Detalhe da pesquisa
1.
The 3-phosphoinositide-dependent protein kinase 1 is an essential upstream activator of protein kinase A in malaria parasites.
PLoS Biol
; 19(12): e3001483, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34879056
2.
In vitro activity of anti-malarial ozonides against an artemisinin-resistant isolate.
Malar J
; 16(1): 45, 2017 01 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28122617
3.
Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling.
PLoS Med
; 13(10): e1002138, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-27701420
4.
Identification and deconvolution of cross-resistance signals from antimalarial compounds using multidrug-resistant Plasmodium falciparum strains.
Antimicrob Agents Chemother
; 59(2): 1110-8, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25487796
5.
Novel synthetic route for antimalarial benzo[a]phenoxazine derivative SSJ-183 and two active metabolites.
Bioorg Med Chem
; 22(14): 3749-52, 2014 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24856305
6.
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria.
Proc Natl Acad Sci U S A
; 108(11): 4400-5, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21300861
7.
Incomplete Plasmodium falciparum growth inhibition following piperaquine treatment translates into increased parasite viability in the in vitro parasite reduction ratio assay.
Front Cell Infect Microbiol
; 14: 1396786, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38746786
8.
Fast in vitro methods to determine the speed of action and the stage-specificity of anti-malarials in Plasmodium falciparum.
Malar J
; 12: 424, 2013 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-24237770
9.
A Pyridyl-Furan Series Developed from the Open Global Health Library Block Red Blood Cell Invasion and Protein Trafficking in Plasmodium falciparum through Potential Inhibition of the Parasite's PI4KIIIB Enzyme.
ACS Infect Dis
; 9(9): 1695-1710, 2023 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37639221
10.
Antimalarial Dibenzannulated Medium-Ring Keto Lactams.
ACS Infect Dis
; 9(10): 1964-1980, 2023 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37695781
11.
The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites.
PLoS Med
; 9(2): e1001169, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22363211
12.
Sorption of Nanomaterials to Sandstone Rock.
Nanomaterials (Basel)
; 12(2)2022 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35055219
13.
The catalytic subunit of Plasmodium falciparum casein kinase 2 is essential for gametocytogenesis.
Commun Biol
; 4(1): 336, 2021 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33712726
14.
Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439.
ACS Infect Dis
; 7(7): 1885-1893, 2021 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34101429
15.
The comparative antimalarial properties of weak base and neutral synthetic ozonides.
Bioorg Med Chem Lett
; 20(2): 563-6, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19962893
16.
Identification of an antimalarial synthetic trioxolane drug development candidate.
Nature
; 430(7002): 900-4, 2004 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-15318224
17.
Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity.
Bioorg Med Chem Lett
; 19(16): 4542-5, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19616946
18.
Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum.
Sci Transl Med
; 11(510)2019 09 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31534021
19.
In vitro assessment of the pharmacodynamic properties of DB75, piperaquine, OZ277 and OZ401 in cultures of Plasmodium falciparum.
J Antimicrob Chemother
; 62(5): 1061-4, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18669520
20.
Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277.
Bioorg Med Chem Lett
; 18(5): 1555-8, 2008 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18262417