Detalhe da pesquisa
1.
Preclinical PK/PD modeling and human efficacious dose projection for a glucokinase activator in the treatment of diabetes.
J Pharmacokinet Pharmacodyn
; 41(2): 127-39, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24578187
2.
Structure-based design, SAR analysis and antitumor activity of PI3K/mTOR dual inhibitors from 4-methylpyridopyrimidinone series.
Bioorg Med Chem Lett
; 23(9): 2787-92, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23506825
3.
Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of PI3Kα and mTOR.
Bioorg Med Chem Lett
; 22(15): 5098-103, 2012 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22749419
4.
Liverome: a curated database of liver cancer-related gene signatures with self-contained context information.
BMC Genomics
; 12 Suppl 3: S3, 2011 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-22369201
5.
Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors.
Bioorg Med Chem Lett
; 21(4): 1270-4, 2011 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21269826
6.
Steady-state kinetic and inhibition studies of the mammalian target of rapamycin (mTOR) kinase domain and mTOR complexes.
Biochemistry
; 49(39): 8488-98, 2010 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-20804212
7.
4-methylpteridinones as orally active and selective PI3K/mTOR dual inhibitors.
Bioorg Med Chem Lett
; 20(20): 6096-9, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20817449
8.
Biochemical characterization of MODY2 glucokinase variants V62M and G72R reveals reduced enzymatic activities relative to wild type.
Biochemistry
; 48(11): 2514-21, 2009 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-19187021
9.
Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers.
PLoS One
; 13(6): e0198374, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29879184
10.
Ligand and coactivator recruitment preferences of peroxisome proliferator activated receptor alpha.
J Steroid Biochem Mol Biol
; 81(3): 217-25, 2002 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12163133
11.
Effective targeting of Hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective Smoothened antagonist that penetrates the blood-brain barrier.
Mol Cancer Ther
; 11(1): 57-65, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22084163
12.
PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity.
Mol Cancer Ther
; 10(11): 2189-99, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21750219
13.
Ligand-induced coactivator recruitment to peroxisome proliferator-activated receptor alpha characterized by fluorescence resonance energy transfer.
Methods Enzymol
; 357: 180-8, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-12424909
14.
Glucose modulation of glucokinase activation by small molecules.
Biochemistry
; 47(17): 5028-36, 2008 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-18370405
15.
Biochemical basis of glucokinase activation and the regulation by glucokinase regulatory protein in naturally occurring mutations.
J Biol Chem
; 281(52): 40201-7, 2006 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-17082186
16.
Glucose-induced conformational changes in glucokinase mediate allosteric regulation: transient kinetic analysis.
Biochemistry
; 45(24): 7553-62, 2006 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-16768451
17.
Pyridine-2-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents.
Bioorg Med Chem Lett
; 16(23): 6116-9, 2006 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16979341
18.
Pyridine-3-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents.
Bioorg Med Chem Lett
; 16(23): 6120-3, 2006 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16973358
19.
Assay development and data analysis of receptor-ligand binding based on scintillation proximity assay.
Metab Eng
; 7(1): 38-44, 2005 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-15721809
20.
Quantitative analysis of c-myc-tagged protein in crude cell extracts using fluorescence polarization.
Anal Biochem
; 307(2): 287-96, 2002 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12202246