Detalhe da pesquisa
1.
Simultaneous Exposure to Intracellular and Extracellular Photosensitizers for the Treatment of Staphylococcus aureus Infections.
Antimicrob Agents Chemother
; 65(12): e0091921, 2021 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34516248
2.
Safety, Pharmacokinetics, and Activity of High-Dose Ivermectin and Chloroquine against the Liver Stage of Plasmodium cynomolgi Infection in Rhesus Macaques.
Antimicrob Agents Chemother
; 64(9)2020 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32660993
3.
Updating the modified Thompson test by using whole-body bioluminescence imaging to replace traditional efficacy testing in experimental models of murine malaria.
Malar J
; 18(1): 38, 2019 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30767768
4.
Differential cytochrome P450 2D metabolism alters tafenoquine pharmacokinetics.
Antimicrob Agents Chemother
; 59(7): 3864-9, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25870069
5.
Differential CYP 2D6 metabolism alters primaquine pharmacokinetics.
Antimicrob Agents Chemother
; 59(4): 2380-7, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25645856
6.
The synthesis, antimalarial activity and CoMFA analysis of novel aminoalkylated quercetin analogs.
Bioorg Med Chem Lett
; 25(2): 327-32, 2015 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25488841
7.
Investigation into novel thiophene- and furan-based 4-amino-7-chloroquinolines afforded antimalarials that cure mice.
Bioorg Med Chem
; 23(9): 2176-86, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25801154
8.
Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds.
Malar J
; 13: 2, 2014 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24386891
9.
CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever.
Malar J
; 12: 214, 2013 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23800033
10.
3,5-bis(benzylidene)-4-piperidones and related N-acyl analogs: a novel cluster of antimalarials targeting the liver stage of Plasmodium falciparum.
Bioorg Med Chem
; 21(23): 7250-6, 2013 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24139941
11.
CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine.
Malar J
; 11: 259, 2012 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-22856549
12.
Combination of Subtherapeutic Doses of Tretazicar and Liposomal Amphotericin B Suppresses and Cures Leishmania major-Induced Cutaneous Lesions in Murine Models.
ACS Infect Dis
; 7(2): 506-517, 2021 02 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33529014
13.
Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites.
Sci Rep
; 11(1): 2121, 2021 01 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33483532
14.
Structure-Bioactivity Relationships of Lapatinib Derived Analogs against Schistosoma mansoni.
ACS Med Chem Lett
; 11(3): 258-265, 2020 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32184954
15.
Torin 2 Derivative, NCATS-SM3710, Has Potent Multistage Antimalarial Activity through Inhibition of P. falciparum Phosphatidylinositol 4-Kinase (Pfâ¯PI4KIIIß).
ACS Pharmacol Transl Sci
; 3(5): 948-964, 2020 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33073193
16.
Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors.
ACS Med Chem Lett
; 11(3): 249-257, 2020 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32184953
17.
Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases.
J Med Chem
; 63(19): 10773-10781, 2020 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32667203
18.
Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials.
J Med Chem
; 63(11): 6179-6202, 2020 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32390431
19.
5-(2-Pyrimidinyl)-imidazo[1,2-a]pyridines are antibacterial agents targeting the ATPase domains of DNA gyrase and topoisomerase IV.
Bioorg Med Chem Lett
; 19(18): 5302-6, 2009 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19683922
20.
Novel benzoxaborole, nitroimidazole and aminopyrazoles with activity against experimental cutaneous leishmaniasis.
Int J Parasitol Drugs Drug Resist
; 11: 129-138, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30922847