Psychological risk and protective factors associated with depression among older adults in mainland China: A systematic review and meta-analysis.

BACKGROUND: Although geriatric depression is a public health concern in mainland China, findings about its psychological risk and protective factors have been inconsistent, and its prevention programmes have been deficient. To improve interventions for geriatric depression, we designed a study to systematically estimate the effect size of those factors. METHODS: To identify psychological risk and protective factors of geriatric depression, we conducted two independent literature searches in English- and Chinese-language databases, and we used a random effects model to analyse effect sizes. RESULTS: We identified 15 psychological risk and protective factors in 66 studies. The pooled effect sizes between the factors and geriatric depression ranged from 0.129 to 0.567. Self-esteem displayed a large effect size with depression (r = -0.567), whereas medium-to-large effect sizes emerged between geriatric depression and negative perceptions of age (r = 0.452), resilience (r = -0.426), rumination (r = 0.432), neuroticism (r = 0.381), extraversion (r = -0.363), self-efficacy (r = -0.357), sense of control (r = -0.343), and negative coping strategies (r = 0.315). The sample's mean age, the percentage of women sampled, and the research quality of the studies significantly moderated certain associations. LIMITATIONS: Large heterogeneity, the inexplicability of causal relationships between the factors and geriatric depression, and the lack of generalisability to special groups limit our findings. CONCLUSIONS: Self-esteem and perceptions of age are potential targets for improving interventions for geriatric depression in mainland China, which should continue to be developed and assessed for their effectiveness.

Multifunctional Laser-Induced Graphene Papers with Combined Defocusing and Grafting Processes for Patternable and Continuously Tunable Wettability from Superlyophilicity to Superlyophobicity.

Functional surfaces with tunable and patternable wettability have attracted significant research interests because of remarkable advantages in biomedicine, environmental, and energy storage applications. Based on combined defocusing and grafting strategy for processing laser-induced graphene papers (LIGPs) with variable surface roughness (58.18-6.08 µm) and F content (0-25.9%), their wettability can be tuned continuously from superlyophilicity (contact angle CA ≈ 0° ) to superlyophobicity (CA > 150° ), for various liquids with a wide range of surface tensions from 27.5 to 72.8 mN m-1 . In addition to reaching multiple wetting characteristics including amphiphilic, amphiphobic, and hydrophobic-oleophilic states, three designable processes are further developed for achieving LIGPs with various wetting patterns, including hydrophilic arrays or channels, hydrophobic-to-hydrophilic gradients, and Janus. Activated by the customly designed structures and properties, multifunctional and multi-scenario applications are successfully attempted, including 2D-/3D- directional cell cultivation, water transportation diode, self-triggered liquid transfer & collection, etc.

Comparative evaluation of the clinical safety and efficiency of supraclavicular and infraclavicular approaches for subclavian venous catheterization in adults: A meta-analysis.

BACKGROUND: In this meta-analysis, we investigated the success rate of subclavian venous catheterization (SVC) as well as the incidence of related complications when performed via the supraclavicular (SC) or traditional infraclavicular (IC) approaches. METHODS: Ignoring the original language, we identified and analyzed eight randomized controlled trials (RCTs) published on or before December 30, 2018, after searching the following five bibliographic databases: PubMed, Springer, Medline, EMBASE, and the Cochrane Library. All included studies compared the clinical safety and efficiency of the SC and IC approaches for SVC in adults. The Cochrane Collaboration's Risk of Bias Tool was used to evaluate the methodological quality of each RCT. Cannulation failure rates and the incidence of malposition were regarded as the primary outcome measures. Secondary outcome measures included cannulation access time and the incidence of pneumothorax and artery puncture. RESULTS: Failure rates were significantly lower for SVC via the SC approach than via the IC approach [odds ratio, 0.66; 95% confidence interval (CI), 0.47 to 0.93]. The SC approach was also associated with a decreased incidence of catheter malposition, relative to that observed for the IC approach [odds ratio, 0.24; 95% CI, 0.13 to 0.46]. The SC approach did not reduce the time required for cannulation [mean difference, -74.74; 95% CI, -157.80 to 8.33], and there were no differences in the incidence of artery puncture [odds ratio, 0.60; 95% CI, 0.29 to 1.23] or pneumothorax [odds ratio, 0.89; 95% CI, 0.33 to 2.40]. CONCLUSION: Our findings suggest that SVC via the SC approach should be utilized in adults.

Culturally adapted and lay-delivered cognitive behaviour therapy for older adults with depressive symptoms in rural China: a pilot trial.

BACKGROUND: Late-life depression issues in developing countries are challenging because of understaffing in mental health. Cognitive behavioural therapy (CBT) is effective for treating depression. AIM: This pilot trial examined the adherence and effectiveness of an eight-session adapted CBT delivered by trained lay health workers for older adults with depressive symptoms living in rural areas of China, compared with the usual care. METHOD: Fifty with screen-positive depression were randomly assigned to the CBT arm or the care as usual (CAU) arm. The primary outcomes were the session completion of older adults and changes in depressive symptoms, assessed using the Geriatric Depression Scale (GDS). RESULTS: The majority (19/24) of participants in the CBT arm completed all sessions. Mixed-effect linear regression showed that the CBT reduced more GDS scores over time compared with CAU. CONCLUSION: Lay-delivered culturally adapted CBT is potentially effective for screen-positive late-life depression.

A consideration of hoarding disorder symptoms in China.

BACKGROUND: Hoarding disorder is rarely examined in populations of non-European and/or non-Euro-American descent, especially in East Asian nations like China. Across two studies, the current investigation sets out to examine the psychometric properties of a Chinese version of a widely used measure of hoarding symptoms-the Savings Inventory Revised (SIR)-and to explore the nature of hoarding beliefs compared to a separate US sample. PROCEDURES: For the first study, 1828 college students in China completed a Mandarin translation of the SIR and measures of anxiety, depression, and obsessive-compulsive disorder. For the second study, 303 students from China and 87 students from the US completed the SIR and a novel hoarding beliefs questionnaire. FINDINGS: In the first study, the Chinese-version of the SIR demonstrated convergent and discriminant validity, as well as internal reliability and preliminary construct validity. However, evidence of temporal stability was modest and requires further investigation. In the second study, the Chinese sample endorsed greater hoarding symptoms and hoarding beliefs compared to the US sample, although only themes of usefulness and wastefulness were associated with hoarding in the Chinese samples, whereas a wider range of beliefs was linked with hoarding in the US sample. In addition, the factor structure of the SIR from the first study did not replicate in second study, suggesting that construct validity of the Chinese SIR may require further corroboration. CONCLUSIONS: The current study established preliminary evidence for the reliability and validity of the Chinese SIR, although future research is needed to confirm its temporal stability and factor structure. Hoarding beliefs in China may be centered on themes of usefulness and wastefulness compared to more heterogeneous themes in the West, suggesting differential manifestations of hoarding tendencies in cultures of non-European and/or non-Euro-American descent.

Fabrication of heterocellular spheroids with controllable core-shell structure using inertial focusing effect for scaffold-free 3D cell culture models.

Three-dimensional (3D) cell culture models capable of emulating the biological functions of natural tissues are pivotal in tissue engineering and regenerative medicine. Despite progress, the fabrication ofin vitroheterocellular models that mimic the intricate structures of natural tissues remains a significant challenge. In this study, we introduce a novel, scaffold-free approach leveraging the inertial focusing effect in rotating hanging droplets for the reliable production of heterocellular spheroids with controllable core-shell structures. Our method offers precise control over the core-shell spheroid's size and geometry by adjusting the cell suspension density and droplet morphology. We successfully applied this technique to create hair follicle organoids, integrating dermal papilla cells within the core and epidermal cells in the shell, thereby achieving markedly enhanced hair inducibility compared to mixed-structure models. Furthermore, we have developed melanoma tumor spheroids that accurately mimic the dynamic interactions between tumor and stromal cells, showing increased invasion capabilities and altered expressions of cellular adhesion molecules and proteolytic enzymes. These findings underscore the critical role of cellular spatial organization in replicating tissue functionalityin vitro. Our method represents a significant advancement towards generating heterocellular spheroids with well-defined architectures, offering broad implications for biological research and applications in tissue engineering.

The effects of psychosocial interventions on geriatric depression in the mainland of China: A systematic review and meta-analysis.

BACKGROUND: The effectiveness of psychosocial interventions for geriatric depression across different treatment settings, regions, and comorbidities in China remains unclear. Therefore, we systematically reviewed studies geared towards reducing geriatric depression in China. METHODS: Nine databases in Chinese or English from database were searched from inception through June 2024. Randomized controlled trials investigating psychosocial interventions on older adults with depression in China were included. The primary outcome was post-intervention depression measured by self-report instruments. Random-effect model was used to pool the overall effect size Hedge's g. RESULTS: In 99 studies with a total of 9369 older adults with depression, psychosocial interventions were effective compared with control conditions (Hedges' g: -1·48 [95 % CI: -1·83 to -1·13]). Comorbidity with physical disease significantly affect the pooled effect size (without comorbidity: Hedges' g = -1.19, 95 % CI: -1.42 to -0.95; with comorbidity: Hedges' g = -2.06, 95 % CI: -2.97 to -1.14; p = 0.062), and heterogeneity was substantial (without comorbidity, I2 = 91·3 %, 95 % CI: 89·5 % to 92·7 %; with comorbidity, I2 = 94·3 %, 95 % CI: 93·1 % to 95·4 %). The quality of evidence according to the GRADE criteria was generally moderate. LIMITATIONS: Significant heterogeneity among the studies reviewed was unavoidable, and the possible publication bias could lead to overestimation of the result. CONCLUSION: Psychosocial interventions are significantly effective for treating geriatric depression in China regardless of the setting, region, or therapeutic orientation. Policies should support the development and implementation of psychosocial interventions in China, especially in community settings, to reduce disease burden.

Visualizing Large-Scale Spatial Time Series with GeoChron.

In geo-related fields such as urban informatics, atmospheric science, and geography, large-scale spatial time (ST) series (i.e., geo-referred time series) are collected for monitoring and understanding important spatiotemporal phenomena. ST series visualization is an effective means of understanding the data and reviewing spatiotemporal phenomena, which is a prerequisite for in-depth data analysis. However, visualizing these series is challenging due to their large scales, inherent dynamics, and spatiotemporal nature. In this study, we introduce the notion of patterns of evolution in ST series. Each evolution pattern is characterized by 1) a set of ST series that are close in space and 2) a time period when the trends of these ST series are correlated. We then leverage Storyline techniques by considering an analogy between evolution patterns and sessions, and finally design a novel visualization called GeoChron, which is capable of visualizing large-scale ST series in an evolution pattern-aware and narrative-preserving manner. GeoChron includes a mining framework to extract evolution patterns and two-level visualizations to enhance its visual scalability. We evaluate GeoChron with two case studies, an informal user study, an ablation study, parameter analysis, and running time analysis.

Blowing Seeds across Gardens: Visualizing Implicit Propagation of Cross-Platform Social Media Posts.

Propagation analysis refers to studying how information spreads on social media, a pivotal endeavor for understanding social sentiment and public opinions. Numerous studies contribute to visualizing information spread, but few have considered the implicit and complex diffusion patterns among multiple platforms. To bridge the gap, we summarize cross-platform diffusion patterns with experts and identify significant factors that dissect the mechanisms of cross-platform information spread. Based on that, we propose an information diffusion model that estimates the likelihood of a topic/post spreading among different social media platforms. Moreover, we propose a novel visual metaphor that encapsulates cross-platform propagation in a manner analogous to the spread of seeds across gardens. Specifically, we visualize platforms, posts, implicit cross-platform routes, and salient instances as elements of a virtual ecosystem - gardens, flowers, winds, and seeds, respectively. We further develop a visual analytic system, namely BloomWind, that enables users to quickly identify the cross-platform diffusion patterns and investigate the relevant social media posts. Ultimately, we demonstrate the usage of BloomWind through two case studies and validate its effectiveness using expert interviews.

Clinical factors and outcomes of spleen-conserving surgery versus total splenectomy in splenic injuries: A nationwide database study.

BACKGROUND: The objective of this study was to identify factors associated with the use of spleen-conserving surgeries, as well as patient outcomes, on a national scale. METHODS: This retrospective cohort study (2010-2015) included patients (age≥16 years) with splenic injury in the National Trauma Data Bank. Patients who received a total splenectomy or a spleen-conserving surgery were compared for demographics and clinical outcomes. RESULTS: During the study period, 18,425 received a total splenectomy and 1,825 received a spleen-conserving surgery. Total splenectomy was more likely to be performed for patients with age>65 (odds ratio [OR]: 0.63, p â€‹< â€‹0.001), systolic blood pressure<90 (OR: 0.63, p â€‹< â€‹0.001), heart rate>120 (OR: 0.83, p â€‹= â€‹0.007), and high-grade injuries (OR: 0.18, p â€‹< â€‹0.001). Penetrating trauma patients were more likely to undergo a spleen-conserving surgery (OR: 3.31, p â€‹< â€‹0.001). The use of spleen-conserving surgery was associated with a lower risk of pneumonia (OR: 0.79, p â€‹= â€‹0.009) and venous thromboembolism (OR: 0.72, p â€‹= â€‹0.006). CONCLUSIONS: Spleen-conserving surgeries may be considered for patients with penetrating trauma, age<65, hemodynamic stability, and low-grade injuries. Spleen-conserving surgeries have decreased risk of pneumonia and venous thromboembolism.