RESUMO
Necrotizing fasciitis (NF) is a severe infection involving the superficial fascia, subcutaneous tissue, and, occasionally, deeper tissue layers. Usual treatment is with surgical debridement in combination with antibiotics. In review of the literature there is one neonatal report of NF associated with necrotizing enterocolitis. We present a case report of a 25 week gestation infant with necrotizing fasciitis and the complexity of wound and pain management presented for the nursing staff in the neonatal intensive care unit.
Assuntos
Enterocolite Necrosante/complicações , Enterocolite Necrosante/enfermagem , Fasciite Necrosante/complicações , Fasciite Necrosante/enfermagem , Doenças do Prematuro/enfermagem , Comorbidade , Desbridamento , Enterocolite Necrosante/cirurgia , Fasciite Necrosante/cirurgia , Evolução Fatal , Humanos , Recém-Nascido , Doenças do Prematuro/cirurgia , Masculino , Tratamento de Ferimentos com Pressão Negativa , Equipe de Assistência ao Paciente , Perda Insensível de ÁguaRESUMO
A series of pyrimidine based inhibitors of PDE7 are discussed. The synthesis, structure-activity relationships (SAR) and selectivity against several other PDE family members as well as activity in T cells are presented. These compounds were found to have effects on T cell proliferation, however it is not clear whether the mechanism is related to PDE7 inhibition.
Assuntos
Nucleotídeo Cíclico Fosfodiesterase do Tipo 7/antagonistas & inibidores , Inibidores de Fosfodiesterase/química , Pirimidinas/química , Linfócitos T/efeitos dos fármacos , Animais , Proliferação de Células/efeitos dos fármacos , Nucleotídeo Cíclico Fosfodiesterase do Tipo 7/genética , Nucleotídeo Cíclico Fosfodiesterase do Tipo 7/metabolismo , Técnicas de Inativação de Genes , Camundongos , Inibidores de Fosfodiesterase/síntese química , Inibidores de Fosfodiesterase/farmacologia , Pirimidinas/síntese química , Pirimidinas/farmacologia , Relação Estrutura-Atividade , Linfócitos T/imunologiaRESUMO
A series of fused pyrimidine based inhibitors of PDE7 have been derived from an earlier screening lead 1. The synthesis, structure-activity relationships (SAR) and selectivity against several other PDE family members are described.