Detalhe da pesquisa
1.
Translatability of In Vitro Stress for Predicting Deamidation and Oxidation Biotransformation on Biotherapeutics.
Anal Chem
; 95(49): 17957-17961, 2023 12 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38084380
2.
Improving priors for human monoclonal antibody linear pharmacokinetic parameters by using half-lives from non-human primates.
J Pharmacokinet Pharmacodyn
; 48(2): 295-303, 2021 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-33389522
3.
Parameterisation affects identifiability of population models.
J Pharmacokinet Pharmacodyn
; 41(1): 81-6, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24378914
4.
Preclinical and translational pharmacology of afucosylated anti-CCR8 antibody for depletion of tumour-infiltrating regulatory T cells.
Br J Pharmacol
; 181(13): 2033-2052, 2024 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-38486310
5.
Complex PK-PD of an engineered IL-15/IL-15Rα-Fc fusion protein in cynomolgus monkeys: QSP modeling of lymphocyte dynamics.
Eur J Pharm Sci
; 186: 106450, 2023 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37084985
6.
Evolution of preclinical characterization and insights into clinical pharmacology of checkpoint inhibitors approved for cancer immunotherapy.
Clin Transl Sci
; 15(8): 1818-1837, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35588531
7.
Novel Anti-LY6G6D/CD3 T-Cell-Dependent Bispecific Antibody for the Treatment of Colorectal Cancer.
Mol Cancer Ther
; 21(6): 974-985, 2022 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35364611
8.
Direct Tie2 Agonists Stabilize Vasculature for the Treatment of Diabetic Macular Edema.
Transl Vis Sci Technol
; 11(10): 27, 2022 10 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36255358
9.
Antibody Format and Serum Disposition Govern Ocular Pharmacokinetics of Intravenously Administered Protein Therapeutics.
Front Pharmacol
; 12: 601569, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34025395
10.
In Vivo Reoxidation Kinetics of Free Thiols in Multiple Domains of IgG1 Antibodies in Rats.
J Pharm Sci
; 110(5): 1989-1996, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33617870
11.
An In Silico Knockout Model for Gastrointestinal Absorption Using a Systems Pharmacology Approach - Development and Application for Ketones.
PLoS One
; 11(9): e0163795, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27685985
12.
The Population Pharmacokinetics of D-ß-hydroxybutyrate Following Administration of (R)-3-Hydroxybutyl (R)-3-Hydroxybutyrate.
AAPS J
; 18(3): 678-88, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26893218
13.
Species difference in the in vitro and in vivo metabolism of amtolmetin guacil.
Arzneimittelforschung
; 60(11): 667-74, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-21175039