Detalhe da pesquisa
1.
Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.
Cell
; 161(6): 1252-65, 2015 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26046436
2.
High-Throughput Screening to Advance In Vitro Toxicology: Accomplishments, Challenges, and Future Directions.
Annu Rev Pharmacol Toxicol
; 64: 191-209, 2024 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37506331
3.
Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators.
Proc Natl Acad Sci U S A
; 120(25): e2218896120, 2023 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37327313
4.
A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion.
Biochem Biophys Res Commun
; 718: 149981, 2024 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38735134
5.
A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cells.
Nat Methods
; 18(5): 528-541, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33941937
6.
A quantitative high-throughput screen identifies compounds that lower expression of the SCA2-and ALS-associated gene ATXN2.
J Biol Chem
; 298(8): 102228, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35787375
7.
Novel Transmission-Blocking Antimalarials Identified by High-Throughput Screening of Plasmodium berghei Ookluc.
Antimicrob Agents Chemother
; 67(4): e0146522, 2023 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36856421
8.
Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells.
Biochem Biophys Res Commun
; 679: 116-121, 2023 Oct 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37683456
9.
In vitro profiling of pesticides within the Tox21 10K compound library for bioactivity and potential toxicity.
Toxicol Appl Pharmacol
; 473: 116600, 2023 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37321325
10.
Predictive Models for Human Cytochrome P450 3A7 Selective Inhibitors and Substrates.
J Chem Inf Model
; 63(3): 846-855, 2023 02 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36719788
11.
TCRD and Pharos 2021: mining the human proteome for disease biology.
Nucleic Acids Res
; 49(D1): D1334-D1346, 2021 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33156327
12.
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Proc Natl Acad Sci U S A
; 117(49): 31365-31375, 2020 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33229545
13.
The AKT modulator A-443654 reduces α-synuclein expression and normalizes ER stress and autophagy.
J Biol Chem
; 297(4): 101191, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34520759
14.
Controlled Proteolysis of an Essential Virulence Determinant Dictates Infectivity of Lyme Disease Pathogens.
Infect Immun
; 90(5): e0005922, 2022 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35416705
15.
Prediction of drug-induced liver injury and cardiotoxicity using chemical structure and in vitro assay data.
Toxicol Appl Pharmacol
; 454: 116250, 2022 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36150479
16.
Synergistic and Antagonistic Drug Combinations against SARS-CoV-2.
Mol Ther
; 29(2): 873-885, 2021 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33333292
17.
Identification of environmental chemicals that activate p53 signaling after in vitro metabolic activation.
Arch Toxicol
; 96(7): 1975-1987, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35435491
18.
Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays.
J Biol Chem
; 295(12): 4001-4013, 2020 03 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32034092
19.
A Universal and High-Throughput Proteomics Sample Preparation Platform.
Anal Chem
; 93(24): 8423-8431, 2021 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34110797
20.
Development of Robust Quantitative Structure-Activity Relationship Models for CYP2C9, CYP2D6, and CYP3A4 Catalysis and Inhibition.
Drug Metab Dispos
; 49(9): 822-832, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34183376