Detalhe da pesquisa
1.
Fluoromethylcyclopropylamine derivatives as potential in vivo toxicophores - A cautionary disclosure.
Bioorg Med Chem Lett
; 29(4): 560-562, 2019 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30616904
2.
Development of 5-hydroxypyrazole derivatives as reversible inhibitors of lysine specific demethylase 1.
Bioorg Med Chem Lett
; 27(14): 3190-3195, 2017 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28545974
3.
Anilinoquinazoline inhibitors of the RET kinase domain-Elaboration of the 7-position.
Bioorg Med Chem Lett
; 26(11): 2724-9, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27086121
4.
Measurement of binding of basic drugs to acidic phospholipids using surface plasmon resonance and incorporation of the data into mechanistic tissue composition equations to predict steady-state volume of distribution.
Drug Metab Dispos
; 39(10): 1789-93, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21764943
5.
Elevated plasma 2-hydroxyglutarate in acute myeloid leukaemia: association with the IDH1 SNP rs11554137 and severe renal impairment.
Br J Haematol
; 166(1): 145-8, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24606602
6.
Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.
J Med Chem
; 61(23): 10767-10792, 2018 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30403352
7.
Elevated Hypothalamic Glucocorticoid Levels Are Associated With Obesity and Hyperphagia in Male Mice.
Endocrinology
; 157(11): 4257-4265, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-27649090
8.
Identification of selective inhibitors of RET and comparison with current clinical candidates through development and validation of a robust screening cascade.
F1000Res
; 5: 1005, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27429741
9.
First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib.
ACS Chem Biol
; 11(11): 3179-3190, 2016 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27689388
10.
Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells.
J Med Chem
; 59(24): 11120-11137, 2016 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28002956
11.
The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity.
Eur J Med Chem
; 112: 20-32, 2016 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26874741
12.
Toxoflavins and deazaflavins as the first reported selective small molecule inhibitors of tyrosyl-DNA phosphodiesterase II.
J Med Chem
; 56(16): 6352-70, 2013 Aug 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-23859074
13.
Novel steroid inhibitors of glucose 6-phosphate dehydrogenase.
J Med Chem
; 55(9): 4431-45, 2012 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-22506561