Motor, cognitive and mobility deficits in 1000 geriatric patients: protocol of a quantitative observational study before and after routine clinical geriatric treatment - the ComOn-study.

BACKGROUND: Motor and cognitive deficits and consequently mobility problems are common in geriatric patients. The currently available methods for diagnosis and for the evaluation of treatment in this vulnerable cohort are limited. The aims of the ComOn (COgnitive and Motor interactions in the Older populatioN) study are (i) to define quantitative markers with clinical relevance for motor and cognitive deficits, (ii) to investigate the interaction between both motor and cognitive deficits and (iii) to assess health status as well as treatment outcome of 1000 geriatric inpatients in hospitals of Kiel (Germany), Brescia (Italy), Porto (Portugal), Curitiba (Brazil) and Bochum (Germany). METHODS: This is a prospective, explorative observational multi-center study. In addition to the comprehensive geriatric assessment, quantitative measures of reduced mobility and motor and cognitive deficits are performed before and after a two week's inpatient stay. Components of the assessment are mobile technology-based assessments of gait, balance and transfer performance, neuropsychological tests, frailty, sarcopenia, autonomic dysfunction and sensation, and questionnaires to assess behavioral deficits, activities of daily living, quality of life, fear of falling and dysphagia. Structural MRI and an unsupervised 24/7 home assessment of mobility are performed in a subgroup of participants. The study will also investigate the minimal clinically relevant change of the investigated parameters. DISCUSSION: This study will help form a better understanding of symptoms and their complex interactions and treatment effects in a large geriatric cohort.

Reliability of the N2-component in a modified 3-stimulus concealed information test: On the importance of excellent measurement accuracy.

Research on deception focused on the investigation of event-related potentials (ERP) to facilitate our knowledge on cognitive-motivational processes underlying deception. We investigated the reliability of the frontal N2 amplitude in a modified Concealed Information Test (CIT) (N = 64 participants). Variations of Cronbach's Alpha coefficients were examined for number of epochs per stimulus type, task modality and types of ERP quantification. Cronbach's Alpha coefficients of the N2 increased with the number of epochs across task modality, stimulus types and electrode positions. In a pictorial CIT, the frontal N2 indicated excellent Cronbach's Alpha coefficients (≥ 0.90) across electrode positions and quantification methods for 25 epochs per stimulus type. At least 15 epochs were necessary to achieve excellent Cronbach's Alpha coefficients (≥ 0.90) of the peak-to-peak N2 in a modified CIT across electrode positions and stimulus types. We provide best-practice advises for the necessity to assess N2 in a modified CIT with excellent reliability.