Detalhe da pesquisa
1.
A phase I/II study of ARO-HSD, an RNA interference therapeutic, for the treatment of non-alcoholic steatohepatitis.
J Hepatol
; 78(4): 684-692, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36513186
2.
Combination treatments including the small-interfering RNA JNJ-3989 induce rapid and sometimes prolonged viral responses in patients with CHB.
J Hepatol
; 77(5): 1287-1298, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35870702
3.
Safety, antiviral activity and pharmacokinetics of JNJ-64530440, a novel capsid assembly modulator, as 4 week monotherapy in treatment-naive patients with chronic hepatitis B virus infection.
J Antimicrob Chemother
; 77(4): 1102-1110, 2022 03 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-35040959
4.
A Five-in-One First-in-Human Study To Assess Safety, Tolerability, and Pharmacokinetics of RO7049389, an Inhibitor of Hepatitis B Virus Capsid Assembly, after Single and Multiple Ascending Doses in Healthy Participants.
Antimicrob Agents Chemother
; 64(11)2020 10 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32839221
5.
Long-term Benefits of Sustained Virologic Response for Patient-Reported Outcomes in Patients With Chronic Hepatitis C Virus Infection.
Clin Gastroenterol Hepatol
; 18(2): 468-476.e11, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31376493
6.
Antiviral Activity, Safety, and Pharmacokinetics of Capsid Assembly Modulator NVR 3-778 in Patients with Chronic HBV Infection.
Gastroenterology
; 156(5): 1392-1403.e7, 2019 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-30625297
7.
Anti-PD-1 blockade with nivolumab with and without therapeutic vaccination for virally suppressed chronic hepatitis B: A pilot study.
J Hepatol
; 71(5): 900-907, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31306680
8.
Effects of BI 655064, an antagonistic anti-CD40 antibody, on clinical and biomarker variables in patients with active rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase IIa study.
Ann Rheum Dis
; 78(6): 754-760, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30902820
9.
Short-Duration AL-335, Odalasvir, With or Without Simeprevir, in Patients With HCV GT1 or 3 Infection Without Cirrhosis.
Hepatology
; 68(6): 2145-2157, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30070722
10.
A comparative pharmacokinetic study of DRL_BZ, a candidate biosimilar of bevacizumab, with Avastin® (EU and US) in healthy male subjects.
Br J Clin Pharmacol
; 84(10): 2352-2364, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29943831
11.
Randomized, controlled study of bleselumab (ASKP1240) pharmacokinetics and safety in patients with moderate-to-severe plaque psoriasis.
Biopharm Drug Dispos
; 39(5): 245-255, 2018 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-29679478
12.
Efficacy of the Combination of Sofosbuvir, Velpatasvir, and the NS3/4A Protease Inhibitor GS-9857 in Treatment-Naïve or Previously Treated Patients With Hepatitis C Virus Genotype 1 or 3 Infections.
Gastroenterology
; 151(3): 448-456.e1, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27240903
13.
A multicenter, randomized, open-label, 2-arm parallel study to compare the pharmacokinetics, safety and tolerability of AVT02 administered subcutaneously via prefilled syringe or autoinjector in healthy adults.
Expert Opin Biol Ther
; 23(8): 773-780, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36197309
14.
Population pharmacokinetic/pharmacodynamic models of JNJ-64794964, a toll-like receptor 7 agonist, in healthy adult participants.
Antivir Ther
; 28(1): 13596535231151626, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36691849
15.
A single, oral dose of the TLR7 agonist JNJ-64794964 induces transcriptomic and phenotypic changes in peripheral immune cells in healthy adults.
Antivir Ther
; 28(3): 13596535231172878, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37199270
16.
RNA interference targeting ANGPTL3 for triglyceride and cholesterol lowering: phase 1 basket trial cohorts.
Nat Med
; 29(9): 2216-2223, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37626170
17.
RNA Interference Therapy Targeting Apolipoprotein C-III in Hypertriglyceridemia.
NEJM Evid
; 2(12): EVIDoa2200325, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-38320498
18.
Replacement of disulfides by amide bonds in the relaxin-like factor (RLF/INSL3) reveals a role for the A11-B10 link in transmembrane signaling.
Biochemistry
; 51(20): 4198-205, 2012 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22574850
19.
Pharmacokinetics and pharmacodynamics of a proposed tocilizumab biosimilar MSB11456 versus both the US-licensed and EU-approved products: a randomized, double-blind trial.
Expert Rev Clin Immunol
; 18(5): 533-543, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35354411
20.
A randomized, adaptive design, double-blind, 3-arm, parallel study assessing the pharmacokinetics and safety of AVT02, a high-concentration (100 mg/mL) Adalimumab biosimilar, in healthy adult subjects (ALVOPAD FIRST).
Expert Opin Investig Drugs
; 31(9): 965-976, 2022 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-35107050