Pesquisa | BVS Integralidade em Saúde

1.

Lipid-Reduction Variability and Antidrug-Antibody Formation with Bococizumab.

Ridker, Paul M; Tardif, Jean-Claude; Amarenco, Pierre; Duggan, William; Glynn, Robert J; Jukema, J Wouter; Kastelein, John J P; Kim, Albert M; Koenig, Wolfgang; Nissen, Steven; Revkin, James; Rose, Lynda M; Santos, Raul D; Schwartz, Pamela F; Shear, Charles L; Yunis, Carla.

N Engl J Med ; 376(16): 1517-1526, 2017 04 20.

Artigo em Inglês | MEDLINE | ID: mdl-28304227

2.

Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients.

Ridker, Paul M; Revkin, James; Amarenco, Pierre; Brunell, Robert; Curto, Madelyn; Civeira, Fernando; Flather, Marcus; Glynn, Robert J; Gregoire, Jean; Jukema, J Wouter; Karpov, Yuri; Kastelein, John J P; Koenig, Wolfgang; Lorenzatti, Alberto; Manga, Pravin; Masiukiewicz, Urszula; Miller, Michael; Mosterd, Arend; Murin, Jan; Nicolau, Jose C; Nissen, Steven; Ponikowski, Piotr; Santos, Raul D; Schwartz, Pamela F; Soran, Handrean; White, Harvey; Wright, R Scott; Vrablik, Michal; Yunis, Carla; Shear, Charles L; Tardif, Jean-Claude.

N Engl J Med ; 376(16): 1527-1539, 2017 04 20.

Artigo em Inglês | MEDLINE | ID: mdl-28304242

3.

CSL112 enhances biomarkers of reverse cholesterol transport after single and multiple infusions in healthy subjects.

Gille, Andreas; Easton, Rachael; D'Andrea, Denise; Wright, Samuel D; Shear, Charles L.

Arterioscler Thromb Vasc Biol ; 34(9): 2106-14, 2014 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-24969776

4.

Relationship between atorvastatin dose and the harm caused by torcetrapib.

Barter, Philip J; Rye, Kerry-Anne; Beltangady, Mohan S; Ports, William C; Duggan, William T; Boekholdt, S Matthijs; DeMicco, David A; Kastelein, John J P; Shear, Charles L.

J Lipid Res ; 53(11): 2436-42, 2012 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-22941786

5.

Effect of torcetrapib on the progression of coronary atherosclerosis.

Nissen, Steven E; Tardif, Jean-Claude; Nicholls, Stephen J; Revkin, James H; Shear, Charles L; Duggan, William T; Ruzyllo, Witold; Bachinsky, William B; Lasala, Gabriel P; Lasala, Gregory P; Tuzcu, E Murat.

N Engl J Med ; 356(13): 1304-16, 2007 Mar 29.

Artigo em Inglês | MEDLINE | ID: mdl-17387129

6.

Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia.

Kastelein, John J P; van Leuven, Sander I; Burgess, Leslie; Evans, Greg W; Kuivenhoven, Jan A; Barter, Philip J; Revkin, James H; Grobbee, Diederick E; Riley, Ward A; Shear, Charles L; Duggan, William T; Bots, Michiel L.

N Engl J Med ; 356(16): 1620-30, 2007 Apr 19.

Artigo em Inglês | MEDLINE | ID: mdl-17387131

7.

Effects of torcetrapib in patients at high risk for coronary events.

Barter, Philip J; Caulfield, Mark; Eriksson, Mats; Grundy, Scott M; Kastelein, John J P; Komajda, Michel; Lopez-Sendon, Jose; Mosca, Lori; Tardif, Jean-Claude; Waters, David D; Shear, Charles L; Revkin, James H; Buhr, Kevin A; Fisher, Marian R; Tall, Alan R; Brewer, Bryan.

N Engl J Med ; 357(21): 2109-22, 2007 Nov 22.

Artigo em Inglês | MEDLINE | ID: mdl-17984165

8.

Inhibition of CETP by torcetrapib attenuates the atherogenicity of postprandial TG-rich lipoproteins in type IIB hyperlipidemia.

Guerin, Maryse; Le Goff, Wilfried; Duchene, Emilie; Julia, Zélie; Nguyen, Tu; Thuren, Tom; Shear, Charles L; Chapman, M John.

Arterioscler Thromb Vasc Biol ; 28(1): 148-54, 2008 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-17951324

9.

Assessing the Potential Risk of Cross-Reactivity Between Anti-Bococizumab Antibodies and Other Anti-PCSK9 Monoclonal Antibodies.

Wang, Ellen Q; Bukowski, Jack F; Yunis, Carla; Shear, Charles L; Ridker, Paul M; Schwartz, Pamela F; Baltrukonis, Daniel.

BioDrugs ; 33(5): 571-579, 2019 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-31529318

10.

Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia (RADIANCE 2 study): a randomised, double-blind trial.

Bots, Michiel L; Visseren, Frank L; Evans, Gregory W; Riley, Ward A; Revkin, James H; Tegeler, Charles H; Shear, Charles L; Duggan, William T; Vicari, Ralph M; Grobbee, Diederick E; Kastelein, John J.

Lancet ; 370(9582): 153-160, 2007 Jul 14.

Artigo em Inglês | MEDLINE | ID: mdl-17630038

11.

Inhibition of cholesteryl ester transfer protein by torcetrapib modestly increases macrophage cholesterol efflux to HDL.

Yvan-Charvet, Laurent; Matsuura, Fumihiko; Wang, Nan; Bamberger, Mark J; Nguyen, Tu; Rinninger, Franz; Jiang, Xian-Cheng; Shear, Charles L; Tall, Alan R.

Arterioscler Thromb Vasc Biol ; 27(5): 1132-8, 2007 May.

Artigo em Inglês | MEDLINE | ID: mdl-17322101

12.

Cardiovascular event reduction with PCSK9 inhibition among 1578 patients with familial hypercholesterolemia: Results from the SPIRE randomized trials of bococizumab.

Ridker, Paul M; Rose, Lynda M; Kastelein, John J P; Santos, Raul D; Wei, Caimiao; Revkin, James; Yunis, Carla; Tardif, Jean-Claude; Shear, Charles L.

J Clin Lipidol ; 12(4): 958-965, 2018.

Artigo em Inglês | MEDLINE | ID: mdl-29685591

13.

Infusion of Reconstituted High-Density Lipoprotein, CSL112, in Patients With Atherosclerosis: Safety and Pharmacokinetic Results From a Phase 2a Randomized Clinical Trial.

Tricoci, Pierluigi; D'Andrea, Denise M; Gurbel, Paul A; Yao, Zhenling; Cuchel, Marina; Winston, Brion; Schott, Robert; Weiss, Robert; Blazing, Michael A; Cannon, Louis; Bailey, Alison; Angiolillo, Dominick J; Gille, Andreas; Shear, Charles L; Wright, Samuel D; Alexander, John H.

J Am Heart Assoc ; 4(8): e002171, 2015 Aug 25.

Artigo em Inglês | MEDLINE | ID: mdl-26307570

14.

Torcetrapib and atorvastatin.

Shear, Charles L.

N Engl J Med ; 353(14): 1527-9; author reply 1527-9, 2005 Oct 06.

Artigo em Inglês | MEDLINE | ID: mdl-16207861

15.

Ultrasound protocols to measure carotid intima-media thickness in trials; comparison of reproducibility, rate of progression, and effect of intervention in subjects with familial hypercholesterolemia and subjects with mixed dyslipidemia.

Dogan, Soner; Duivenvoorden, Raphaël; Grobbee, Diederick E; Kastelein, John J P; Shear, Charles L; Evans, Greg W; Visseren, Frank L; Bots, Michiel L.

Ann Med ; 42(6): 447-64, 2010 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-20645885

16.

Completeness of carotid intima media thickness measurements depends on body composition: the RADIANCE 1 and 2 trials.

Dogan, Soner; Duivenvoorden, Raphaël; Grobbee, Diederick E; Kastelein, John J P; Shear, Charles L; Evans, Gregory W; Visseren, Frank L; Bots, Michiel L.

J Atheroscler Thromb ; 17(5): 526-35, 2010 May.

Artigo em Inglês | MEDLINE | ID: mdl-20228610

17.

Biomarkers in the prevention and treatment of atherosclerosis: need, validation, and future.

Revkin, James H; Shear, Charles L; Pouleur, Hubert G; Ryder, Steven W; Orloff, David G.

Pharmacol Rev ; 59(1): 40-53, 2007 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-17329547

18.

Designs of RADIANCE 1 and 2: carotid ultrasound studies comparing the effects of torcetrapib/atorvastatin with atorvastatin alone on atherosclerosis.

Kastelein, John J P; van Leuven, Sander I; Evans, Gregory W; Riley, Ward A; Revkin, James H; Shear, Charles L; Bots, Michiel L.

Curr Med Res Opin ; 23(4): 885-94, 2007 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-17407645

19.

Efficacy and safety of torcetrapib, a novel cholesteryl ester transfer protein inhibitor, in individuals with below-average high-density lipoprotein cholesterol levels.

Davidson, Michael H; McKenney, James M; Shear, Charles L; Revkin, James H.

J Am Coll Cardiol ; 48(9): 1774-81, 2006 Nov 07.

Artigo em Inglês | MEDLINE | ID: mdl-17084249

20.

Efficacy and safety of torcetrapib, a novel cholesteryl ester transfer protein inhibitor, in individuals with below-average high-density lipoprotein cholesterol levels on a background of atorvastatin.

McKenney, James M; Davidson, Michael H; Shear, Charles L; Revkin, James H.

J Am Coll Cardiol ; 48(9): 1782-90, 2006 Nov 07.

Artigo em Inglês | MEDLINE | ID: mdl-17084250

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