Detalhe da pesquisa
1.
A method for estimating the glomerular filtration rate in conscious monkeys.
J Appl Toxicol
; 36(2): 266-70, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25994107
2.
Bayesian approach enabled objective comparison of multiple human iPSC-derived Cardiomyocytes' Proarrhythmia sensitivities.
J Pharmacol Toxicol Methods
; : 107531, 2024 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38852688
3.
Lead optimization of 5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxyhexanamides to reduce a cardiac safety issue: discovery of DS-8108b, an orally active renin inhibitor.
Bioorg Med Chem
; 21(11): 3175-96, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23598247
4.
N-Aryl Indoles as a Novel Class of Potent NaV1.7 Inhibitors.
ACS Med Chem Lett
; 14(6): 788-793, 2023 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37312847
5.
Reliable identification of cardiac conduction abnormalities in drug discovery using automated patch clamp II: Best practices for Nav1.5 peak current in a high throughput screening environment.
J Pharmacol Toxicol Methods
; 112: 107125, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34500078
6.
Comprehensive Cardiac Safety Assessment using hiPS-cardiomyocytes (Consortium for Safety Assessment using Human iPS Cells: CSAHi).
Curr Pharm Biotechnol
; 21(9): 829-841, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-31749424
7.
Reliable identification of cardiac liability in drug discovery using automated patch clamp: Benchmarking best practices and calibration standards for improved proarrhythmic assessment.
J Pharmacol Toxicol Methods
; 105: 106884, 2020 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-32565325
8.
Discovery of DS-1971a, a Potent, Selective NaV1.7 Inhibitor.
J Med Chem
; 63(18): 10204-10220, 2020 09 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32392056
9.
Muscle relaxant and neurotoxic activities of intrathecal baclofen in rats.
Pharmacol Res
; 60(5): 392-6, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19577646
10.
Electrophysiological evaluation of pentamidine and 17-AAG in human stem cell-derived cardiomyocytes for safety assessment.
Eur J Pharmacol
; 842: 221-230, 2019 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30391349
11.
Gene expression profiles in the articular cartilage of juvenile rats receiving the quinolone antibacterial agent ofloxacin.
Toxicology
; 249(2-3): 204-13, 2008 Jul 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-18572299
12.
On-chip spatiotemporal electrophysiological analysis of human stem cell derived cardiomyocytes enables quantitative assessment of proarrhythmia in drug development.
Sci Rep
; 8(1): 14536, 2018 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30266924
13.
Comprehensive in vitro cardiac safety assessment using human stem cell technology: Overview of CSAHi HEART initiative.
J Pharmacol Toxicol Methods
; 83: 42-54, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-27646297
14.
Anticonvulsant and neuroprotective effects of the novel nootropic agent nefiracetam on kainic acid-induced seizures in rats.
Brain Res
; 1057(1-2): 168-76, 2005 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-16122714
15.
Estimation of glomerular filtration rate in dogs by a single-blood sample method involving iodixanol.
Am J Vet Res
; 76(9): 828-35, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26309112
16.
Comparison of sensitivity of surrogate markers of drug-induced torsades de pointes in canine hearts.
Eur J Pharmacol
; 502(1-2): 117-22, 2004 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-15464097
17.
In vivo experimental approach for the risk assessment of fluoroquinolone antibacterial agents-induced long QT syndrome.
Eur J Pharmacol
; 486(2): 189-200, 2004 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-14975708
18.
Tocolytic effects of formoterol are associated with local change in the progesterone/estradiol ratio.
Eur J Obstet Gynecol Reprod Biol
; 107(2): 163-7, 2003 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-12648862
19.
Estimation of glomerular filtration rate in cynomolgus monkeys (Macaca fascicularis).
J Vet Med Sci
; 76(10): 1423-6, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24998395
20.
On-chip in vitro cell-network pre-clinical cardiac toxicity using spatiotemporal human cardiomyocyte measurement on a chip.
Sci Rep
; 4: 4670, 2014 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-24751527