; Landau, Rebecca; Ward, Mariana; Kulick, Amanda; Kwong, Charlene; Wierzbicki, Matthew; Yavner, Jessica; Egger, Jacklynn; Chavan, Shweta S; Farillas, Abigail; Holland, Aliya; Sridhar, Harsha; Ciampricotti, Metamia; Hirschhorn, Daniel; Guan, Xiangnan; Richards, Allison L; Heller, Glenn; Mansilla-Soto, Jorge; Sadelain, Michel; Klebanoff, Christopher A; Hellmann, Matthew D; Sen, Triparna; de Stanchina, Elisa; Wolchok, Jedd D; Merghoub, Taha; Rudin, Charles M.

Immunity ; 56(1): 93-106.e6, 2023 01 10.

Artigo em Inglês | MEDLINE | ID: mdl-36574773

2.

CD19 CAR T Cells.

Sadelain, Michel.

Cell ; 171(7): 1471, 2017 Dec 14.

Artigo em Inglês | MEDLINE | ID: mdl-29245005

3.

TET2 guards against unchecked BATF3-induced CAR T cell expansion.

Jain, Nayan; Zhao, Zeguo; Feucht, Judith; Koche, Richard; Iyer, Archana; Dobrin, Anton; Mansilla-Soto, Jorge; Yang, Julie; Zhan, Yingqian; Lopez, Michael; Gunset, Gertrude; Sadelain, Michel.

Nature ; 615(7951): 315-322, 2023 03.

Artigo em Inglês | MEDLINE | ID: mdl-36755094

4.

Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer.

Rojas, Luis A; Sethna, Zachary; Soares, Kevin C; Olcese, Cristina; Pang, Nan; Patterson, Erin; Lihm, Jayon; Ceglia, Nicholas; Guasp, Pablo; Chu, Alexander; Yu, Rebecca; Chandra, Adrienne Kaya; Waters, Theresa; Ruan, Jennifer; Amisaki, Masataka; Zebboudj, Abderezak; Odgerel, Zagaa; Payne, George; Derhovanessian, Evelyna; Müller, Felicitas; Rhee, Ina; Yadav, Mahesh; Dobrin, Anton; Sadelain, Michel; Luksza, Marta; Cohen, Noah; Tang, Laura; Basturk, Olca; Gönen, Mithat; Katz, Seth; Do, Richard Kinh; Epstein, Andrew S; Momtaz, Parisa; Park, Wungki; Sugarman, Ryan; Varghese, Anna M; Won, Elizabeth; Desai, Avni; Wei, Alice C; D'Angelica, Michael I; Kingham, T Peter; Mellman, Ira; Merghoub, Taha; Wolchok, Jedd D; Sahin, Ugur; Türeci, Özlem; Greenbaum, Benjamin D; Jarnagin, William R; Drebin, Jeffrey; O'Reilly, Eileen M.

Nature ; 618(7963): 144-150, 2023 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-37165196

5.

Neoantigen quality predicts immunoediting in survivors of pancreatic cancer.

Luksza, Marta; Sethna, Zachary M; Rojas, Luis A; Lihm, Jayon; Bravi, Barbara; Elhanati, Yuval; Soares, Kevin; Amisaki, Masataka; Dobrin, Anton; Hoyos, David; Guasp, Pablo; Zebboudj, Abderezak; Yu, Rebecca; Chandra, Adrienne Kaya; Waters, Theresa; Odgerel, Zagaa; Leung, Joanne; Kappagantula, Rajya; Makohon-Moore, Alvin; Johns, Amber; Gill, Anthony; Gigoux, Mathieu; Wolchok, Jedd; Merghoub, Taha; Sadelain, Michel; Patterson, Erin; Monasson, Remi; Mora, Thierry; Walczak, Aleksandra M; Cocco, Simona; Iacobuzio-Donahue, Christine; Greenbaum, Benjamin D; Balachandran, Vinod P.

Nature ; 606(7913): 389-395, 2022 06.

Artigo em Inglês | MEDLINE | ID: mdl-35589842

6.

Senolytic CAR T cells reverse senescence-associated pathologies.

Amor, Corina; Feucht, Judith; Leibold, Josef; Ho, Yu-Jui; Zhu, Changyu; Alonso-Curbelo, Direna; Mansilla-Soto, Jorge; Boyer, Jacob A; Li, Xiang; Giavridis, Theodoros; Kulick, Amanda; Houlihan, Shauna; Peerschke, Ellinor; Friedman, Scott L; Ponomarev, Vladimir; Piersigilli, Alessandra; Sadelain, Michel; Lowe, Scott W.

Nature ; 583(7814): 127-132, 2020 07.

Artigo em Inglês | MEDLINE | ID: mdl-32555459

7.

Novel extragenic genomic safe harbors for precise therapeutic T-cell engineering.

Odak, Ashlesha; Yuan, Han; Feucht, Judith; Cantu, Vito Adrian; Mansilla-Soto, Jorge; Kogel, Friederike; Eyquem, Justin; Everett, John; Bushman, Frederic D; Leslie, Christina S; Sadelain, Michel.

Blood ; 141(22): 2698-2712, 2023 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-36745870

8.

CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape.

Hamieh, Mohamad; Dobrin, Anton; Cabriolu, Annalisa; van der Stegen, Sjoukje J C; Giavridis, Theodoros; Mansilla-Soto, Jorge; Eyquem, Justin; Zhao, Zeguo; Whitlock, Benjamin M; Miele, Matthew M; Li, Zhuoning; Cunanan, Kristen M; Huse, Morgan; Hendrickson, Ronald C; Wang, Xiuyan; Rivière, Isabelle; Sadelain, Michel.

Nature ; 568(7750): 112-116, 2019 04.

Artigo em Inglês | MEDLINE | ID: mdl-30918399

9.

Author Correction: Senolytic CAR T cells reverse senescence-associated pathologies.

Amor, Corina; Feucht, Judith; Leibold, Josef; Ho, Yu-Jui; Zhu, Changyu; Alonso-Curbelo, Direna; Mansilla-Soto, Jorge; Boyer, Jacob A; Li, Xiang; Giavridis, Theodoros; Kulick, Amanda; Houlihan, Shauna; Peerschke, Ellinor; Friedman, Scott L; Ponomarev, Vladimir; Piersigilli, Alessandra; Sadelain, Michel; Lowe, Scott W.

Nature ; 627(8004): E9, 2024 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-38383793

10.

GLUT1 overexpression enhances CAR T cell metabolic fitness and anti-tumor efficacy.

Shi, Yuzhe; Kotchetkov, Ivan S; Dobrin, Anton; Hanina, Sophie A; Rajasekhar, Vinagolu K; Healey, John H; Sadelain, Michel.

Mol Ther ; 2024 May 07.

Artigo em Inglês | MEDLINE | ID: mdl-38720457

11.

Interventions and outcomes of adult patients with B-ALL progressing after CD19 chimeric antigen receptor T-cell therapy.

Wudhikarn, Kitsada; Flynn, Jessica R; Rivière, Isabelle; Gönen, Mithat; Wang, Xiuyan; Senechal, Brigitte; Curran, Kevin J; Roshal, Mikhail; Maslak, Peter G; Geyer, Mark B; Halton, Elizabeth F; Diamonte, Claudia; Davila, Marco L; Sadelain, Michel; Brentjens, Renier J; Park, Jae H.

Blood ; 138(7): 531-543, 2021 08 19.

Artigo em Inglês | MEDLINE | ID: mdl-33851211

12.

Therapeutic T cell engineering.

Sadelain, Michel; Rivière, Isabelle; Riddell, Stanley.

Nature ; 545(7655): 423-431, 2017 05 24.

Artigo em Inglês | MEDLINE | ID: mdl-28541315

13.

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection.

Eyquem, Justin; Mansilla-Soto, Jorge; Giavridis, Theodoros; van der Stegen, Sjoukje J C; Hamieh, Mohamad; Cunanan, Kristen M; Odak, Ashlesha; Gönen, Mithat; Sadelain, Michel.

Nature ; 543(7643): 113-117, 2017 03 02.

Artigo em Inglês | MEDLINE | ID: mdl-28225754

14.

Globin vector regulatory elements are active in early hematopoietic progenitor cells.

Cabriolu, Annalisa; Odak, Ashlesha; Zamparo, Lee; Yuan, Han; Leslie, Christina S; Sadelain, Michel.

Mol Ther ; 30(6): 2199-2209, 2022 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-35247584

15.

CAR T cells: Building on the CD19 paradigm.

Globerson Levin, Anat; Rivière, Isabelle; Eshhar, Zelig; Sadelain, Michel.

Eur J Immunol ; 51(9): 2151-2163, 2021 09.

Artigo em Inglês | MEDLINE | ID: mdl-34196410

16.

Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia.

Park, Jae H; Rivière, Isabelle; Gonen, Mithat; Wang, Xiuyan; Sénéchal, Brigitte; Curran, Kevin J; Sauter, Craig; Wang, Yongzeng; Santomasso, Bianca; Mead, Elena; Roshal, Mikhail; Maslak, Peter; Davila, Marco; Brentjens, Renier J; Sadelain, Michel.

N Engl J Med ; 378(5): 449-459, 2018 02 01.

Artigo em Inglês | MEDLINE | ID: mdl-29385376

17.

Evidence for continued dose escalation of plerixafor for hematopoietic progenitor cell collections in sickle cell disease.

Boulad, Farid; Zhang, Jiahao; Yazdanbakhsh, Karina; Sadelain, Michel; Shi, Patricia A.

Blood Cells Mol Dis ; 90: 102588, 2021 09.

Artigo em Inglês | MEDLINE | ID: mdl-34166998

18.

CD19 CAR T cells following autologous transplantation in poor-risk relapsed and refractory B-cell non-Hodgkin lymphoma.

Sauter, Craig S; Senechal, Brigitte; Rivière, Isabelle; Ni, Ai; Bernal, Yvette; Wang, Xiuyan; Purdon, Terence; Hall, Malloury; Singh, Ashvin N; Szenes, Victoria Z; Yoo, Sarah; Dogan, Ahmet; Wang, Yongzeng; Moskowitz, Craig H; Giralt, Sergio; Matasar, Matthew J; Perales, Miguel-Angel; Curran, Kevin J; Park, Jae; Sadelain, Michel; Brentjens, Renier J.

Blood ; 134(7): 626-635, 2019 08 15.

Artigo em Inglês | MEDLINE | ID: mdl-31262783

19.

Toxicity and response after CD19-specific CAR T-cell therapy in pediatric/young adult relapsed/refractory B-ALL.

Curran, Kevin J; Margossian, Steven P; Kernan, Nancy A; Silverman, Lewis B; Williams, David A; Shukla, Neerav; Kobos, Rachel; Forlenza, Christopher J; Steinherz, Peter; Prockop, Susan; Boulad, Farid; Spitzer, Barbara; Cancio, Maria I; Boelens, Jaap Jan; Kung, Andrew L; Khakoo, Yasmin; Szenes, Victoria; Park, Jae H; Sauter, Craig S; Heller, Glenn; Wang, Xiuyan; Senechal, Brigitte; O'Reilly, Richard J; Riviere, Isabelle; Sadelain, Michel; Brentjens, Renier J.

Blood ; 134(26): 2361-2368, 2019 12 26.

Artigo em Inglês | MEDLINE | ID: mdl-31650176

20.

Process and procedural adjustments to improve CD34+ collection efficiency of hematopoietic progenitor cell collections in sickle cell disease.

Avecilla, Scott T; Boulad, Farid; Yazdanbakhsh, Karina; Sadelain, Michel; Shi, Patricia A.

Transfusion ; 61(9): 2775-2781, 2021 09.

Artigo em Inglês | MEDLINE | ID: mdl-34160085

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