Detalhe da pesquisa
1.
Identification of PARP14 inhibitors using novel methods for detecting auto-ribosylation.
Biochem Biophys Res Commun
; 486(3): 626-631, 2017 05 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28315326
2.
Accelerating antiviral drug discovery: lessons from COVID-19.
Nat Rev Drug Discov
; 22(7): 585-603, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37173515
3.
Target 2035 - an update on private sector contributions.
RSC Med Chem
; 14(6): 1002-1011, 2023 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37360399
4.
Target 2035 - update on the quest for a probe for every protein.
RSC Med Chem
; 13(1): 13-21, 2022 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-35211674
5.
CACHE (Critical Assessment of Computational Hit-finding Experiments): A public-private partnership benchmarking initiative to enable the development of computational methods for hit-finding.
Nat Rev Chem
; 6(4): 287-295, 2022 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-35783295
6.
Discovery of Novel and Highly Selective Cyclopropane ALK Inhibitors through a Fragment-Assisted, Structure-Based Drug Design.
ACS Omega
; 5(49): 31984-32001, 2020 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33344853
7.
TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma.
Oncotarget
; 9(26): 18480-18493, 2018 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29719619
8.
Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1''-phosphate dephosphorylation by a conserved domain of nsP3.
Structure
; 13(11): 1665-75, 2005 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16271890
9.
Structure of a conserved hypothetical protein SA1388 from S. aureus reveals a capped hexameric toroid with two PII domain lids and a dinuclear metal center.
BMC Struct Biol
; 6: 27, 2006 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-17187687
10.
Crystal structure of MtnX phosphatase from Bacillus subtilis at 2.0 angstroms resolution provides a structural basis for bipartite phosphomonoester hydrolysis of 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate.
Proteins
; 69(2): 433-9, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17654724
11.
Crystal structure and DNA binding of the homeodomain of the stem cell transcription factor Nanog.
J Mol Biol
; 376(3): 758-70, 2008 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-18177668
12.
Ribonucleocapsid formation of severe acute respiratory syndrome coronavirus through molecular action of the N-terminal domain of N protein.
J Virol
; 81(8): 3913-21, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17229691
13.
Crystal structure of a monomeric form of severe acute respiratory syndrome coronavirus endonuclease nsp15 suggests a role for hexamerization as an allosteric switch.
J Virol
; 81(12): 6700-8, 2007 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-17409150
14.
Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme.
Proc Natl Acad Sci U S A
; 103(15): 5717-22, 2006 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-16581910
15.
Crystal structure of nonstructural protein 10 from the severe acute respiratory syndrome coronavirus reveals a novel fold with two zinc-binding motifs.
J Virol
; 80(16): 7894-901, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16873246