Detalhe da pesquisa
1.
Programming inactive RNA-binding small molecules into bioactive degraders.
Nature
; 618(7963): 169-179, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-37225982
2.
Profiling Cellular Morphological Changes Induced by Dual-targeting PROTACs of Aurora Kinase and RNA-binding Protein YTHDF2.
Chembiochem
; : e202400183, 2024 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38837838
3.
Collective Synthesis of Sarpagine and Macroline Alkaloid-Inspired Compounds.
Chemistry
; 30(5): e202303027, 2024 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37755456
4.
Fluorescent probes and degraders of the sterol transport protein Aster-A.
Bioorg Med Chem
; 103: 117673, 2024 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38518734
5.
Tafbromin selectively targets the TAF1 bromodomain.
Angew Chem Int Ed Engl
; : e202404645, 2024 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38801173
6.
Identification of Biologically Diverse Tetrahydronaphthalen-2-ols through the Synthesis and Phenotypic Profiling of Chemically Diverse, Estradiol-Inspired Compounds.
Chembiochem
; 24(5): e202200555, 2023 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36594441
7.
Inducin Triggers LC3-Lipidation and ESCRT-Mediated Lysosomal Membrane Repair.
Chembiochem
; 24(24): e202300579, 2023 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37869939
8.
Scaffold Remodelling of Diazaspirotricycles Enables Synthesis of Diverse sp3 -Rich Compounds With Distinct Phenotypic Effects.
Chemistry
; 29(26): e202203992, 2023 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36722618
9.
Synthetic Matching of Complex Monoterpene Indole Alkaloid Chemical Space.
Angew Chem Int Ed Engl
; 62(48): e202310222, 2023 11 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37818743
10.
Polyether Cyclization Cascade Alterations in Response to Monensin Polyketide Synthase Mutations.
Chembiochem
; 23(2): e202100584, 2022 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34729883
11.
Identification of Dihydroorotate Dehydrogenase Inhibitors Using the Cell Painting Assay.
Chembiochem
; 23(22): e202200475, 2022 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36134475
12.
Unprecedented Combination of Polyketide Natural Product Fragments Identifies the New Hedgehog Signaling Pathway Inhibitor Grismonone.
Chemistry
; 28(67): e202202164, 2022 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36083197
13.
Synthesis and evaluation of RNase L-binding 2-aminothiophenes as anticancer agents.
Bioorg Med Chem
; 58: 116653, 2022 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35152173
14.
Synthesis of 20-Membered Macrocyclic Pseudo-Natural Products Yields Inducers of LC3 Lipidation.
Angew Chem Int Ed Engl
; 61(11): e202114328, 2022 03 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34978373
15.
Identification of a Novel Pseudo-Natural Product Type IV IDO1 Inhibitor Chemotype.
Angew Chem Int Ed Engl
; 61(40): e202209374, 2022 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35959923
16.
Combination of Pseudo-Natural Product Design and Formal Natural Product Ring Distortion Yields Stereochemically and Biologically Diverse Pseudo-Sesquiterpenoid Alkaloids.
Angew Chem Int Ed Engl
; 60(39): 21384-21395, 2021 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34297473
17.
Design, Synthesis, and Biological Evaluation of Chemically and Biologically Diverse Pyrroquinoline Pseudo Natural Products.
Angew Chem Int Ed Engl
; 60(9): 4648-4656, 2021 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33200868
18.
Cell-Based Identification of New IDO1 Modulator Chemotypes.
Angew Chem Int Ed Engl
; 60(18): 9869-9874, 2021 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33565680
19.
Morphological Profiling Identifies a Common Mode of Action for Small Molecules with Different Targets.
Chembiochem
; 21(22): 3197-3207, 2020 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32618075
20.
Image-Based Morphological Profiling Identifies a Lysosomotropic, Iron-Sequestering Autophagy Inhibitor.
Angew Chem Int Ed Engl
; 59(14): 5721-5729, 2020 03 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31769920