Detalhe da pesquisa
1.
The Combination Treatment of Fosmanogepix and Liposomal Amphotericin B Is Superior to Monotherapy in Treating Experimental Invasive Mold Infections.
Antimicrob Agents Chemother
; 66(7): e0038022, 2022 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35670592
2.
Efficacy and Pharmacokinetics of Fosmanogepix (APX001) in the Treatment of Candida Endophthalmitis and Hematogenous Meningoencephalitis in Nonneutropenic Rabbits.
Antimicrob Agents Chemother
; 65(3)2021 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33361304
3.
Therapeutic Potential of Fosmanogepix (APX001) for Intra-abdominal Candidiasis: from Lesion Penetration to Efficacy in a Mouse Model.
Antimicrob Agents Chemother
; 65(4)2021 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33468476
4.
In Vitro Activity of APX2041, a New Gwt1 Inhibitor, and In Vivo Efficacy of the Prodrug APX2104 against Aspergillus fumigatus.
Antimicrob Agents Chemother
; 65(10): e0068221, 2021 09 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34310205
5.
In Vitro Activity of Manogepix against Multidrug-Resistant and Panresistant Candida auris from the New York Outbreak.
Antimicrob Agents Chemother
; 64(11)2020 10 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32839219
6.
Enhanced Efflux Pump Expression in Candida Mutants Results in Decreased Manogepix Susceptibility.
Antimicrob Agents Chemother
; 64(5)2020 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32179530
7.
Fosmanogepix (APX001) Is Effective in the Treatment of Pulmonary Murine Mucormycosis Due to Rhizopus arrhizus.
Antimicrob Agents Chemother
; 64(6)2020 05 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32205345
8.
Evaluation of Resistance Development to the Gwt1 Inhibitor Manogepix (APX001A) in Candida Species.
Antimicrob Agents Chemother
; 64(1)2019 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31611349
9.
Galactomannan Is a Biomarker of Fosmanogepix (APX001) Efficacy in Treating Experimental Invasive Pulmonary Aspergillosis.
Antimicrob Agents Chemother
; 64(1)2019 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31685475
10.
APX001 and Other Gwt1 Inhibitor Prodrugs Are Effective in Experimental Coccidioides immitis Pneumonia.
Antimicrob Agents Chemother
; 63(2)2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30455238
11.
Synthesis of analogs of the Gwt1 inhibitor manogepix (APX001A) and in vitro evaluation against Cryptococcus spp.
Bioorg Med Chem Lett
; 29(23): 126713, 2019 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31668974
12.
Significantly Improved Pharmacokinetics Enhances In Vivo Efficacy of APX001 against Echinocandin- and Multidrug-Resistant Candida Isolates in a Mouse Model of Invasive Candidiasis.
Antimicrob Agents Chemother
; 62(10)2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30012766
13.
In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus.
Antimicrob Agents Chemother
; 62(8)2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29891599
14.
Tedizolid for the management of human infections: in vitro characteristics.
Clin Infect Dis
; 58 Suppl 1: S35-42, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24343830
15.
Genetic environment and stability of cfr in methicillin-resistant Staphylococcus aureus CM05.
Antimicrob Agents Chemother
; 56(1): 332-40, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22024827
16.
GR-2397: Review of the Novel Siderophore-like Antifungal Agent for the Treatment of Invasive Aspergillosis.
J Fungi (Basel)
; 8(9)2022 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36135634
17.
Efficacy of APX2039 in a Rabbit Model of Cryptococcal Meningitis.
mBio
; 13(6): e0234722, 2022 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36222509
18.
Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3.
Antimicrob Agents Chemother
; 54(12): 5352-5, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20837755
19.
Structure-activity relationships of diverse oxazolidinones for linezolid-resistant Staphylococcus aureus strains possessing the cfr methyltransferase gene or ribosomal mutations.
Antimicrob Agents Chemother
; 54(12): 5337-43, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20837751
20.
Fosmanogepix: A Review of the First-in-Class Broad Spectrum Agent for the Treatment of Invasive Fungal Infections.
J Fungi (Basel)
; 6(4)2020 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33105672