[Proposal of Information Management Method in Heat Generation of Magnetic Resonance Examination].

The safety management information related to heat generation in magnetic resonance imaging (MRI) examinations includes the specific absorption rate (SAR), the root mean square (RMS) of the MRI effective component of the B1 field (B1+rms), and imaging time, which must be set appropriately before an MRI examination. However, unlike image attributes and data, these three parameters do not require any image storage; therefore, information collection and confirmation post-inspection are difficult. Therefore, in this study, we used Digital Imaging and Communications in Medicine of SAR and imaging time using the overlay function of the picture archiving and communication systems (PACS) to confirm the specific absorption rate B1+rms and imaging time post-inspection. The medicine identification tag information was displayed on the PACS viewer. For some imaging times, the console display during scanning and the PACS viewer display did not match. However, the SAR console display during scanning and the PACS viewer display matched well, thereby rendering it easier to manage safety in MRI examinations.

[An Examination for Uterine Dynamic Study with Phase-sensitive Inversion-recovery].

The depth of myometrial invasion in patients with endometrial carcinoma is recognized as an important factor that closely correlates with prognosis. Preoperative assessment of myometrial invasion is essential for planning surgery. To enhance the contrast between myometrium and endometrium including myometrial invasion with endometrial carcinoma, we optimized the sequence parameter with phase-sensitive inversion-recovery (PSIR) in gadolinium dynamic study of uterine corpus. On a 1.5-T magnetic resonance imaging (MRI), images were acquired by three-dimensional (3D) T1 -turbo field echo (TFE) with PSIR sequence and gadolinium-diethylenetriamine pentaacetic acid( Gd-DTPA) diluted phantom (0-5 mmol/L) and myometrium model (manganese chloride tetrahydrate+agar). We calculated the null point and the contrast-to-noise ratio (CNR) at multiple TFE inversion delay times, 200 ms-maximum in each combination; flip angles (FAs), 5-35 degrees; TFE factor, 20-40; and shot interval (SI), 500-1000 ms. We assumed that dynamic scanning time was 30 seconds when the sensitivity encoding factor was 2, namely, in this study, the scanning time was 1 minute with no sensitivity encoding. In addition, we compared CNR between optimized PSIR sequence ande-Thrive. We recognized a successful CNR of the 3D PSIR parameter was TFE inversion delay times, 335 ms; FA, 25 degrees; TFE factor, 20; and SI, 500 ms. In each gadolinium-DTPA diluted phantom, the average CNR of the optimized PSIR sequence was approximately 1.7 times (maximum: 3 times) higher than e-Thrive. Optimizing sequence parameter of PSIR is applicable in gadolinium dynamic study of uterine corpus.

Magnetic resonance imaging relaxation times of female reproductive organs.

BACKGROUND: Relaxation time of female reproductive organs affects the tissue contrast of magnetic resonance image (MRI), and is used for quantitative analysis. PURPOSE: To evaluate the relaxation times of normal female reproductive organs in the luteal phase of the menstrual cycle. MATERIAL AND METHODS: On a 1.5-T MRI, relaxation times were measured in pelvic tissues (endometrium, junctional zone, myometrium, follicle, and stroma) of 32 female healthy volunteers (33.5 ± 6.8 years). The Look-Locker sequence was used to measure T1 relaxation times. Furthermore, a multiple spin-echo method with 32 different echo times was used to measure T2 relaxation times. The images were obtained in the luteal phase of each volunteer's menstrual cycle. RESULTS: The measured relaxation times (means ± standard deviations) were as follows: endometrium (T1, 1703 ± 147 ms; T2, 214 ± 35 ms), junctional zone (T1, 1168 ± 63 ms; T2, 72 ± 12 ms), myometrium (T1, 1314 ± 103 ms; T2, 138 ± 20 ms), follicle (T1, 2267 ± 49 ms; T2, 603 ± 68 ms), and stroma (T1, 1481 ± 129 ms; T2, 126 ± 29 ms). CONCLUSION: Reliable MRI measurements of T1 and T2 relaxation times of normal female reproductive organs in the luteal phase of the menstrual cycle are useful as references to recognize the normal value.

[Quantification and improvement of speech transmission performance using headphones in acoustic stimulated functional magnetic resonance imaging].

Functional magnetic resonance imaging (fMRI) has made a major contribution to the understanding of higher brain function, but fMRI with auditory stimulation, used in the planning of brain tumor surgery, is often inaccurate because there is a risk that the sounds used in the trial may not be correctly transmitted to the subjects due to acoustic noise. This prompted us to devise a method of digitizing sound transmission ability from the accuracy rate of 67 syllables, classified into three types. We evaluated this with and without acoustic noise during imaging. We also improved the structure of the headphones and compared their sound transmission ability with that of conventional headphones attached to an MRI device (a GE Signa HDxt 3.0 T). We calculated and compared the sound transmission ability of the conventional headphones with that of the improved model. The 95 percent upper confidence limit (UCL) was used as the threshold for accuracy rate of hearing for both headphone models. There was a statistically significant difference between the conventional model and the improved model during imaging (p < 0.01). The rate of accuracy of the improved model was 16 percent higher. 29 and 22 syllables were accurate at a 95% UCL in the improved model and the conventional model, respectively. This study revealed the evaluation system used in this study to be useful for correctly identifying syllables during fMRI.

Can Three-Dimensional T1-weighted MR Imaging Visualize the Vascular Lumen after Carotid Artery Stenting?

PURPOSE: We aimed to evaluate the quality of various 3D T1-weighted images (T1WIs) of the stent lumen using a carotid stent phantom and determine the suitable T1WI sequence for visualization of the stent lumen after carotid artery stenting. METHODS: The carotid stent phantom consisted of polypropylene tubes that mimicked common carotid arteries with and without stenting. On 1.5T and 3.0T MRI scanners, transverse T1WIs of the carotid stent phantom were obtained using 3D turbo spin-echo (TSE), 3D fast field-echo (3D-FFE), and 3D turbo field echo volumetric interpolated breath-hold examination (VIBE) under clinical conditions. The signal intensity ratio (SIR) was determined using the mean signal intensity of the stent lumen (SIstent) divided by the lumen without a stent in each T1WI. The SNR of the stent lumen (SNRstent) was calculated from SIstent divided by the standard deviation of the uniform region near the stent lumen. RESULTS: The 3D-FFE and VIBE had higher SNRstent than other T1WIs and clearly visualized the stent lumen. The 3D-TSE had the lowest SIR and SNRstent, preventing stent lumen visualization. CONCLUSION: T1WIs obtained using 3D-FFE and VIBE allows stent lumen visualization.

Usefulness of fat-containing agents: an initial study on estimating fat content for magnetic resonance imaging.

This initial study aimed at testing whether fat-containing agents can be used for the fat mass estimation methods using magnetic resonance imaging (MRI). As an example for clinical application, fat-containing agents (based on soybean oil, 10% and 20%), 100% soybean oil, and saline as reference substances were placed outside the proximal femurs obtained from 14 participants and analyzed by 0.3 T MRI. Fat content was the estimated fat fraction (FF) based on signal intensity (SIeFF, %). The SIeFF values of the femoral bone marrow, including the femoral head, neck, shaft, and trochanter area, were measured. MRI data were compared in terms of bone mineral content (BMC) and bone mineral density (BMD) by dual-energy X-ray absorptiometry (DXA) in the proximal femur. Twelve pig femurs were also used to confirm the correlation between FF by the DIXON method and SIeFF. According to Pearson's correlation coefficient, the SIeFF and total BMC and BMD data revealed strong and moderate negative correlations in the femoral head (r < - 0.74) and other sites (r = - 0.66 to - 0.45). FF and SIeFF showed a strong correlation (r = 0.96). This study was an initial investigation of a method for estimating fat mass with fat-containing agents and showed the potential for use in MRI. SIeFF and FF showed a strong correlation, and SIeFF and BMD and BMC showed correlation; however, further studies are needed to use SIeFF as a substitute for DXA.

Assessing the radiofrequency shielding effect of titanium mesh on diffusion-weighted imaging: a comparative study of the twice-refocused spin-echo and Stejskal-Tanner sequences.

This study compared twice-refocused spin-echo sequence (TRSE) and Stejskal-Tanner sequence (ST) to evaluate their respective effects on the image quality of magnetic resonance (MR) diffusion-weighted imaging in the presence of radiofrequency (RF) shielding effect of titanium mesh in cranioplasty. A 1.5-T MR scanner with a Head/Neck coil 20 channels and a phantom simulating the T2 and apparent diffusion coefficient (ADC) value of the human brain were used. Imaging was performed with and without titanium mesh placed on the phantom in TRSE and ST, and normalized absolute average deviation (NAAD), Dice similarity coefficient (DSC), and ADC values were calculated. The NAAD values were significantly lower for TRSE than for ST in the area below the titanium mesh, and the drop rates due to titanium mesh were 14.1% for TRSE and 9.8% for ST. The DSC values were significantly lower for TRSE than for ST. The ADC values were significantly higher for TRSE than for ST without titanium mesh. The ADC values showed no significant difference between TRSE and ST with titanium mesh. The ST had a lower RF shielding effect of titanium mesh than the TRSE.

Simulation of time-intensity curve based on k-space filling in breast dynamic contrast-enhanced three-dimensional magnetic resonance imaging.

This study elucidated the effects of a three-dimensional k-space trajectory incorporating the partial Fourier (PF) technique on a time-intensity curve (TIC) in a dynamic contrast-enhanced magnetic resonance imaging of a typical malignant breast tumor using a digital phantom. Images were obtained from the Cancer Imaging Archive Open Data for Breast Cancer, and 1-min scans with high temporal resolution were analyzed. The order of the k-space trajectory was set as Linear (sequential), Low-High (centric), PF (62.5%; Z-, Y-, and both directions), and Low-High Radial. k0 (center of the k-space) timing and TIC shape were affected by the chosen k-space trajectory and implementation of the PF technique. A small TIC gradient was obtained using a Low-High Radial order. If the k-space filling method (particularly the radial method) produces a gentle TIC gradient, misinterpretation could arise during the assessment of tumor malignancy status.

Carotid and aortic plaque imaging using 3D gradient-echo imaging and the three-point Dixon method with improved motion-sensitized driven-equilibrium (iMSDE).

BACKGROUND: We devised a method that combines the 3D-Dixon-gradientecho (GRE) method with an improved motion-sensitized driven-equilibrium (iMSDE) to suppress blood flow signals. PURPOSE: The purpose of this study was to evaluate the effectiveness of the new method we developed plaque imaging method (3D-Dixon-GRE with the iMSDE method). STUDY TYPE: Retrospective cohort. POPULATION: Thirty-nine patients who underwent cervical plaque imaging. FIELD STRENGTH/SEQUENCE: 3.0 T/3D-GRE. ASSESSMENT: Signal intensities of the common carotid artery, aorta, plaque, muscle, and subcutaneous fat were measured through the VISTA and the 3D-Dixon-GRE with iMSDE methods, and each contrast was calculated. STATISTICAL TEST: Used the Mann Whitney U test. P-values below 0.05 were considered statistically significant. RESULTS: Plaque and muscle contrast estimated through the VISTA method and 3D-Dixon-GRE with iMSDE method was 1.60 ± 0.96 and 2.04 ± 1.06, respectively, (P < 0.05). The contrast between the flow (common carotid artery and Aorta) and muscle according to the VISTA method and 3D-Dixon-GRE with iMSDE method was 0.24 ± 0.11 and 0.40 ± 0.12, respectively (P < 0.001). Finally, the mean contrast for subcutaneous fat and muscle at six locations was 3.05 ± 1.25 and 0.81 ± 0.23 for the VISTA method and 3D-Dixon-GRE with the iMSDE method, respectively (P < 0.001). DATA CONCLUSION: Compared to the conventional method (VISTA), the 3D-Dixon-GRE with iMSDE method is preferable in relation to the fat suppression effect, but it is disadvantageous regarding blood flow signal suppression. Therefore, the 3D-Dixon-GRE with the iMSDE method could be considered useful for plaque imaging.

[Study of image quality at various positions of reference scan].

In magnetic resonance imaging (MRI), we can use sensitivity encoding (SENSE) as a parallel imaging reconstruct from aliasing based on the sensitivity map of each coil element by reference scan. We researched SENSE reconstruction depending on the position of the reference scan. 1.5 T MRI (Achiva, Philips), 32-channel SENSE cardiac coil and rectangular solid phantom (nickel chloride) were used. Seven slices (A to G: from head to foot) were set at the phantom, slice thickness was 1 cm, and each slice interval was 5 cm. When T2 weighted axial images (TR: 3000 ms, TE: 120 ms) were taken, the center of the reference scan (C-Ref) was changed A to G, SENSE factor was changed 1 to 5, and number of signals averaged (NSA) was changed 1 to 3 with fold over suppression. Signal-to-noise ratio (SNR) and coefficient of variation (CV) from 9 regions of interest (ROI) of axial images were calculated. The SNR of slices A and G were lower than the other slices. %CV of slices F with C-Ref D was 69.4% lower than C-Ref A. %CV of slices D to F were higher than the other slices when C-Ref was A. %CV had no relation with SNR. Therefore, a 30 cm area around the center of reference can obtain best SENSE reconstruction.

[Study of skin markers for magnetic resonance imaging examinations].

In magnetic resonance imaging (MRI), skin markers are used as a landmark in order to make plans for examinations. However, there isn't a lot of research about the material and shape of skin markers. The skin marker's essential elements are safety, good cost performance, high signal intensity for T1 weighted image (T1WI) and T2 weighted image (T2WI), and durable. In order to get a high signal-to-noise ratio (SNR) of T1WI and T2WI, baby oil, salad oil and olive oil were chosen, because these materials were easy to obtain and safe for the skin. The SNR of baby oil was the best. Baby oil was injected into the infusion tube, and the tube was solvent welded and cut by a heat sealer. In order to make ring shaped skin markers, both ends of the tube were stuck with adhesive tape. Three different diameters of markers were made (3, 5, 10 cmψ). Ring shaped skin markers were put on to surround the examination area, therefore, the edge of the examination area could be seen at every cross section. Using baby oil in the ring shaped infusion tube is simple, easy, and a highly useful skin marker.

[Trial for power spectrum analysis in various injection timing for contrast medium].

Frequency analysis is a method of measuring the spatial frequency component in images. We attempted to analyze and assess frequency analyses of images of various contrast medium injection timings using a normalized integral power spectrum. In magnetic resonance imaging, the k-space order was linear and sequential. During the twenty-second scanning time, we injected contrast medium at 3 ml/s and varied the duration of the injection from zero to four seconds, four to eight seconds, eight to twelve seconds, twelve to sixteen seconds, and sixteen to twenty seconds. We then analyzed the images. The rates of change and area values were calculated, and a dendrogram of area value by cluster analysis was made. The element of high frequency area's power values rose when the contrast medium was in the high-frequency area, and the element of low frequency area's power values rose when the contrast medium was in the low-frequency area. These data lines crossed at 0.092-0.115 cycles/mm. Five time durations were identified: these were a function of rate of change and area value. Frequency analysis of injection timing for contrast medium using the normalized integral power spectrum can thus be applied; this method can thus be employed as a method of examining injection timing for contrast medium and choosing a k-space order of optimization.

Dependence of apparent diffusion coefficient on slice position in magnetic resonance diffusion imaging.

PURPOSE: The position dependence of the apparent diffusion coefficient (ADC) in magnetic resonance imaging (MRI) by echo-planar imaging (EPI)- and turbo spin echo (TSE)-diffusion-weighted imaging (DWI) was assessed using phantoms. METHODS: Six pure water-filled containers were placed parallel to the direction of the static magnetic field from the center of the magnetic field to the foot direction (five containers) and the head direction (one container). Six slice positions were set, and a cross-section image was scanned at the center of each container using a 1.5-T MRI scanner. Diffusion times for both EPI- and TSE-DWI were matched as much as possible. The slice thickness was adjusted to match the signal-to-noise ratio (SNR) at the center of the magnetic field for both sequences. A B1 map was analyzed. The ADC and SNR at each position of both sequences were tested using the Wilcoxon signed-rank test (P = 0.05) and compared using Friedman and Steel-Dwass multiple comparison tests (P = 0.05). Pearson correlation coefficients between ADC and SNR and between ADC and flip angle (FA) were calculated. RESULTS: ADC decreased significantly with distance from the center of the magnetic field for both EPI-DWI and TSE-DWI (P < 0.05). TSE-ADC was significantly higher than EPI-ADC for all combinations (P < 0.01). Based on the Friedman test, the SNR of EPI- and TSE-DWI was significantly different and depended on the slice position (P < 0.01). The Pearson correlation coefficient between ADC and SNR was 0.78 in EPI-DWI and 0.60 in TSE-DWI, whereas that between ADC and FA was 0.97 in EPI-DWI and 0.94 in TSE-DWI. The FA decreased by 0.048 and 0.047° per mm from the center of the magnetic field to head and foot directions, respectively. CONCLUSION: ADC depends on the slice position and decreases with an increase in distance from the magnetic field center. Caution should be taken when comparing and quantitatively evaluating the ADC at sites shifted in the long-axis direction.

Can magnetic resonance imaging after cranioplasty using titanium mesh detect brain tumors?

This study determined the dependence of the concentration and position of contrast-enhanced tumors on the radio frequency (RF)-shielding effect of titanium mesh using the contrast-to-noise ratio (CNR) in magnetic resonance imaging (MRI). A phantom was constructed by filling a plastic container with manganese chloride tetrahydrate and agar. Four cellophane cylindrical containers were arranged from the end of the plastic container, and the brain tumor model was filled with gadobutrol diluted with NaCl, with molarity values of 0.2-1.0 mmol/L. The titanium mesh board was set on the left side of the phantom. Images were acquired using a 1.5-T MRI as well as two-dimensional spin-echo (2D SE) and three-dimensional fast spoiled gradient echo (3D FSPGR) sequences. CNR was calculated using the signal intensity values of the tumor model, surrounding area of the brain model, and background noise. Furthermore, the fractional change in CNR was calculated using values of CNR with and without the mesh. Moreover, a profile of CNR was created. The fractional change in CNR decreased at the brain tumor positions present near the mesh and at a contrast medium concentration of approximately ≤ 0.5 mmol/L in 2D SE and ≤ 0.25 mmol/L in 3D FSPGR. According to the CNR profiles, directly under the mesh, almost all contrast concentrations in 2D SE was unrecognizable; however, at a concentration of ≥ 0.5 mmol/L in 3D FSPGR was recognizable.

Effect of acoustic noise reduction technology on image quality: a multivendor study.

The purpose of this study was to clarify the appropriate use of a combination of pulse sequences and acoustic noise reduction technology in general-purpose brain magnetic resonance imaging. Five pulse sequences commonly used in brain magnetic resonance imaging examinations-turbo spin-echo T2-weighted imaging, T1-weighted fluid-attenuated inversion recovery, T2-weighted fluid-attenuated inversion recovery, diffusion-weighted imaging, and magnetic resonance angiography-were performed on healthy participants at three vendors where acoustic noise reduction technology was available. The results showed that acoustic noise reduction technology reduced sound pressure levels and altered image quality in all pulse sequences across all vendors' magnetic resonance imaging scanners. Although T2-weighted imaging and T1-weighted fluid-attenuated inversion recovery resulted in little image quality degradation, T2-weighted fluid-attenuated inversion recovery, diffusion-weighted imaging, and magnetic resonance angiography had significant image degradation. Therefore, acoustic noise reduction technology should be used with caution.