Detalhe da pesquisa
1.
EFHD1 promotes osteosarcoma proliferation and drug resistance by inhibiting the opening of the mitochondrial membrane permeability transition pore (mPTP) by binding to ANT3.
Cell Mol Life Sci
; 81(1): 236, 2024 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38795203
2.
Recent advances of LSD1/KDM1A inhibitors for disease therapy.
Bioorg Chem
; 134: 106443, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36857932
3.
Crystallographic landscape of SHP2 provides molecular insights for SHP2 targeted drug discovery.
Med Res Rev
; 42(5): 1781-1821, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35575058
4.
Discovery and pharmacodynamic evaluation of the novel butene lactone derivative M355 against influenza A virus in vitro and in vivo.
J Med Virol
; 94(9): 4393-4405, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35560068
5.
Emerging therapeutic approaches of SHP2-targeted modulators.
Future Med Chem
; 16(4): 291-294, 2024 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38275153
6.
Low expression of ZFP36L1 in osteosarcoma promotes lung metastasis by inhibiting the SDC4-TGF-ß signaling feedback loop.
Oncogene
; 43(1): 47-60, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37935976
7.
Predictive Value of Lysophosphatidylcholine for Determining the Disease Severity and Prognosis of Elderly Patients with Community-Acquired Pneumonia.
Clin Interv Aging
; 19: 517-527, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38528884
8.
Structural and Functional Landscape of FAD-Dependent Histone Lysine Demethylases for New Drug Discovery.
J Med Chem
; 66(1): 71-94, 2023 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36537915
9.
The influence of organic components in sludge on selective non-catalytic reduction denitrification.
Environ Sci Pollut Res Int
; 30(51): 111221-111230, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37807028
10.
Development of a robust HTRF assay with USP7 full length protein expressed in E. coli prokaryotic system for the identification of USP7 inhibitors.
J Pharm Biomed Anal
; 227: 115305, 2023 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36812797
11.
Inhibition of Heat Shock-Induced H3K9ac Reduction Sensitizes Cancer Cells to Hyperthermia.
Int J Biol Sci
; 19(15): 4849-4864, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37781518
12.
SIRPA enhances osteosarcoma metastasis by stabilizing SP1 and promoting SLC7A3-mediated arginine uptake.
Cancer Lett
; 576: 216412, 2023 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37769797
13.
Double-edged roles of protein tyrosine phosphatase SHP2 in cancer and its inhibitors in clinical trials.
Pharmacol Ther
; 230: 107966, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34403682
14.
Repurposing antidepressants for anticancer drug discovery.
Drug Discov Today
; 27(7): 1924-1935, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34728374
15.
Strategies Targeting Protein Tyrosine Phosphatase SHP2 for Cancer Therapy.
J Med Chem
; 65(4): 3066-3079, 2022 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35157464
16.
Annual review of lysine-specific demethylase 1 (LSD1/KDM1A) inhibitors in 2021.
Eur J Med Chem
; 228: 114042, 2022 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34915312
17.
Harnessing the cyclization strategy for new drug discovery.
Acta Pharm Sin B
; 12(12): 4309-4326, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36562004
18.
Structure-based design, synthesis and biological evaluation of aminopyrazines as highly potent, selective, and cellularly active allosteric SHP2 inhibitors.
Eur J Med Chem
; 230: 114106, 2022 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35063735
19.
A multifunctional cross-validation high-throughput screening protocol enabling the discovery of new SHP2 inhibitors.
Acta Pharm Sin B
; 11(3): 750-762, 2021 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-33777680
20.
Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors in clinical trials for cancer immunotherapy.
J Hematol Oncol
; 14(1): 68, 2021 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33883013