[Exercise stress test: prognostic value for elderly patients with stable coronary atherosclerosis]. / Teste ergométrico: valor prognóstico em pacientes idosos com doença aterosclerótica coronariana estável.

OBJECTIVE: To study the prognostic value of exercise stress test variables in elderly patients with coronary atherosclerosis and exercise-induced ischemia. METHODS: Sixty-four elderly patients (61 men, 73 +/- 5 years old) with coronary atherosclerosis, verified by cardiac catheterization, that were clinically stable, had a left ventricle ejection fraction greater than or equal to 0.40 and developed myocardial ischemia during the exercise stress test were studied. The patients were evaluated every six months for cardiac events (death, myocardial infarction, unstable angina, angioplasty and myocardial revascularization). RESULTS: After a mean follow-up period of 48 months, 23 (36%) patients suffered cardiac events. There was no clinical or angiographical differences among the patients that suffered cardiac events and those that did not. Using multivariate analysis, the presence of chest pain during the exercise stress test (relative risk 2.668, p = 0.031) and the heart rate at the onset of ischemia (relative risk 0.966, p = 0.009) were associated with cardiac events. CONCLUSION: In this elderly population, the presence of chest pain during the exercise stress test and the heart rate at the onset of ischemia were associated with cardiac events. These variables could be useful for risk evaluation in patients with stable coronary atherosclerosis.

Long-term prognostic value of triiodothyronine concentration in elderly patients with heart failure.

In this study the authors sought to determine the prevalence and long-term prognostic value of low triiodothyronine levels in elderly patients with heart failure and no thyroid disease. Lower levels of triiodothyronine are more prevalent in patients with advanced heart failure without thyroid disease, and this may have prognostic implications. However, this hormonal milieu has not been investigated in elderly patients. The authors prospectively followed a consecutive sample of 69 elderly patients aged 76.5+/-5.9 years with heart failure and 44 age-matched controls without heart failure between March 1997 and September 2000 at the Geriatric Cardiology Outpatient Clinic of the Heart Institute of Sao Paulo, Brazil. Events analyzed included death, hospitalization, and the combined end point of death or hospitalization. The study revealed that levels of triiodothyronine were lower in heart failure patients than in controls (89+/-23 vs. 101+/-16 ng/dL, p=0.001). During the follow-up period of 14.3+/-8.1 months there were 19 deaths and 33 hospitalizations in the heart failure group. The combined end point of death or hospitalization occurred in 38 patients. Triiodothyronine levels were lower in heart failure patients who had a cardiovascular event than in event-free patients (82.7+/-24.8 vs. 96.7+/-19.2 ng/dL, p=0.012). The odds ratio for events was 9.8 (95% confidence interval, 2.2-43, p=0.004) for patients in the lowest tertile of triiodothyronine, that is, lower than 80 ng/dL, compared with patients with levels above 80 ng/dL. The authors conclude that among elderly patients with heart failure, lower triiodothyronine concentrations are more prevalent and are associated with a worse prognosis.

Relation between the behaviors of P-wave and QT dispersions in elderly patients with heart failure.

OBJECTIVE: To assess the relation between P-wave and QT dispersions in elderly patients with heart failure. METHODS: Forty-seven elderly patients (75.6+/-6 years) with stable heart failure in NYHA functional classes II or III and with ejection fractions of 37+/-6% underwent body surface mapping to analyze P-wave and QT dispersions. The degree of correlation between P-wave and QT dispersions was assessed, and P-wave dispersion values in patients with QT dispersion greater than and smaller than 100 ms were compared. RESULTS: The mean values of P-wave and QT dispersions were 54+/-14 ms and 68+/-27 ms, respectively. The correlation between the 2 variables was R=0.41 (p=0.04). In patients with QT dispersion values > 100 ms, P-wave dispersion was significantly greater than in those with QT dispersion values < 100 ms (58+/-16 vs 53+/-12 ms, p=0.04 ). CONCLUSION: Our results suggest that, in elderly patients with heart failure, a correlation between the values of P-wave and QT dispersions exists. These findings may have etiopathogenic, pathophysiologic, prognostic, and therapeutic implications, which should be investigated in other studies.

Strategy for identifying an efficient dosage of beta-blocker for elderly patients with myocardial ischemia and preserved left ventricular function.

OBJECTIVE: To assess the strategy of titration for prescribing an efficient dosage of propranolol to reduce myocardial ischemia in the elderly. METHODS: The study comprised 14 elderly men (73.6 +/- 5.3 years) with stable coronary heart disease documented on coronary cineangiography, ischemic response to exercise testing, and preserved left ventricular function. Titration was performed to identify the dosage of propranolol that would cause a 15% reduction in heart rate at the end of a 50 W load (corresponding to normal daily activities in the elderly) in weekly exercise tests. Synchronous scintigraphic study of the cardiac chambers was performed at rest and during exercise prior to and after propranolol use. RESULTS: The reductions in heart rate with the 50 W load and at rest were similar (21% vs 20%; P=0.5100). Propranolol improved the duration of exercise (12.2 +/- 2.0 min vs 13.1 +/- 1.8 min; P=0.0313) and abolished the changes in the ST segment induced by exercise in 8 (57%) patients. At rest, the ejection fraction was not modified by the beta-blocker. During maximum exercise, propranolol reduced the end-systolic volume index and increased ejection fraction. CONCLUSION: The strategy of using beta-blockers to reduce heart rate by 15% with a 50 W load is safe and beneficial in the elderly patient with myocardial ischemia and preserved ventricular function. The dose of beta-blocker used reduced myocardial ischemia and improved tolerance to exercise without hampering ventricular performance during maximum exercise.

Myocardial revascularization in a patient with situs inversus totalis.

We report the case of a patient with dextrocardia and situs inversus totalis associated with obstructive coronariopathy in the anterior and posterior descending arteries, right coronary artery, first diagonal branch and left marginal branch. The patient underwent coronary artery bypass grafting surgery. This surgery has been rarely reported in literature and we found only one similar case in the national medical literature. The myocardial revascularization was carried out with the right mammary artery for the anterior descending artery. The saphenous vein anastomosed the aorta to the right coronary artery, left marginal branch, fist diagonal branch and posterior descending artery. The surgery was performed with extracorporeal circulation.

Predictors of the risk of falls among elderly with chronic atrial fibrillation

OBJECTIVES: Though elderly persons with chronic atrial fibrillation have more comorbidities that could limit indications for the chronic use of anticoagulants, few studies have focused on the risk of falls within this particular group. To evaluate the predictors of the risk of falls among elderly with chronic atrial fibrillation, a cross-sectional, observational study was performed. METHODS: From 295 consecutive patients aged 60 years or older with a history of atrial fibrillation who were enrolled within the last 2 years in the cardiogeriatrics outpatient clinic of the Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, 107 took part in this study. Their age was 77.9±6.4 years, and 62 were female. They were divided into two groups: a) no history of falls in the previous year and b) a history of one or more falls in the previous year. Data regarding the history of falls and social, demographic, anthropometric, and clinical information were collected. Multidimensional assessment instruments and questionnaires were applied. RESULTS: At least one fall was reported in 55 patients (51.4%). Among them, 27 (49.1%) presented recurrent falls, with body lesions in 90.4% and fractures in 9.1% of the cases. Multivariate logistic regression showed that selfreported difficulty maintaining balance, use of amiodarone, and diabetes were independent variables associated with the risk of falls, with a sensitivity of 92.9% and a specificity of 44.9%. CONCLUSION: In a group of elderly patients with chronic atrial fibrillation who were relatively independent and able to attend an outpatient clinic, the occurrence of falls with recurrence and clinical consequences was high. Difficulty maintaining balance, the use of amiodarone and a diagnosis of diabetes mellitus were independent predictors of the risk for falls. Thus, simple clinical data predicted falls better than objective functional tests.

Revascularização do miocárdio em paciente com situs inversus totalis / Myocardial revascularization in a patient with situs inversus totalis

Relatamos o caso de um paciente com situs inversus totalis associado a coronariopatia obstrutiva em artérias descendente anterior e posterior, coronária direita, primeiro ramo diagonal e ramo marginal esquerdo, quadro condizente com a intervenção de revascularização do miocárdio. Esse procedimento não é freqüente na literatura médica, sendo encontrado apenas um relato na literatura brasileira. A revascularização do miocárdio foi realizada com a artéria mamária interna direita para a artéria descendente anterior, e uma ponte de safena para coronária direita, marginal esquerda, primeiro ramo diagonal e descendente posterior. A cirurgia foi realizada com o auxílio de circulação extracorpórea.

We report the case of a patient with dextrocardia and situs inversus totalis associated with obstructive coronariopathy in the anterior and posterior descending arteries, right coronary artery, first diagonal branch and left marginal branch. The patient underwent coronary artery bypass grafting surgery. This surgery has been rarely reported in literature and we found only one similar case in the national medical literature. The myocardial revascularization was carried out with the right mammary artery for the anterior descending artery. The saphenous vein anastomosed the aorta to the right coronary artery, left marginal branch, fist diagonal branch and posterior descending artery. The surgery was performed with extracorporeal circulation.

Teste ergométrico: valor prognóstico em pacientes idosos com doença aterosclerótica coronariana estável / Exercise stress test: prognostic value for elderly patients with stable coronary atherosclerosis

OBJETIVO: Estudar o valor prognóstico das variáveis do teste ergométrico em pacientes idosos com doença aterosclerótica coronariana e isquemia induzida pelo esforço. MÉTODOS: Foram estudados 64 pacientes idosos (61 homens, idade de 73 ± 5 anos) com doença aterosclerótica coronariana, comprovada por coronariografia, clinicamente estável, fração de ejeção de ventrículo esquerdo maior ou igual a 0,40 e isquemia miocárdica durante o teste ergométrico. A cada seis meses, os pacientes foram avaliados para eventos cardíacos (morte, infarto do miocárdio, angina instável, angioplastia e revascularização do miocárdio). RESULTADOS: Após seguimento médio de 48 meses, 23 (36 por cento) pacientes sofreram eventos cardíacos. Não houve diferença clínica e angiográfica entre os pacientes que sofreram o evento e os que não o sofreram. Pela análise multivariada, a presença de dor precordial durante o teste ergométrico (risco relativo de 2,668 e p = 0,031) e a freqüência cardíaca no início da isquemia (risco relativo de 0,966 e p = 0,009) foram associadas a eventos cardíacos. CONCLUSÃO: Nessa população idosa, a presença de dor precordial durante o teste ergométrico e a freqüência cardíaca no início da isquemia foram associadas a eventos cardíacos. Essas variáveis podem ser úteis para avaliação do risco de pacientes com doença aterosclerótica coronariana estável.

Perfíl clínico de idosos portadores de estenose aórtica severa / Clinical Profile of Critical Aortic Stenosis in the Elderly

PURPOSE: To evaluate clinical symptoms and echocardiographic findings in elderly patients with severe aortic stenosis and possible gender differences. METHODS: We studied 54 patients, 24 (44.5) males and 30 (55.5) females aged 80.7 +/- 5.2 years with severe aortic stenosis. The following variables were analyzed: presence of clinical manifestations (dyspnea, angina, and syncope) and echocardiographic indices (left ventricular [LV] dimensions, ejection fraction [EF], and mass index). RESULTS: Dyspnea was the most frequent symptom with overall prevalence of 44. EF was lower than 50in only 2 patients. There were no gender differences in the prevalence of any of the clinical manifestations. Male patients had higher LV volumes (p < 0.05) and lower EF (p = 0.03). CONCLUSION: The data showing dyspnea as the most common clinical manifestation; EF > 50; lower LV volumes and greater EF in female patients suggest that the adaptive mechanisms to this condition may be different between the two sexes.

Fluxo sangüíneo e resistência periférica regionais em idosos portadores de hipertensäo sistólica isolada / Regional blood flow and peripheral resistance in elderly patients with isolated systolic hypertension

Com a finalidade de analisar o comportamento do fluxo e resistência regional em arteríolas da panturrilha de idosos portadores de hipertensäo sistólica isolada, 11 indivíduos, com idades superiores a 65 anos, pressäo sistólica superior a 180 mmHg e diastólica inferior a 90 mmHg, foram submetidos a strain gauge-pletismografia. Eles foram comparados a 2 grupos de voluntários sadios constituídos por 20 jovens e 17 idosos. Foram analisados fluxo de pico, tempo de recuperaçäo e resistência periférica regional. Apesar da resistência periférica ter sido significativamente maior (p <0,05) no grupo de hipertensos (94,8 + 32,4 UI) do que nos jovens (40,4 ñ 15,5 UI) e idosos hígidos (46,0 ñ 18,4 UI), os fluxos e tempo de recuperaçäo foram semelhantes nos três grupos, o que permitiu concluir que houve preservaçäo do mecanismo de autoregulaçäo e da resposta ao estímulo isquêmico nas arteríolas da panturrilha dos idosos portadores de hipertensäo sitólica isolada

Magnésio mononuclear em hipertensos idosos tratados com tiazídico / Mononuclear magnesium in aged hypertensive patients treated with thiazide

Purpose­To study mononuclear magnesium and serum cations (Na, K and Mg) in elderly hypertensive patients treated with hydrochlorothiazide during 90 days. Patients and Methods­ 15 elderly hypertensive patients treated with hydrochlorothiazide, 25 mg/day or placebo. A method of freezing produced total Iysis of the cells; Mg was measured by atomic spectrophotometry. Results­No differences were noted in mononuclear or serum magnesium in the thiazide or placebo treated patients, and the diuretic produced significant decreases in supine systolic and diastolic blood pressure. Conclusion­Magnesium supplementation does not seem essencial in most patients in this conditions

Relaçäo entre os comportamentos das dispersões da onda P e o intervalo QT em idosos com insuficiência cardíaca / Relation between the behaviors of P-wave and QT dispersions in elderly patients with heart failure

OBJECTIVE - To assess the relation between P-wave and QT dispersions in elderly patients with heart failure. METHODS - Forty-seven elderly patients (75.6±6 years) with stable heart failure in NYHA functional classes II or III and with ejection fractions of 37±6 percent underwent body surface mapping to analyze P-wave and QT dispersions. The degree of correlation between P-wave and QT dispersions was assessed, and P-wave dispersion values in patients with QT dispersion greater than and smaller than 100 ms were compared. RESULTS - The mean values of P-wave and QT dispersions were 54±14 ms and 68±27 ms, respectively. The correlation between the 2 variables was R=0.41 (p=0.04). In patients with QT dispersion values > 100 ms, P-wave dispersion was significantly greater than in those with QT dispersion values < 100 ms (58±16 vs 53±12 ms, p=0.04 ). CONCLUSION - Our results suggest that, in elderly patients with heart failure, a correlation between the values of P-wave and QT dispersions exists. These findings may have etiopathogenic, pathophysiologic, prognostic, and therapeutic implications, which should be investigated in other studies

Estratégia para individualizar uma dose eficiente de betabloqueador em pacientes idosos com isquemia miocárdica e função ventricular esquerda preservada / Strategy for identifying an efficient dosage of beta-blocker for elderly patients with myocardial ischemia and preserved left ventricular function

OBJETIVO: Avaliar estratégia de titulação para prescrever uma dose de propranolol que seria eficiente em reduzir isquemia do miocárdio em idosos. MÉTODOS: Foram estudados 14 homens idosos (73,6 ± 5,3 anos), portadores de doença coronariana estável, documentada pela cinecoronariografia, com resposta isquêmica ao teste ergométrico e função ventricular esquerda preservada. O propranolol foi titulado a fim de atingir redução de 15 por cento na freqüência cardíaca, ao final da carga de 50 W (correspondente às atividades diárias normais de idosos), em testes ergométricos semanais e feito estudo cintilográfico sincronizado das câmaras cardíacas, em repouso e durante exercício, antes e após seu uso. RESULTADOS: As reduções da freqüência cardíaca na carga de 50 W e em repouso foram semelhantes (21 por cento vs 20 por cento; p=0,5100). O propranolol melhorou a duração do exercício (12,2 ± 2,0 min vs 13,1 ± 1,8 min; p=0,0313) e aboliu as alterações do segmento ST induzidas pelo exercício em 8 (57 por cento) pacientes. Em repouso, a fração de ejeção não foi modificada pelo betabloqueador. Durante o exercício máximo, o propranolol reduziu o índice de volume sistólico final e aumentou a fração de ejeção. CONCLUSAO: A estratégia de empregar betabloqueadores para reduzir a freqüência cardíaca em 15 por cento na carga de 50 W é segura e benéfica nos idosos com isquemia miocárdica e função ventricular preservada. A dose utilizada reduziu a isquemia miocárdica e melhorou a tolerância ao exercício, sem prejudicar o desempenho ventricular durante exercício máximo.

Comparaçäo entre os efeitos da clortalidona e do diltiazem sobre a isquemia miocárdica em idosos hipertensos portadores de doença arterial coronariana / Effects of chlorthalidone and diltiazem on myocardial ischemia in elderly patients with hypertension and coronary artery disease

OBJECTIVE: Antihypertensive therapy with thiazides decreases coronary events in elderly patients. However, the influence of diuretics on myocardial ischemia has not been fully investigated. The aim of this study was to compare the effect of chlorthalidone and diltiazem on myocardial ischemia. METHODS: Following a randomized, double-blind, crossover protocol, we studied 15 elderly hypertensive patients aged 73.6 + or - 4.6 years with myocardial ischemia. All patients had angiographically documented coronary artery disease. We measured patients using 48- hour ambulatory electrocardiogram monitoring and exercise testing. After a 2-week period using placebo, patients received chlorthalidone or diltiazem for 4 weeks. RESULTS: Both treatments lowered systolic and diastolic blood pressures...

Magnésio linfocitário e sérico em idosos sadios e hipertensos / Lymphocyte and serum magnesium in older healthy and hypertensive subjects

Estudo do magnésio (Mg) linfocitário e sérico em idosos com e sem hipertensäo arterial. Vinte e dois hipertensos idosos e 12 idosos normotensos, bem como grupo controle composto de 11 doadores de sangue voluntários jovens. Os linfócitos do sangue periférico foram isolados, separando por gradiente de densidade em meio de Ficoll 400-metrizoato de sódio. O congelamento em "freezer" produziu lise total das células, permitindo a dosagem da concentraçäo de Mg por célula. A relaçäo entre o Mg linfocitário dos hipertensos idosos dividido pelo valor obtido nos controles foi 1,49. A relaçäo entre o Mg linfocitário dos normotensos idosos dividido pelos controles foi 1,70. O Mg sérico dos idosos normotensos foi 1,63 ñ 0,12, o dos idoso hipertensos foi 1,48 ñ 0,14 e o do grupo controle foi 1,44 ñ 0,12 (valores em mEq/l). Os idosos hipertensos e normotensos apresentam níveis mais elevados de Mg linfocitário e sérico que os controles jovens. Questiona-se a validade de se propor a suplementaçäo de Mg ou diuréticos retentores do cation para os idosos hipertensos

Purpose­To studg the Igmphoeyte and serum magnesium in old er patients with and without arterial hypertension. Patients and Methods­We studied the Iymphocyte and serum Mg in 22 older patients, with diastolic blood pressure between 95 and 120 mmHg, not receiving drug treatment. A method offreezing produced total Iysis of the cells. Results­The mean Iymphocyte Mg concentration in the older patients was 1.15 + 0.74 picomoles per 100 cells, signif cantly higher (p < 0.05) than in the control group, that was 0.77 + 0.32 picomoles per 100 cells (Iymphocyte Mg in older hypertensive patientslcontrol = 1.49); there were no signiJicant differences between groups with regard to serum Mg. Twelve older normotensive men studied also had Iymphocyte Mg signif cantly higher than in the respective control group (Iymphocyte Mg in old er normotensive menl control = 1.70) and the serum Mg was also signifcantly higher than in the control group (1.63 + 0.12 versus 1.44 0.22 mEq/l). Conclusion­Since the high intracellular Mg concentration in the elderly patients may more accurately refect the total body Mg status. We suggest to use Mg and Mg sparing diuretics in these patients, both hypertensive and normotensive, cautiously

Influência de betabloqueadores com atividade simpaticomimética intrínseca sobre pressäo arterial e lípides sanguíneos em portadores de hipertensäo arterial essencial / Effect of beta blockers with intrinsic sympathomimetic activity on blood pressure and blood lipids in patients with essential hypertension

Com a finalidade do comparar os efeitos de um betabloqueador com atividade simpaticomimética intrínseca (ASI) aos de um sem ASI, foram selecionados hipertensos com idade superior a 50 anos estudados durante quatro semanas e compreendendo três grupos: A) mepindolol (com ASI) 5mg/dia, 10 pacientes; B) metoprolol "duriles" (sem ASI) 200 mg/dia, 9 pacientes; C) placebo, 10 pacientes. Realizaram-se avaliaçäo clínica, prova ergométrica e dosagem de lípides sangüíneos antes e após o tratamento. O estudo da influência das drogas foi realizado pela análise de perfil. Em repouso, as três substâncias administradas reduziram igualmente a pressäo sistólica (PS), pressäo diastólica (PD) e freqüência cardíaca (FC). As médias de PS, PD e FC, em repouso, pós-tratamento foram respectivamente: 154,0, 95,5, 73,7 (grupo A); 148,8, 94,4, 70,1 (grupo B); 153,0, 96,0, 77,8 (grupo C). Na prova ergométrica houve reduçäo da PS, FC e duplo produto (DP) nos três grupos. A PD näo sofreu influência das drogas. As médias de PS, PD, FC e DP na carga máxima comum para os três grupos, na fase pós-tratamento, foram respectivamente: 198,0, 115,5, 124,3, 246,9 (grupo A); 198,8, 114,4, 144,6, 283,2 (grupo B); 202,2, 119,0, 143,5, 283,4 (grupo C). Em relaçäo ao perfil lipídico houve apenas uma discreta elevaçäo dos níveis séricos de triglicérides e de VLDL-colesterol após o tratamento. Em concluäo, o emprego do mepindolol e do metroprolol "duriles" foi igualmente útil na reduçäo dos níveis de pressäo arterial de hipertensos...

Abordagem das hipotensões ortostática / Management of orthostatic and postprandial hypotension

A prevalência de hipotensão ortostática e pós-prandial é elevada na população idosa, estando muito associado à disautonomia. As manifestações clínicas variam de sintomas inespecíficos e tontura até casos de síncope acompanhados de trauma. O diagnóstico é clínico, estabelecido por meio de anamnese detalhada e exame físico. Monitorização ambulatorial da pressão arterial (MAPA) e tilt-test são complementares em situações específicas. O tratamento é feito com base em medidas como suspensão de medicamentos hipotensores, cuidados posturais e relacionados à ingestão alimentar. A droga de escolha é a fludrocortisona, um esteróide adrenocortical com propriedades mineralocorticóides. Agentes simpaticomiméticos são uma segunda opção. A individualização de condutas é essencial, uma vez que a presença de comorbidades limita o emprego de determinadas diretrizes.

Anticoagulação no idoso / Anticoagulants in older patients

A demografia e a epidemiologia demonstram a necessidade de aprimorar a terapêutica das doenças cardiovasculares na crescente população idosa. A heterogeneidade é uma característica do envelhecimento, principalmente pela presença de co-morbidade, que têm importante influência no tratamento das doenças do idoso. A farmacoterapia adequada para o paciente idoso requer conhecimento especial das propriedades farmacológicas das drogas, assim como compreensão dos aspectos clínicos, epidemiológicos, socioculturais e econòmicos. Os anticoagulantes de , alto risco, e exigem atenção especial, quando utilizados.

Fibrilacao atrial no idoso / Atrial fibrillation in the elderly

A fibrilacao atrial relaciona-se a maior incidencia de embolia arterial e sua prevalencia aumenta com o envelhecimento. Na avaliacao do idoso com fibrilacao atrial e importante pesquisar possiveis etiologias cardiacas ou extracardiacas. A anticoagulacao e benefica, pois reduz a incidencia de embolias arteriais. Os controles clinicos e laboratorial devem ser mais frequentes para reduzir a incidencia de complicacoes hemorragicas.