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1.
Opt Express ; 32(10): 17738-17762, 2024 May 06.
Artigo em Inglês | MEDLINE | ID: mdl-38858948

RESUMO

Multi-directional polarized optical sensors are increasingly vital in passive remote sensing, deepening our understanding of global cloud properties. Nevertheless, uncertainty lingers on how these observations can contribute to our knowledge of cloud diversity. The variability in cloud PSD (Particle Size Distribution) significantly influences a wide array of cloud characteristics, while unidentified factors in RT (Radiative Transfer) may introduce errors into the cloud PSD retrieval algorithm. Therefore, establishing unified evaluation criteria for both optical device configuration and inversion methods is crucial. Our study, based on Bayesian theory and RT, assesses the information content of both cloud effective radius and effective variance retrieval, along with the key factors affecting their retrieval in multi-directional polarized observations, using the calculation of DFS (Degree of Freedom for Signals).We consider the process of solar incidence, cloud scattering, and sensor reception, and discuss the impact of various sensor configurations, cloud characteristics, and other components on the retrieval of cloud PSD. Correspondingly, we observed a 48% improvement in the information content of cloud PSD with the incorporation of multi-directional polarized measurements in the rainbow region. Cloud droplet concentration significantly influences inversion, but its PSD does not cause monotonic linear interference on information content. The blending of particle mixtures with different PSD has a significant negative impact on DFS. In cases where the AOD (Aerosol Optical Depth) is less than 0.5 and the COT (Cloud Optical Thickness) exceeds 5, the influence of aerosol and surface contributions on inversion can be neglected. Our findings would serve as a foundation for future instrument design improvements and enhancements to retrieval algorithms.

2.
Artigo em Inglês | MEDLINE | ID: mdl-38536473

RESUMO

Several studies have reported that baseline symptom severity in patients with schizophrenia (SCZ) is associated with the efficacy of antipsychotic medication. Overweight/obesity is common in SCZ and has also been reported to be correlated with therapeutic response to antipsychotics. This study aimed to evaluate whether baseline body mass index (BMI) and disease severity were associated with improvements in negative symptoms in patients with first-episode and medication-naïve (FEMN) SCZ. A total of 241 FEMN patients were recruited in this study and treated with oral risperidone over 3 months. Clinical symptoms were measured by the Positive and Negative Syndrome Scale (PANSS) and BMI was assessed at baseline and 3-month follow-up. We found that baseline BMI was correlated with the baseline severity of symptoms. Baseline BMI or baseline disease severity was associated with improvement in negative symptoms after 3 months of treatment. Linear regression analysis indicated that the interaction of BMI and disease severity at baseline was associated with improvement in negative symptoms in the early stage of SCZ after controlling for sex, age, and dose of risperidone. Our study suggests that the interaction of baseline BMI and disease severity may play a role in predicting negative symptom improvement after 3 months of risperidone treatment.

3.
Sensors (Basel) ; 24(12)2024 Jun 10.
Artigo em Inglês | MEDLINE | ID: mdl-38931553

RESUMO

The division of focal plane (DoFP) polarization detector has great potential for the development of aerospace polarimeters, but the existing commercial DoFP polarization detector cannot satisfy all the missions due to the diversity of satellite payloads. Here, we propose a method of directly writing a micro-polarizer array (MPA) on the detector surface based on focused ion beams (FIB) and fabricating a push-broom scanning DoFP polarization detector. The feasibility and low crosstalk of the solution were proved through testing, and the reasons for the low extinction ratio caused by oxidation were explained through characterization and numerical calculations. This scheme is not only applicable to DoFP polarization detectors but also provides ideas for the integration of other metasurface structures and detectors.

4.
J Minim Access Surg ; 2024 Jan 09.
Artigo em Inglês | MEDLINE | ID: mdl-38289023

RESUMO

INTRODUCTION: This study aimed to investigate the feasibility of applying laparoscopic transection and partial resection of hernia sac in the treatment of indirect inguinal hernia in children. PATIENTS AND METHODS: From December 2017 to November 2018, we recruited 20 children, who were aged 1-6 years old, with indirect inguinal hernia. At the time of admission, the participants had already developed an indirect inguinal hernia for 6 months to 1 year. A simple transection and partial resection of hernia sac was performed at the internal ring on each of the recruited children. The procedure was conducted under laparoscopy. Two 5-mm trocars were placed on either side of the umbilicus, one for the camera and the other for a surgical instrument. Another trocar was placed on the right abdomen. Laparoscopic camera curved forceps, and scissors were placed. Along the unclosed internal ring, the peritoneum was cut in a circular fashion to transect the hernia sac and dissociate it from the distal end. About 1-2 cm of the hernia sac was resected. RESULTS: The operation was successfully completed in all 20 cases, who did not experience any complications, such as the absence of spermatic cord, vas deferens injury, scrotal swelling and incision infection. The children were discharged 1 day after the operation. In the post-operative follow-up for the first 3-4 years, recurrence and testicular atrophy did not occur in the study participants. CONCLUSION: The short-term results obtained from this study showed that the application of laparoscopic transection and partial resection of hernia sac in the treatment of indirect inguinal hernia is feasible. Long-term results and further observation are needed for validation.

5.
Appl Opt ; 61(33): 9795-9800, 2022 Nov 20.
Artigo em Inglês | MEDLINE | ID: mdl-36606808

RESUMO

In this paper, a complete investigation and simulation of the extinction ratio (ER) in a setup with a micro-polarizer array (MPA) is performed. A metal grid substrate structure, which can effectively reduce optical crosstalk and improve the ER, is proposed. The numerical calculation results show that the ER of our proposed structure is more than 10-fold higher than that of the traditional structure. Moreover, the effect of its structural parameters to the ER has been researched, and the results showed that when the substrate is thicker, the incident angle of light is less than 15°, the metal width is larger than 900 nm, and a complete grating with more than 20 periods on a single pixel can obtain a high ER.

6.
Biomed Microdevices ; 23(2): 29, 2021 05 11.
Artigo em Inglês | MEDLINE | ID: mdl-33974162

RESUMO

Sensitive and rapid tests of Escherichia coli drug sensitivity is very important for health of human and animals. An E. coli immunosensor was built based on electrochemical detection and immune detection technologies, through pretreating screen-printed electrodes, and analyzing the optimal reaction concentration of antigen antibody binding with the AC impedance method. Based on the detection system combining the immunosensor and electrochemical workstation, tests were carried out to measure the accuracy of E. coli concentration and drug sensitivity, and error of the detection system was calibrated in accordance with data from the electrochemical workstation. E. coli O157:H7 can be detected in the range of 103 cfu/ml ~ 1012 cfu/ml, and the detection error controlled within 5%. Results from the electrochemical workstation and those from the detection device were consistent, and both demonstrated a greater inhibitory effect of antibiotics on E. coli than on Bacillus subtilis. The electrochemical detection system is highly efficient and accurate, and could be widely applied to E. coli drug sensitivity tests in clinical medicine.


Assuntos
Técnicas Biossensoriais , Escherichia coli O157 , Preparações Farmacêuticas , Animais , Eletrodos , Humanos , Imunoensaio
7.
Appl Opt ; 59(1): 151-155, 2020 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-32225281

RESUMO

Polarimetric imaging detection is a relatively new and largely undeveloped field. Although convolutional neural networks (CNNs) have achieved great success in two-dimensional (2D) normal intensity images in the field of target detection, traditional CNN methods have not been widely applied to optical polarimetric images, and they cannot take full advantage of the connection between different polarimetric images. To solve this problem, three-dimensional (3D) convolutions are adopted to consider the relationship between S0, S1, and S2 images as a third dimension. Based on the 3D convolutions, a CNN with 3D and 2D convolutional layers is introduced to further improve the success rate of target detection with limited polarimetric images. The evaluations in different natural backgrounds reveal that the proposed method achieves higher detection accuracy than that of two traditional methods for comparison.

8.
Gastroenterology ; 155(6): 1908-1922.e5, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-30217742

RESUMO

BACKGROUND & AIMS: Hirschsprung disease, or congenital aganglionosis, is believed to be oligogenic-that is, caused by multiple genetic factors. We performed whole-genome sequence analyses of patients with Hirschsprung disease to identify genetic factors that contribute to disease development and analyzed the functional effects of these variants. METHODS: We performed whole-genome sequence analyses of 443 patients with short-segment disease, recruited from hospitals in China and Vietnam, and 493 ethnically matched individuals without Hirschsprung disease (controls). We performed genome-wide association analyses and gene-based rare-variant burden tests to identify rare and common disease-associated variants and study their interactions. We obtained induced pluripotent stem cell (iPSC) lines from 4 patients with Hirschsprung disease and 2 control individuals, and we used these to generate enteric neural crest cells for transcriptomic analyses. We assessed the neuronal lineage differentiation capability of iPSC-derived enteric neural crest cells using an in vitro differentiation assay. RESULTS: We identified 4 susceptibility loci, including 1 in the phospholipase D1 gene (PLD1) (P = 7.4 × 10-7). The patients had a significant excess of rare protein-altering variants in genes previously associated with Hirschsprung disease and in the ß-secretase 2 gene (BACE2) (P = 2.9 × 10-6). The epistatic effects of common and rare variants across these loci provided a sensitized background that increased risk for the disease. In studies of the iPSCs, we observed common and distinct pathways associated with variants in RET that affect risk. In functional assays, we found variants in BACE2 to protect enteric neurons from apoptosis. We propose that alterations in BACE1 signaling via amyloid ß precursor protein and BACE2 contribute to pathogenesis of Hirschsprung disease. CONCLUSIONS: In whole-genome sequence analyses of patients with Hirschsprung disease, we identified rare and common variants associated with disease risk. Using iPSC cells, we discovered some functional effects of these variants.


Assuntos
Sistema Nervoso Entérico/crescimento & desenvolvimento , Doença de Hirschsprung/genética , Secretases da Proteína Precursora do Amiloide/metabolismo , Ácido Aspártico Endopeptidases/metabolismo , Estudos de Casos e Controles , Diferenciação Celular , China , Predisposição Genética para Doença , Variação Genética , Humanos , Células-Tronco Pluripotentes Induzidas , Crista Neural/fisiologia , Fosfolipase D/metabolismo , Proteínas Proto-Oncogênicas c-ret/metabolismo , Transdução de Sinais/genética , Vietnã , Sequenciamento Completo do Genoma
9.
Guang Pu Xue Yu Guang Pu Fen Xi ; 36(5): 1434-9, 2016 May.
Artigo em Zh | MEDLINE | ID: mdl-30001022

RESUMO

As a novel remote sensing technique, polarimetric detecting technology is a useful supplement to traditional hyperspectral remote sensing technology, which provides more information for remote sensing. By taking advantage of the polarization characteristics of the surface reflecting light of soil with different moisture, the polarization spectral method is applied to measure soil moisture. The spectropolarimeter was used to measure the polarized reflectance spectrum of different soil moisture. The correlation between soil moisture and polarization spectrum was analyzed. The polarization characteristics of soil surface reflecting light in different viewing angles were surveyed by experiments. The experimental results show that: in the higher soil moisture conditions, the polarization spectrum and soil moisture have a certain connection, especially in the 500~700 nm band and soil moisture is directly proportional to the degree of polarization; but in low soil moisture conditions, the correlation of polarization spectrum and soil moisture is not obvious; in addition, the polarization spectrum are influenced by viewing angles, for example, when the incident angle of source light is fixed at 50°, while the viewing angle of instrument is between 20° and 60°, the degree of polarization increases with the viewing angle. When the viewing angle becomes wider,, the degree of polarization changed more significantly with the soil moisture.

10.
Hum Mol Genet ; 22(3): 621-31, 2013 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-23108157

RESUMO

Anorectal malformations (ARMs, congenital obstruction of the anal opening) are among the most common birth defects requiring surgical treatment (2-5/10 000 live-births) and carry significant chronic morbidity. ARMs present either as isolated or as part of the phenotypic spectrum of some chromosomal abnormalities or monogenic syndromes. The etiology is unknown. To assess the genetic contribution to ARMs, we investigated single-nucleotide polymorphisms and copy number variations (CNVs) at genome-wide scale. A total of 363 Han Chinese sporadic ARM patients and 4006 Han Chinese controls were included. Overall, we detected a 1.3-fold significant excess of rare CNVs in patients. Stratification of patients by presence/absence of other congenital anomalies showed that while syndromic ARM patients carried significantly longer rare duplications than controls (P = 0.049), non-syndromic patients were enriched with both rare deletions and duplications when compared with controls (P = 0.00031). Twelve chromosomal aberrations and 114 rare CNVs were observed in patients but not in 868 controls nor 11 943 healthy individuals from the Database of Genomic Variants. Importantly, these aberrations were observed in isolated ARM patients. Gene-based analysis revealed 79 genes interfered by CNVs in patients only. In particular, we identified a de novo DKK4 duplication. DKK4 is a member of the WNT signaling pathway which is involved in the development of the anorectal region. In mice, Wnt disruption results in ARMs. Our data suggest a role for rare CNVs not only in syndromic but also in isolated ARM patients and provide a list of plausible candidate genes for the disorder.


Assuntos
Anus Imperfurado/genética , Anus Imperfurado/fisiopatologia , Variações do Número de Cópias de DNA , Duplicação Gênica , Peptídeos e Proteínas de Sinalização Intercelular/genética , Animais , Malformações Anorretais , Povo Asiático , Aberrações Cromossômicas , Feminino , Dosagem de Genes , Regulação da Expressão Gênica , Estudo de Associação Genômica Ampla , Humanos , Peptídeos e Proteínas de Sinalização Intercelular/metabolismo , Masculino , Camundongos , Camundongos Endogâmicos ICR , Fenótipo , Polimorfismo de Nucleotídeo Único , Estudos Prospectivos , Via de Sinalização Wnt
11.
Pancreatology ; 15(3): 286-94, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25804129

RESUMO

BACKGROUND AND AIM: Questions remain unclear about the association of smoking status and the development of acute pancreatitis (AP). We performed a meta-analysis of observational studies explore this association. METHODS: A computerized literature search was performed in MEDLINE and EMBASE through November 30, 2014. We also searched the reference lists of pertinent articles. We used a random-effects model to calculate the summary relative risks (SRRs) and their corresponding 95% confidence intervals (CIs). RESULTS: A total of 3690 incident cases of AP included 12 observational studies (6 case-control and 6 prospective cohort/nested case-control studies) were identified. Compared with never smokers, the summary RR estimates were 1.54 (95% CI, 1.31-1.80) for ever smokers, 1.71 (95% CI, 1.37-2.14) for current smokers, and 1.21 (95% CI, 1.02-1.43) for former smokers. Smoking is found to be a potential risk factor for alcohol use, idiopathic factors and drugs related AP, but not for gallstone related AP, in the ever and current smokers. A dose-response effect of tobacco use on the risk was ascertained: current smokers had a 40% (95% CI, 30%-51%) increased risk of AP for every additional 10 cigarettes per day. CONCLUSION: The present analysis suggests that smokers have an elevated risk of AP development. Further studies, however, are warranted before definitive conclusions can be drawn.


Assuntos
Pancreatite/etiologia , Fumar/efeitos adversos , Doença Aguda , Humanos , Modelos Estatísticos , Estudos Observacionais como Assunto , Fatores de Risco
12.
Artigo em Inglês | MEDLINE | ID: mdl-38625777

RESUMO

A series of discrete time-variant matrix inequalities is generally regarded as one of the challenging problems in science and engineering fields. As a discrete time-variant problem, the existing solving schemes generally need the theoretical support under the continuous-time framework, and there is no independent solving scheme under the discrete-time framework. The theoretical deficiency of solving scheme greatly limits the theoretical research and practical application of discrete time-variant matrix inequalities. In this article, new discrete-time recurrent neural network (RNN) algorithms are proposed, analyzed, and investigated for solving different time-variant matrix inequalities under the discrete-time framework, including discrete time-variant matrix vector inequality (discrete time-variant MVI), discrete time-variant generalized matrix inequality (discrete time-variant GMI), discrete time-variant generalized-Sylvester matrix inequality (discrete time-variant GSMI), and discrete time-variant complicated-Sylvester matrix inequality (discrete time-variant CSMI), and all solving processes are based on the direct discretization thought. Specifically, first of all, four discrete time-variant matrix inequalities are presented as the target problems of these researches. Second, for solving such problems, we propose corresponding discrete-time recurrent neural network (RNN) (DT-RNN) algorithms (termed DT-RNN-MVI algorithm, DT-RNN-GMI algorithm, DT-RNN-GSMI algorithm, and DT-RNN-CSMI algorithm), which are different from the traditional DT-RNN design thought because second-order Taylor expansion is applied to derive the DT-RNN algorithms. This creative process avoids the intervention of continuous-time framework. Then, theoretical analyses are presented, which show the convergence and precision of the DT-RNN algorithms. Abundant numerical experiments are further carried out, which further confirm the excellent properties of the DT-RNN algorithms.

13.
Curr Med Imaging ; 2023 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-36924091

RESUMO

OBJECTIVE: This study aims to discuss the treatment of congenital recto-vestibular fistula and recto-perineal fistula, and the effect of the megarectum on defecation. BACKGROUND: Congenital recto-vestibular fistula or recto-perineal fistula is the most common type of anorectal malformation, and surgical methods include posterior sagittal anorectoplasty, anterior sagittal anorectoplasty, and mid-sagittal anorectoplasty, which can be performed at stage one or stage two after the ostomy. In the later stages of a recto-vestibular fistula, constipation is a common complication. Rectal dilatation is frequently associated with constipation, and the effect of rectal dilatation on defecation should be discussed for patients with congenital recto-vestibular or recto-perineal fistula who had rectal dilatation prior to surgery. Rectal dilatation may be one of the causes of constipation for congenital recto-vestibular fistula and recto-perineal fistula. METHODS: The patients in this study were 67 children with congenital recto-vestibular fistula or recto-perineal fistula treated in our hospital from March 2013 to February 2017. All patients underwent an MRI of the spine and a barium enema. Six patients with myelodysplasia and sacral agenesis were excluded from this study. There were 18 patients with rectal dilatation (ages: 4-month-old to 1 year old, male: 3, female: 15). Seven of them had anterior sagittal anorectoplasty (group A), and 11 had anorectoplasty with dilated rectum resection (group B). Forty-three patients (ages: 3- to 10 months old, male: 6; female: 37) without a dilated rectum underwent anterior sagittal anorectoplasty (group C). RESULTS: All patients were followed up for 1 year to 5 years. Among the 50 patients who had undergone an anoplasty, 5 out of 7 patients with rectal dilatation developed post-operative constipation, and 3 of them had normal defecation after the second resection of the dilated rectum. Only two out of 43 patients without rectal dilatation developed post-operative constipation. One out of 11 patients with rectal dilatation who underwent anoplasty and resection of the dilated rectum developed post-operative constipation. CONCLUSION: Patients with congenital recto-vestibular fistula or recto-perineal fistula complicated by rectal dilatation are more susceptible to post-operative constipation. Resection of the dilated rectum at the same time can reduce the incidence rate of constipation. A barium enema should be performed pre-operatively for patients with congenital recto-vestibular fistula or recto-perineal fistula. If the dilated rectum is found, it can be resected at the same time.

14.
IEEE Trans Neural Netw Learn Syst ; 34(6): 2781-2790, 2023 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-34524961

RESUMO

Controlling and processing of time-variant problem is universal in the fields of engineering and science, and the discrete-time recurrent neural network (RNN) model has been proven as an effective method for handling a variety of discrete time-variant problems. However, such model usually originates from the discretization research of continuous time-variant problem, and there is little research on the direct discretization method. To address the aforementioned problem, this article introduces a novel discrete-time RNN model for solving the discrete time-variant problem in a pioneering manner. Specifically, a discrete time-variant nonlinear system, which originates from the mathematical modeling of serial robot manipulator, is presented as a target problem. For solving the problem, first, the technique of second-order Taylor expansion is used to deal with the discrete time-variant nonlinear system, and the novel discrete-time RNN model is proposed subsequently. Second, the theoretical analyses are investigated and developed, which shows the convergence and precision of the proposed discrete-time RNN model. Furthermore, three distinct numerical experiments verify the excellent performance of the proposed discrete-time RNN model. In addition, a robot manipulator example further verifies the effectiveness and practicability of the proposed novel discrete-time RNN model.

15.
Neural Netw ; 164: 428-438, 2023 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-37182345

RESUMO

Discrete time-variant nonlinear optimization (DTVNO) problems are commonly encountered in various scientific researches and engineering application fields. Nowadays, many discrete-time recurrent neurodynamics (DTRN) methods have been proposed for solving the DTVNO problems. However, these traditional DTRN methods currently employ an indirect technical route in which the discrete-time derivation process requires to interconvert with continuous-time derivation process. In order to break through this traditional research method, we develop a novel DTRN method based on the inspiring direct discrete technique for solving the DTVNO problem more concisely and efficiently. To be specific, firstly, considering that the DTVNO problem emerging in the discrete-time tracing control of robot manipulator, we further abstract and summarize the mathematical definition of DTVNO problem, and then we define the corresponding error function. Secondly, based on the second-order Taylor expansion, we can directly obtain the DTRN method for solving the DTVNO problem, which no longer requires the derivation process in the continuous-time environment. Whereafter, such a DTRN method is theoretically analyzed and its convergence is demonstrated. Furthermore, numerical experiments confirm the effectiveness and superiority of the DTRN method. In addition, the application experiments of the robot manipulators are presented to further demonstrate the superior performance of the DTRN method.


Assuntos
Robótica , Robótica/métodos , Engenharia
16.
Front Pediatr ; 11: 1095054, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37051433

RESUMO

Background: To assess the effect of megarectum on postoperative defecation of female patients with congenital rectovestibular fistula or rectoperineal fistula. Methods: From March 2013 to February 2021, 74 female patients with congenital rectovestibular fistula or rectoperineal fistula were treated. The age of patients ranged from 3 months to 1 year. Barium enema and spinal cord MRI were performed in all children. 4 patients were removed from the study because of spinal cord and sacral agenesis. Finally, 70 patients underwent one-stage anterior sagittal anorectoplasty (ASARP). Anal endoscopy and anorectal pressure measurement were performed 1 year after surgery. All patients were divided into two groups depending on the presence of megarectum (+) and (-) and observed for constipation and anal sphincter function. Results: 16 patients (4 months to 1 year) were complicated with megarectum, and 5 patients (3 months to 9 months) were without megarectum. The incision infection was seen in 3 patients. All patients were followed up for 1 year to 5 years. Fecal soiling was seen in 2 patients and constipation in 14 patients. Among 16 patients with megarectum, soiling was seen in 1 patient and the constipation in 12 patients. Among 54 patients without megarectum, soiling was seen in 1 patient and constipation in 2 patients. There was a significant difference in the incidence of postoperative constipation between the two groups (megarectum (+) 75% vs. megarectum (-) 3.7% (P < 0.05)). However, there was no significant difference in the score of anal sphincters between the two groups (P < 0.05). And there was no significant difference in anal resting pressure (P = 0.49) and length of anal high pressure area (P = 0.76). 7 patients with constipation and megarectum acquired normal anal function after the dilated rectum was resected. Conclusion: Megarectum increases the possibility of difficult postoperative defecation in the patients with congenital rectovestibular fistula or rectoperineal fistula. However, constipation was not associated with ASARP postoperative effects on sphincter function. Resection of megarectum is helpful to the improvement of constipation.

17.
Proc Natl Acad Sci U S A ; 106(8): 2694-9, 2009 Feb 24.
Artigo em Inglês | MEDLINE | ID: mdl-19196962

RESUMO

Hirschsprung's disease (HSCR), or aganglionic megacolon, is a congenital disorder characterized by the absence of enteric ganglia in variable portions of the distal intestine. RET is a well-established susceptibility locus, although existing evidence strongly suggests additional loci contributing to sporadic HSCR. To identify these additional genetic loci, we carried out a genome-wide association study using the Affymetrix 500K marker set. We successfully genotyped 293,836 SNPs in 181 Chinese subjects with sporadic HSCR and 346 ethnically matched control subjects. The SNPs most associated with HSCR were genotyped in an independent set of 190 HSCR and 510 control subjects. Aside from SNPs in RET, the strongest overall associations in plausible candidate genes were found for 2 SNPs located in intron 1 of the neuregulin1 gene (NRG1) on 8p12, with rs16879552 and rs7835688 yielding odds ratios of 1.68 [CI(95%):(1.40, 2.00), P = 1.80 x 10(-8)] and 1.98 [CI(95%):(1.59, 2.47), P = 1.12 x 10(-9)], respectively, for the heterozygous risk genotypes under an additive model. There was also a significant interaction between RET and NRG1 (P = 0.0095), increasing the odds ratio 2.3-fold to 19.53 for the RET rs2435357 risk genotype (TT) in the presence of the NRG1 rs7835688 heterozygote, indicating that NRG1 is a modifier of HSRC penetrance. Our highly significant association findings are backed-up by the important role of NRG1 as regulator of the development of the enteric ganglia precursors. The identification of NRG1 as an additional HSCR susceptibility locus not only opens unique fields of investigation into the mechanisms underlying the HSCR pathology, but also the mechanisms by which a discrete number of loci interact with each other to cause disease.


Assuntos
Predisposição Genética para Doença , Genoma Humano , Doença de Hirschsprung/genética , Proteínas do Tecido Nervoso/genética , Feminino , Marcadores Genéticos , Estudo de Associação Genômica Ampla , Humanos , Masculino , Neuregulina-1 , Polimorfismo de Nucleotídeo Único , Proteínas Proto-Oncogênicas c-ret/genética
18.
Front Genet ; 13: 891265, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35719384

RESUMO

The last decades have witnessed a vast amount of interest and research in feature representation learning from multiple disciplines, such as biology and bioinformatics. Among all the real-world application scenarios, feature extraction from knowledge graph (KG) for personalized recommendation has achieved substantial performance for addressing the problem of information overload. However, the rating matrix of recommendations is usually sparse, which may result in significant performance degradation. The crucial problem is how to extract and extend features from additional side information. To address these issues, we propose a novel feature representation learning method for the recommendation in this paper that extends item features with knowledge graph via triple-autoencoder. More specifically, the comment information between users and items is first encoded as sentiment classification. These features are then applied as the input to the autoencoder for generating the auxiliary information of items. Second, the item-based rating, the side information, and the generated comment representations are incorporated into the semi-autoencoder for reconstructed output. The low-dimensional representations of this extended information are learned with the semi-autoencoder. Finally, the reconstructed output generated by the semi-autoencoder is input into a third autoencoder. A serial connection between the semi-autoencoder and the autoencoder is designed here to learn more abstract and higher-level feature representations for personalized recommendation. Extensive experiments conducted on several real-world datasets validate the effectiveness of the proposed method compared to several state-of-the-art models.

20.
Guang Pu Xue Yu Guang Pu Fen Xi ; 30(11): 3086-92, 2010 Nov.
Artigo em Zh | MEDLINE | ID: mdl-21284189

RESUMO

Compared with the spectral detection method, polarization detection could obtain more information of the target. For example, the polarization detection could be applied to interpret the refractive index and the surface roughness of the object, or retrieve the soil moisture, etc. Polarization detection provides a new approach to quantitative retrieval of soil moisture, and this is very important in agriculture, hydrology, meteorology and ecology. The polarization characteristics of soil surface with low vegetation cover,which is a example of mixed pixel in remote sensing, were researched with experiments, and the relationship between the polarization characteristics and soil moisture was also explored. The results showed that the polarization characteristics of soil surface with low vegetation cover are mainly determined by the area of bare soil, and are strongly relevant with the soil moisture. For the results of experiments in this paper, the IDOLP of soil surface with low vegetation cover increased with increasing soil moisture when the viewing angle of instrument was between 20 degree and 60 degree, while the incident angle of light source was fixed at 40 degree. This paper offered a new method to retrieve moisture content of soil with low vegetation cover.

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