Cobalt-Induced Phase Transformation of Ni3Ga4 Generates Chiral Intermetallic Co3Ni3Ga8.

The scientific community has found immense difficulty to focus on the generation of chiral intermetallics compared to the chiral molecular structure, probably due to the technical difficulty in producing them as no general controlled protocol is available. Herein, using a conventional metal flux technique, we have discovered a new ternary intermetallic Co3Ni3Ga8, substituting Co at the Ni sublattice in a highly symmetric Ni3Ga4 (Ia3̅d). Co3Ni3Ga8 crystallizes in the I4132 space group, a Sohncke type, and can host the chiral structure. To the best of our knowledge, this is the first report of a ternary intermetallic crystallizing in this space group. The chiral structure of Co3Ni3Ga8 is comprehensively mapped by various techniques such as single-crystal X-ray diffraction (XRD), synchrotron powder XRD, X-ray absorption spectroscopy (XAS), scanning transmission electron microscopy (STEM) and theoretically studied using density functional theory. The discovery of this chiral compound can inspire the researchers to design hidden ternary chiral intermetallics to study the exotic electrical and magnetic properties.

Does BRAF mutation status and related clinicopathological factors affect the recurrence rate of ameloblastoma? A systematic review, meta-analysis and metaregression.

OBJECTIVES: This review aims to analyse the recurrence rate in BRAFv600e+ and BRAFv600e- ameloblastomas and explore its association with clinicopathological variables. METHODS: A comprehensive search was conducted using databases including PubMed, Embase, Cochrane Central Register of Controlled Trials, Clinicaltrials.gov, Google Scholar and grey literature, without any limitation on start date or language up to 20 June 2023. A random effect meta-analysis was conducted and Metaregression analyses were performed based on available clinicopathological factors. RESULTS: Fifteen studies met the criteria for meta-analysis of outcomes. There was no significant difference in overall recurrence rates between the two groups (risk difference = 0.001, p-value = 0.987). Increasing male:female ratio in the BRAFv600e+ group was associated with a lower reported recurrence, suggesting a higher recurrence rate in females. The odds of having mandibular lesion were four times higher in BRAFv600e+ cases compared to BRAFv600e- cases (confidence interval: 2.121-7.870, p < 0.001, I2 = 28.37%). CONCLUSION: Within the BRAFv600e+ group, females showed a higher reported recurrence rate. This specific clinical group may benefit from BRAFv600e mutation investigation and potential upscaled surgical treatment and additional BRAF inhibitor therapy, which needs validation in future studies.

Validation study of new clinical scoring - "Apollo Clinical Scoring system" for bladder pain syndrome/interstitial cystitis and comparison of outcome with standard "O'Leary-Sant score".

AIM: Validation of the recently published newer clinical scoring system for bladder pain syndrome/interstitial cystitis and comparison of the results with the pre-existing standard O'Leary-Sant score. INTRODUCTION: The symptoms are our primary guide to disease severity analysis, treatment, and response monitoring. The combined ICSI/ICPI (O'Leary-Sant Interstitial Cystitis Symptom and Problem Index) consist of a four-item symptom and problem index focusing on urgency, frequency, nocturia, and pain. A new scale, assigning more weight to pain and nocturia and adding the domains of sexual dysfunction and psychological impact, has been published by one of the authors (El Khoudary et al. J Women's Health 2002. 18:1361-1368; 7). MATERIAL AND METHODS: This is a prospective study conducted to validate a newer clinical scoring system, namedht e 'Apollo Clinical Scoring' (ACS) system for patients with bladder pain syndrome/ interstitial cystitis (BPS/IC), and to compare its outcome with the simultaneously applied standard O'Leary-Sant (OLS) score. Thirty-five patients of BPS/IC diagnosed using the ESSIC definition were enrolled in the study and followed for 6 months. Intraclass correlation coefficient (ICC) for test-retest reliability, and Cronbach's α for measure of internal consistency, were applied to both scoring systems. RESULTS: Intraclass correlation coefficient for ACS was 0.715 and for OLS was 0.689. Cronbach's α for ACS was 0.736 and for OLS was 0.698. CONCLUSION: The present study suggests that the recently devised Apollo Clinical Scoring (ACS) system for patients of BPS/IC is internally consistent and a reliable scoring system. When compared with OLS in parallel setting, the newer ACS appeared to be marginally better.

Wurtzite CuGaS2 with an In-Situ-Formed CuO Layer Photocatalyzes CO2 Conversion to Ethylene with High Selectivity.

We present surface reconstruction-induced C-C coupling whereby CO2 is converted into ethylene. The wurtzite phase of CuGaS2. undergoes in situ surface reconstruction, leading to the formation of a thin CuO layer over the pristine catalyst, which facilitates selective conversion of CO2 to ethylene (C2 H4 ). Upon illumination, the catalyst efficiently converts CO2 to C2 H4 with 75.1 % selectivity (92.7 % selectivity in terms of Relectron ) and a 20.6 µmol g-1 h-1 evolution rate. Subsequent spectroscopic and microscopic studies supported by theoretical analysis revealed operando-generated Cu2+ , with the assistance of existing Cu+ , functioning as an anchor for the generated *CO and thereby facilitating C-C coupling. This study demonstrates strain-induced in situ surface reconstruction leading to heterojunction formation, which finetunes the oxidation state of Cu and modulates the CO2 reduction reaction pathway to selective formation of ethylene.

In Situ Mechanistic Insights for the Oxygen Reduction Reaction in Chemically Modulated Ordered Intermetallic Catalyst Promoting Complete Electron Transfer.

The well-known limitation of alkaline fuel cells is the slack kinetics of the cathodic half-cell reaction, the oxygen reduction reaction (ORR). Platinum, being the most active ORR catalyst, is still facing challenges due to its corrosive nature and sluggish kinetics. Many novel approaches for substituting Pt have been reported, which suffer from stability issues even after mighty modifications. Designing an extremely stable, but unexplored ordered intermetallic structure, Pd2Ge, and tuning the electronic environment of the active sites by site-selective Pt substitution to overcome the hurdle of alkaline ORR is the main motive of this paper. The substitution of platinum atoms at a specific Pd position leads to Pt0.2Pd1.8Ge demonstrating a half-wave potential (E1/2) of 0.95 V vs RHE, which outperforms the state-of-the-art catalyst 20% Pt/C. The mass activity (MA) of Pt0.2Pd1.8Ge is 320 mA/mgPt, which is almost 3.2 times better than that of Pt/C. E1/2 and MA remained unaltered even after 50,000 accelerated degradation test (ADT) cycles, which makes it a promising stable catalyst with its activity better than that of the state-of-the-art Pt/C. The undesired 2e- transfer ORR forming hydrogen peroxide (H2O2) is diminished in Pt0.2Pd1.8Ge as visible from the rotating ring-disk electrode (RRDE) experiment, spectroscopically visualized by in situ Fourier transform infrared (FTIR) spectroscopy and supported by computational studies. The effect of Pt substitution on Pd has been properly manifested by X-ray absorption spectroscopy (XAS) and X-ray photoelectron spectroscopy (XPS). The swinging of the oxidation state of atomic sites of Pt0.2Pd1.8Ge during the reaction is probed by in situ XAS, which efficiently enhances 4e- transfer, producing an extremely low percentage of H2O2.

Metagenomic views on taxonomic and functional profiles of the Himalayan Tsomgo cold lake and unveiling its deterzome potential.

Cold habitat is considered a potential source for detergent industry enzymes. This study aims at the metagenomic investigation of Tsomgo lake for taxonomic and functional annotation, unveiling the deterzome potential of the residing microbiota at this site. The present investigation revealed molecular profiling of microbial community structure and functional potential of the high-altitude Tsomgo lake samples of two different temperatures, harvested during March and August. Bacteria were found to be the most dominant phyla, with traces of genomic pieces of evidence belonging to archaea, viruses, and eukaryotes. Proteobacteria and Actinobacteria were noted to be the most abundant bacterial phyla in the cold lake. In-depth metagenomic investigation of the cold aquatic habitat revealed novel genes encoding detergent enzymes, amylase, protease, and lipase. Further, metagenome-assembled genomes (MAGs) belonging to the psychrophilic bacterium, Arthrobacter alpinus, were constructed from the metagenomic data. The annotation depicted the presence of detergent enzymes and genes for low-temperature adaptation in Arthrobacter alpinus. Psychrophilic microbial isolates were screened for lipase, protease, and amylase activities to further strengthen the metagenomic findings. A novel strain of Acinetobacter sp. was identified with the dual enzymatic activity of protease and amylase. The bacterial isolates exhibited hydrolyzing activity at low temperatures. This metagenomic study divulged novel genomic resources for detergent industry enzymes, and the bacterial isolates secreting cold-active amylase, lipase, and protease enzymes. The findings manifest that Tsomgo lake is a potential bioresource of cold-active enzymes, vital for various industrial applications.

Do the Benefits of Systemic Corticosteroids Outweigh Adverse Effects During Maxillofacial Trauma Surgery? A Systematic Review and Meta-Analysis.

PURPOSE: Perioperative systemic corticosteroids are widely used in maxillofacial trauma surgery to prevent postoperative complications, but potentially perceived benefits are speculative rather than evidence-based. The purpose of our systematic review and meta-analysis was to assess the effects of perioperative systemic corticosteroids on clinically significant outcomes in patients undergoing maxillofacial trauma surgery. METHODS: We searched Medline, Embase, CENTRAL, Clinical trial registry, and grey literature as well as references of included trials. Our primary outcomes were facial edema and pain after the surgery. Our secondary outcomes were postoperative nausea and vomiting, neurosensory disturbance, functional recovery, wound infections, and other adverse events. RESULTS: Of the 94 trials retrieved, 13 were included (n = 652). Perioperative steroid use was associated with reduced pain and facial edema. We observed a decrease in postoperative nausea and vomiting with the use of systemic corticosteroids (n = 184, OR = 0.53, [0.28, 1.02], I2 = 0%). Four trials reported infections and impaired wound healing associated with steroids (n = 160. OR = 3.37, [1.43. 7.94], I2 = 2%). The 13 trials had an unclear risk of bias. CONCLUSIONS: Systemic corticosteroids reduced facial edema and postoperative pain, but impaired wound healing was also reported. The use of systemic steroids in maxillofacial trauma surgery is thus supported only by weak evidence and further research is advocated.

Jungle rubber facilitates the restoration of degraded soil of an existing rubber plantation.

Conversion of forest to rubber plantation is one of the most common land-use change in the humid tropical region. It is one of the fastest expanding farms that lead to various socioenvironmental issues. We investigated the effect of this land-use change on soil physico-chemical properties by surveying different succession stage rubber plantations, including monoculture and a mixture derived by mixing jungle rubber and a reference tropical rainforest. We also assessed the impact on stoichiometric ratios and allocation relationships of soil carbon (C), nitrogen (N), and phosphorus (P). Our results demonstrated that conversion of tropical rainforest to rubber monoculture resulted in serious soil degradation, with a lower level of water content, water holding capacities, total porosity, pH, and soil nutrients, and a higher level of soil bulk density. However, after transforming a rubber monoculture into a jungle rubber, the concentrations of soil total C, N, P, Ca, and Mg significantly increased, by 28%, 24%, 23%, 17%, and 39%, respectively. Meanwhile, soil salinity declined by 15%. Jungle rubber also exerted some desirable effects on soil physical properties, such as decreased soil bulk density, increased field capacity and non-porosity by 6%, 2%, and 33%, respectively. Like other tropical regions, soils in the present study areas are mainly under P limitation, but jungle rubber increased soil P turnover and thereby increases P availability. In conclusion, jungle rubber correcting the soil degradation resulted from rubber plantation on tropical forest soil. Given the improvements in soil quality, constructing multiple-strata and multi-species rubber agroforestry (e.g., jungle rubber) can be a promising approach to facilitate the restoration of the existing monoculture rubber plantations.

Effects of hillslope position on soil water infiltration and preferential flow in tropical forest in southwest China.

The hillslope is an essential natural spatial gradient that influences hydrological processes by affecting water distribution, surface flow, soil erosion, and groundwater recharge. To date, few studies have addressed only the hydrological processes of tropical forest hillslopes. To reveal the effect of hillslope on soil hydrological functioning-including water distribution and exchange, infiltration capacity, and flow behaviour-we conducted 36 field infiltration and nine dye-tracer investigations of different hillslope locations in the natural rainforest of Xishuangbanna, southwest China. The soil physical properties-including soil noncapillary and total porosity, saturated water capacity, and field water capacity-decreased with decreasing elevation from hilltop to middle slope and the valley bottom. The water infiltration capacity-including the initial infiltration rate, saturated soil hydraulic conductivity, and average infiltration rate-decreased from the hilltop to the valley bottom. Preferential flow dominated soil water movement more in the upper locations than in the valley bottom. The infiltration capacity parameters and preferential flow were significantly correlated with soil water content, noncapillary and total porosity, root biomass, and termite holes. These results indicated that along with the soil physical properties, root systems, animal activity, cracks, and stones affected the soil infiltration capacity and preferential flow. Differences in the hydraulic processes of each hillslope position contributed to the redistribution, transportation, and storage of surface and belowground water, resulting in differing availabilities of soil water resources and utilisation by plants. The findings of this study can help understand eco-hydrological processes in the context of water resources management in tropical mountain ecosystems.

Soil quality assessment of different Hevea brasiliensis plantations in tropical China.

Land degradation is a global problem caused by improper agricultural practices. In tropical China, the rubber (Hevea brasiliensis) plantations are predominantly practiced on forest-cleared lands, considering their sustainable land management potential compared to annual cropping. However, all rubber plantations may not have similar land management capacity. Soil quality index (SQI) can reveal the overall soil status with a single score, which is an efficient tool to evaluate the soil quality of each category of rubber plantations. We investigated 23 soil physical and chemical parameters of three categories of rubber plantations and a primary rainforest, and derived SQI based on these parameters. Soil samples were collected from a rubber monoculture (RM), a rubber-Camellia sinensis agroforestry (RT), a rubber-Dracaena cochinchinensis agroforestry (RD), and a primary rainforest (RF). The results showed that the SQI value of the RM decreased by 15.50% compared to the RF, with a significant degree of soil nutrient loss (18.90%). This indicates that monocultural rubber cultivation is causing land degradation to some extent. However, the SQI was significantly enhanced by rubber-based agroforestry practices (25.30% by RT and 33.10% by RD) compared to the RM, suggesting that polyculture practices are suitable to recover the soil quality in degraded agricultural lands. Moreover, the chemical parameters contributed more to the SQI than did the physical parameters, indicating that nutrient management is important in soil quality recovery. Overall, our results suggest that agroforestry should be preferred over monoculture in the rubber plantations for sustainable land management in tropical China.

Toxicity Evaluation of Six Textile Dyes on Growth, Metabolism and Elemental Composition (C, H, N, S) of Microalgae Spirulina platensis: The Environmental Consequences.

A concentration-dependent decrease in growth rate and pigment concentration of the blue-green alga Spirulina platensis was recorded after the exposure to graded (5-40 ppm) concentration of six textile dyes. The profile of vital elements (C, H, N, S) also showed a significant variation due to dye toxicity. The algal population showed up to 50% decrease in protein content after exposure to the dyes. Among the pigments, the dye exposure resulted in > 90% decreases in phycocyanin however, total chlorophyll and carotenoids exhibited up to a 50% decrease compared to control. The findings indicate that the unregulated discharge of textile dyes will directly impact the photoautotrophic organisms leading to ecological imbalance in aquatic ecosystems. Overall observations of the report provide baseline information about the toxicity of textile dyes and giving a better insight into the little-understood mechanisms of dye toxicity.

Decay and erosion-related transport of sulfur compounds in soils of rubber based agroforestry.

Elemental sulfur is intensively used to control weeds and rubber leaf diseases. However, the mechanisms contributing to elemental sulfur dissipation and decay (hereafter decay) in rubber agroforestry remains unclear. This study relates hydrological processes such as runoff and soil loss to the changes in soil total sulfur (Stot) and sulfate (S-SO4) in typical hillslope rubber agroforestry intercropped with cocoa in Xishuangbanna. The elemental sulfur decay kinetics were studied at two slopes (top and bottom) and three agrosystems (weed, no-weed and mixed). The results show that soil moisture and hydraulic conductivity was uniformly distributed in the experimental rubber agroforestry settings. Higher soil loss and runoff occurred in the bottom slope than the top slope, and in no-weed agrosystem than the herbaceous agrosystems (weed and mixed). The soil loss was mainly driven by runoff. Moreover, Stot and S-SO4 in runoff water were higher in weed agrosystem than no-weed agrosystems. Soil Stot best fit a two-compartments kinetics model, with lower kinetic rates in elemental sulfur applied treatments than in the no-added elemental sulfur treatments, particularly for the weed agrosystem. The soil Stot dissipation time 50% (DT50) was 10-14 times higher in top slope than bottom slope; but 4 and 20 times higher in mixed and no-weed agrosystems, respectively, compared to the weed agrosystem. The soil Stot and S-SO4 contents negatively correlated with soil microbial respiration (CO2 efflux), indicating an adverse influence of elemental sulfur on soil microbial activity. In short, elemental sulfur decay and its S-SO4 transformation depended on soil moisture, runoff, soil erosion and soil CO2, which are in turn affected by slope and agrosystem. This study not only clarifies the mechanisms of elemental sulfur dissipation and decay for its use as an environmental friendly agrochemical; but it also provides information to understand the contribution of runoff and soil loss on these mechanisms in rubber agroforestry.

Tree growth rate regulate the influence of elevated CO2 on soil biochemical responses under tropical condition.

Tree growth rate can complicate our understandings of plant belowground responses to elevated CO2 (eCO2) in tropical ecosystems. We studied the effects of eCO2 on plant growth parameters, and rhizospheric soil properties including soil organic carbon (SOC), glomalin related soil protein (GRSP), microbial biomass C (Cmic), CO2 efflux (Cefflux), and microbial extracellular enzyme activities under two tropical tree saplings of fast-growing Tectona grandis (Teak) and slow-growing Butea monosperma (Butea). We exposed these saplings to eCO2 (∼550 ppm) and ambient CO2 (aCO2; ∼395 ppm) in the Indo-Gangetic plain region, and further (after 10 and 46 months) measured the changes in their rhizospheric soil properties. With respect to aCO2 treatment, eCO2 significantly increased plant height, stem and shoot weight, and total plant biomass of Teak. However, these plant traits did not considerably differed between eCO2 and aCO2 treatments of Butea. The eCO2 induced greater extent of increase in rhizospheric soil properties including SOC fractions (particulate OC, non-particulate OC and total OC), GRSP fractions (easily extractable- GRSP, difficulty extractable- GRSP and total- GRSP), Cmic, Cefflux and extracellular enzyme activities (phosphatase, dehydrogenase, ß-glucosidase and fluorescein diacetate) were observed under Teak compared with Butea. Compared with aCO2 treatment, eCO2 slightly reduced soil available N and P under the Teak, but no changes were apparent between eCO2 and aCO2 treatments of the Butea. The greater extent of responses from soil variables observed after longer period (46 months) of CO2 exposure. The multivariate analysis confirmed that eCO2 treatment with Teak is more responsive compared with other treatments of Teak and Butea. This contrasting rhizospheric soil feedback to eCO2 between two tropical trees, suggesting fast-growing species will be more responsive to future climate. Such species will have a competitive advantage over coexisting less responsive species (e.g. Butea) under future eCO2 climate.

Contribution of glomalin to dissolve organic carbon under different land uses and seasonality in dry tropics.

Glomalin related soil protein (GRSP) is a hydrophobic glycoprotein that is significant for soil organic carbon (SOC) persistence and sequestration, owing to its large contribution to SOC pool and long turnover time. However, the contribution of GRSP to dissolve OC (DOC) leach from soil is not yet comprehensively explored, though it could have implication in understanding SOC dynamics. We, therefore, aim to measure the contribution of GRSP to DOC, in a range of land uses and climatic seasons in the dry tropical ecosystem. Our results demonstrated that a significant proportion of GRSP (water soluble GRSP; WS-GRSP) leached with DOC (7.9-21.9 mg kg-1), which accounts for 0.2-0.23% of soils total GRSP (T-GRSP). Forest exhibited significantly higher WS-GRSP and DOC leaching than fallow and agriculture. WS-GRSP and DOC accumulations were higher in the dry season (summer and winter) than in rainy. The extent of seasonal variations was higher in forest than in other two land uses, indicating the role of vegetation and biological activity in soil dissolve organic matter (DOM) dynamics. The regression analysis among WS-GRSP, T-GRSP, DOC and SOC prove that the accumulations and leaching of GRSP and other soil OM (SOM) depend on similar factors. The ratio of WS-GRSP-C to DOC was higher in agriculture soil than in forest and fallow, likely a consequence of altered soil chemistry, and organic matter quantity and quality due to soil management practices. Multivariate analysis reflects a strong linkage among GRSP and SOC storage and leaching, soil nutrients (nitrogen and phosphorus) and other important soil properties (pH and bulk density), suggesting that improving GRSP and other SOM status is an urgent need for the both SOC sequestration and soil health in dry tropical agro-ecosystems.

Long-term follow up of single-stage anterior cruciate ligament reconstruction and high tibial osteotomy and its relation with posterior tibial slope.

BACKGROUND: Open-wedge high tibial osteotomy is considered to be an effective treatment for medial compartmental osteoarthritis. It is generally admitted that tibial slope increases after open-wedge high tibial osteotomy and decreases after closing-wedge high tibial osteotomy. Young patients with anterior cruciate ligament (ACL) deficiency along with medial compartment osteoarthritis need a combined procedure of ACL reconstruction along with high tibial osteotomy to regain physiological knee kinematics and to avoid chondral damage. MATERIALS AND METHODS: We retrospectively analysed data from 30 patients who underwent arthroscopic ACL reconstruction along with medial opening-wedge osteotomy from Jan 2004 to June 2012 with a minimum follow up of 2 years. The pre-operative and post-operative posterior tibial slopes were measured. Functional outcome was analysed using clinico-radiological criteria, IKDC scoring and Lysholm score. RESULTS: Post-operative patients improved both clinically and functionally. The patients who had posterior tibial slope >5° decrease, compared to patients who had less <5° decrease, had better functional scores (IKDC and Lysholm score), which was statistically significant (p < 0.05). CONCLUSION: Our study has shown that decreasing the tibial slope >5° compared to pre-operative value has functionally favourable effect on the reconstructed ACL graft and outcome. It is known that increasing slope causes an anterior shift in tibial resting position that is accentuated under axial loads. This suggests that decreasing tibial slope may be protective in an ACL deficient knee. Hence by placing the tricortical graft posterior to midline in the opening wedge reduces the posterior tibial slope and thereby reduces the stress on the graft leading to better functional outcome.

Outcomes and complications of fractures of distal radius (AO type B and C): volar plating versus nonoperative treatment.

OBJECTIVES: Management of AO type B and C fractures of the distal radius is controversial. This study compares outcomes and complications of AO type B and C fractures of the distal radius treated with volar locked plating and nonoperative methods. MATERIALS AND METHODS: Sixty-four patients with fractures of the distal radius (AO type B and C) were included in this study, according to inclusion criteria, and were allocated to the volar plating group or nonoperative group by alternate randomization: 32 patients with odd numbers went into the nonoperative group and the other 32 with even numbers went into the volar plating group. Patients in the nonoperative group were managed with closed reduction of the fracture and plaster cast application under an image intensifier. Those in the volar plating group were managed by open reduction and fixation with a volar locked plate. Preoperative and postoperative serial clinico-radiological follow-up was done. The range of movement, grip strength, functional outcome scores and radiological parameters were compared. Student's t-test was used for statistical analysis with significance at p < 0.05. RESULTS: Range of movement and functional scores were significantly (p < 0.001) better in the volar plating group, but the difference in ulnar variance and radial and ulnar deviation was insignificant as compared to the nonoperative group. At 24 months follow-up, the nonoperative group had significantly more cases with malunion, articular incongruity and osteoarthritis. CONCLUSION: In cases of AO type B or C fractures of the distal radius, volar locked plating provides anatomical stable fixation and early mobilization with better clinico-radiological outcome as compared to conservative treatment.

Treatment of non-union of humerus diaphyseal fractures: a prospective study comparing interlocking nail and locking compression plate.

BACKGROUND: The aim of this prospective comparative study was to compare outcomes and complications of humeral diaphyseal fracture non-unions managed with humerus interlocking nail (HIL) and locking compression plate (LCP). MATERIALS AND METHODS: 40 patients with non-union of humeral diaphyseal fractures were included in this study and were randomly allocated in two groups; group A had 20 cases treated with HIL and group B had 20 cases treated with LCP. Clinico-radiological assessments were done for each case up to 2-year follow-up period. Primary outcome measures (time to fracture union, union rate) and secondary outcome measures (functional outcome and complication such as infection, malunion, delayed union, implant failure, joint stiffness and iatrogenic radial nerve palsy) were compared between both the groups. Disabilities of the arm, shoulder and hand (DASH) scoring and Steward and Hundley's scoring system were used to assess functional outcome of the fracture fixation. RESULTS: There was no significant difference (p = 0.12) in terms of mean fracture union time between group A (15.8 ± 4.2 weeks) and group B (17.2 ± 3.8 weeks). Group A had 95 % union rate and group B had 100 % union rate (p = 0.14). At the 2-year follow-up visit, there was no significant difference found between both the groups regarding range of motion of shoulder and elbow joint. There was no significant difference found in final functional outcomes between both the groups on comparing DASH score (p = 0.14) and Steward and Hundley's score (p = 0.08). In terms of complications, there was insignificant difference found between both the groups. CONCLUSIONS: This study concludes that both the implants can be used in non-union of humeral shaft fractures with good functional outcomes and acceptable rate of complications.

Plate osteosynthesis of fractures of the shaft of the humerus: comparison of limited contact dynamic compression plates and locking compression plates.

BACKGROUND: The aim of this retrospective study was to compare outcomes and complications of displaced fractures of the shaft of the humerus treated with limited-contact dynamic compression plates (LCDCPs) and locking compression plates (LCPs). MATERIALS AND METHODS: Two hundred and twelve patients with displaced fractures of the shaft of the humerus, treated with plate osteosynthesis from January 2005 to December 2009 were reviewed. One hundred and two patients (group A) were treated with LCDCP osteosynthesis and 110 patients (group B) were treated with LCP osteosynthesis. Clinical and radiological assessments were made at monthly intervals for the first 6 months and then at 2-month intervals for the next 6 months. Primary outcome measures like operative time, duration of hospital stay, time to fracture union, union rate and secondary outcome measures (functional outcome and complications such as infection, malunion, delayed union, nonunion, implant failure and iatrogenic radial nerve palsy) were compared between both groups. The ULCA scoring system and Mayo elbow performance index (MEPI) were used to assess shoulder and elbow functions, respectively. Rodriguez-Merchan criteria were used to assess the functional outcomes of the fracture fixation. RESULTS: There was no significant difference found between the two groups in terms of primary outcome measures. According to Rodriguez-Merchan criteria, comparison of functional outcomes of both groups showed insignificant difference (p = 0.48). There was no significant difference found between the two groups regarding mean ULCA score (p = 0.34) and mean MEPI sore (p = 0.54). In terms of complications, no significant difference was found between the two groups. CONCLUSION: This study concludes that the principle of fracture fixation was more important than plate selection in fractures of the shaft of the humerus. LEVEL OF EVIDENCE: Level 3.

A Multiple Controlled Toffoli Driven Adaptive Quantum Neural Network Model for Dynamic Workload Prediction in Cloud Environments.

The key challenges in cloud computing encompass dynamic resource scaling, load balancing, and power consumption. Accurate workload prediction is identified as a crucial strategy to address these challenges. Despite numerous methods proposed to tackle this issue, existing approaches fall short of capturing the high-variance nature of volatile and dynamic cloud workloads. Consequently, this paper introduces a novel model aimed at addressing this limitation. This paper presents a novel Multiple Controlled Toffoli-driven Adaptive Quantum Neural Network (MCT-AQNN) model to establish an empirical solution to complex, elastic as well as challenging workload prediction problems by optimizing the exploration, adaption, and exploitation proficiencies through quantum learning. The computational adaptability of quantum computing is ingrained with machine learning algorithms to derive more precise correlations from dynamic and complex workloads. The furnished input data point and hatched neural weights are refitted in the form of qubits while the controlling effects of Multiple Controlled Toffoli (MCT) gates are operated at the hidden and output layers of Quantum Neural Network (QNN) for enhancing learning capabilities. Complimentarily, a Uniformly Adaptive Quantum Machine Learning (UAQL) algorithm has evolved to functionally and effectually train the QNN. The extensive experiments are conducted and the comparisons are performed with state-of-the-art methods using four real-world benchmark datasets. Experimental results evince that MCT-AQNN has up to 32%-96% higher accuracy than the existing approaches.

A sustainable and secure load management model for green cloud data centres.

The massive upsurge in cloud resource demand and inefficient load management stave off the sustainability of Cloud Data Centres (CDCs) resulting in high energy consumption, resource contention, excessive carbon emission, and security threats. In this context, a novel Sustainable and Secure Load Management (SaS-LM) Model is proposed to enhance the security for users with sustainability for CDCs. The model estimates and reserves the required resources viz., compute, network, and storage and dynamically adjust the load subject to maximum security and sustainability. An evolutionary optimization algorithm named Dual-Phase Black Hole Optimization (DPBHO) is proposed for optimizing a multi-layered feed-forward neural network and allowing the model to estimate resource usage and detect probable congestion. Further, DPBHO is extended to a Multi-objective DPBHO algorithm for a secure and sustainable VM allocation and management to minimize the number of active server machines, carbon emission, and resource wastage for greener CDCs. SaS-LM is implemented and evaluated using benchmark real-world Google Cluster VM traces. The proposed model is compared with state-of-the-arts which reveals its efficacy in terms of reduced carbon emission and energy consumption up to 46.9% and 43.9%, respectively with improved resource utilization up to 16.5%.